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4-Amino-3-fluorobenzoic acid

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Identification
Molecular formula
C7H6FNO2
CAS number
455-87-8
IUPAC name
4-amino-3-fluoro-benzoic acid
State
State

At room temperature, 4-Amino-3-fluorobenzoic acid is a solid compound.

Melting point (Celsius)
219.00
Melting point (Kelvin)
492.15
Boiling point (Celsius)
484.10
Boiling point (Kelvin)
757.25
General information
Molecular weight
155.13g/mol
Molar mass
155.1350g/mol
Density
1.5450g/cm3
Appearence

4-Amino-3-fluorobenzoic acid typically appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 4-amino-3-fluoro-benzoic acid

4-amino-3-fluoro-benzoic acid, with the chemical formula C7H6FNO2, exhibits interesting solubility characteristics that can be attributed to its functional groups and molecular structure. Here are a few key points to consider:

  • Polar Characteristics: The presence of both amino (-NH2) and carboxylic acid (-COOH) groups contributes to the compound's polarity, enhancing its solubility in polar solvents like water.
  • Hydrogen Bonding: The ability of the amino and carboxyl groups to participate in hydrogen bonding facilitates solubility, particularly in aqueous environments.
  • Temperature Dependency: As with many organic acids, solubility may increase with temperature, allowing for better dissolution in warm water compared to cold water.
  • Limitations: While soluble in water, the solubility may be less favorable in non-polar solvents due to the hydrophilic nature of the functional groups.

In summary, 4-amino-3-fluoro-benzoic acid is more soluble in water than in organic solvents, driven by its polar functional groups and capacity for hydrogen bonding. As such, it could be described as a compound with good water solubility, making it a candidate for various applications in chemical synthesis and pharmaceutical formulations.

Interesting facts

Interesting Facts about 4-amino-3-fluoro-benzoic acid

4-amino-3-fluoro-benzoic acid, often abbreviated as AFBA, is a fascinating chemical compound that finds its application in various fields ranging from pharmaceuticals to materials science. Here are some engaging insights:

Key Characteristics

  • Aromatic compound: AFBA belongs to the class of aromatic compounds, which are known for their stability and unique chemical properties due to the delocalization of electrons.
  • Functional groups: It features both an amino group (–NH2) and a carboxylic acid group (–COOH), making it an essential intermediate in the synthesis of other complex molecules.
  • Fluoro substitution: The presence of the fluorine atom is significant as it can enhance the biological activity of the compound, making it a key player in drug design and development.

Applications

  • Pharmaceutical industry: AFBA is used as a building block in the synthesis of various pharmaceuticals, potentially aiding in the treatment of diseases.
  • Research: It serves as a valuable reagent in organic synthesis, particularly in the development of novel compounds.
  • Analytical chemistry: AFBA's unique properties allow it to be utilized in analytical techniques, helping scientists identify and quantify substances in complex mixtures.

Quote

As famously stated by chemist Linus Pauling, “The best way to have a good idea is to have lots of ideas.” The study of compounds like 4-amino-3-fluoro-benzoic acid exemplifies this quote, as it opens up numerous avenues for innovative research and applications.

In summary, 4-amino-3-fluoro-benzoic acid is not just a simple benzene derivative; it is a compound rich in potential and significance in various scientific realms. Its unique structure and properties make it a vital subject of study for chemists and researchers alike.

Synonyms
4-Amino-3-fluorobenzoic acid
455-87-8
BENZOIC ACID, 4-AMINO-3-FLUORO-
MFCD01660374
EINECS 207-250-1
NSC 25758
4-amino-3-fluorobenzenecarboxylic acid
BRN 2717314
3-fluoro-4-aminobenzoic acid
DTXSID70196540
3-14-00-01153 (Beilstein Handbook Reference)
4-Amino-3-fluoro-benzoic acid
4-AMINO-3-FLUOROBENZOICACID
NSC25758
WLN: ZR BF DVQ
SCHEMBL97816
CHEMBL3278369
DTXCID10119031
BBL103405
CL8101
NSC-25758
STL557215
AKOS005070217
AC-3884
CS-W008331
FA17524
SB76030
SY007349
DB-024080
4-Amino-3-fluoro-benzoic acid;NSC 25758
A2165
NS00043530
EN300-52713
3T-0232
Z756936498
207-250-1