Lidocaine | Solubility of Things

Identification

Molecular formula

C₁₄H₂₂ClN₃O₂

CAS number

137-58-6

IUPAC name

4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide

State

Lidocaine is typically in a solid state at room temperature. It is often available in the form of gels, creams, or injectable solutions, depending on its clinical application.

Melting point (Celsius)

66.00

Melting point (Kelvin)

339.15

Boiling point (Celsius)

350.00

Boiling point (Kelvin)

623.15

General information

Molecular weight

234.34g/mol

Molar mass

234.3370g/mol

Density

1.0260g/cm³

Appearence

Lidocaine is typically available as a white crystalline powder. It can also appear as a colorless solid depending on its form. The compound is often used in its hydrochloride salt form, which is also a white crystalline substance.

Comment on solubility

Solubility of 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide

The compound 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide (C₁₄H₂₂ClN₃O₂) displays interesting solubility characteristics, largely influenced by its chemical structure.

Polarity Factors: The presence of polar functional groups, such as the amino and methoxy groups, contributes to its solubility in polar solvents like water.
Hydrophobic Sections: The diethylamino group adds a hydrophobic character, which may reduce solubility in highly polar solvents.
Solvent Interaction: Its solubility may be enhanced in mixed solvents or organic solvents that can stabilize both polar and non-polar interactions.

Overall, one can expect that this compound might exhibit moderate solubility in water and enhanced solubility in organic solvents due to its dual nature. As noted, “solubility often depends on the balance between hydrophilic and hydrophobic characteristics.”

For practical applications and experiments, testing its solubility in various solvent systems would provide a clearer picture of its behavior in different mediums, ensuring effective handling and usage.

Interesting facts

Interesting Facts about 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide

This compound, commonly referred to in chemical circles by its IUPAC name, is noteworthy for several reasons. As a derivative of benzamide, it carries significant implications in medicinal chemistry. Here are some intriguing points about this compound:

Pharmacological Potential: This compound exhibits properties that could be relevant in drug design, particularly in the context of therapeutic agents targeting various biological pathways.
Structure-Activity Relationship (SAR): The presence of the diethylamino group and other substituents can influence the compound's interaction with biological targets, making it an interesting subject for SAR studies.
Chlorine Atom Influence: The inclusion of the chlorine atom could affect both the lipophilicity and overall reactivity of the compound, providing valuable insights into chemical behavior in physiological conditions.
Synthesis Routes: From a synthetic standpoint, the methods to create this compound can vary. Understanding these pathways not only sheds light on its synthesis but also enhances our knowledge of reaction mechanisms in organic chemistry.
Research Applications: Researchers may explore the use of this compound in developing new therapies or understanding its role as a molecular probe in various biological assays.

As you delve deeper into this compound, remember that chemically modifying it could lead to even more potent derivatives. The diversity of possible modifications showcases the beauty and complexity of chemical synthesis and medicinal chemistry!

Synonyms

metoclopramide

364-62-5

Methochlopramide

Metochlopramide

Metaclopramide

Reliveran

Primperan

Reglan

Metaclopromide

Elieten

Metoclopramida

Metoclol

Moriperan

Terperan

Plasil

4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide

Metoclopramidum

2-Methoxy-5-chloroprocainamide

Maxolon

Plasil (pharmaceutical)

4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide

Methoclopramide

Metoclopramidum [INN-Latin]

Metoclopramida [INN-Spanish]

5-Chloro-2-methoxyprocainamide

Clopra

Megaldrate

Methoxyclopramide

DEL 1267

Gimoli

4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-o-anisamide

4-Amino-5-chloro-2-methoxy-N-(beta-diethylaminoethyl)benzamide

Benzamide, 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-

EINECS 206-662-9

UNII-L4YEB44I46

N-(Diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide

BRN 1884366

L4YEB44I46

DTXSID6045169

Benzamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxy-

HSDB 7841

CHEBI:107736

CLOPRA-"YELLOW"

2-Methoxy-4-amino-5-chloro-N,N-dimethylaminoethyl)benzamide

DTXCID4025169

2-methoxy-4-amino-5-chloro-N,N-(dimethylaminoethyl)benzamide

Gimoti (metoclopramide nasal spray)

NCGC00015643-07

o-Anisamide, 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-

Metoclopramidum (INN-Latin)

Metoclopramida (INN-Spanish)

METOCLOPRAMIDE (MART.)

METOCLOPRAMIDE [MART.]

o-Anisamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-

Metoclopramide [INN:BAN:JAN]

METOCLOPRAMIDE (EP MONOGRAPH)

METOCLOPRAMIDE [EP MONOGRAPH]

Terperan (TN)

CAS-364-62-5

Elieten (TN)

Regla

Metochloropramide

Metoclopramide; 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide

Metoclopramide Base

MFCD00211338

Reglan (Salt/Mix)

Maxolon (Salt/Mix)

Paspertin (Salt/Mix)

Spectrum_001638

4-amino-5-chloro-N-(2-diethylaminoethyl)-2-methoxybenzamide

CHEMBL86

Prestwick0_000209

Prestwick1_000209

Prestwick2_000209

Prestwick3_000209

Spectrum2_001720

Spectrum3_000504

Spectrum4_000964

Spectrum5_001449

Lopac-M-0763

Biomol-NT_000082

bmse000779

METOCLOPRAMIDE [MI]

METOCLOPRAMIDE [INN]

METOCLOPRAMIDE [JAN]

Lopac0_000762

SCHEMBL18629

BSPBio_000197

BSPBio_002027

GTPL241

KBioGR_001307

KBioSS_002118

Metoclopramide (JP18/INN)

METOCLOPRAMIDE [HSDB]

cid_23659

DivK1c_000069

METOCLOPRAMIDE [VANDF]

SPBio_001740

SPBio_002118

US9132134, Metoclopramide

BPBio1_000217

BPBio1_001100

METOCLOPRAMIDE [WHO-DD]

Primperan (tablet) (Salt/Mix)

BDBM48320

KBio1_000069

KBio2_002118

KBio2_004686

KBio2_007254

KBio3_001527

A03FA01

Benzamide, 4-amino-5-chloro-N-

NINDS_000069

HMS2089G16

HMS3886P05

4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide

BCP30761

Tox21_110188

4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide (Mcp)

s5862

STL257058

(metaclopramide)4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide

(metoclopramide)4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide

4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide(Metoclopramide)

AKOS000280832

Tox21_110188_1

CCG-204847

CS-1064

DB01233

FM01545

KS-5055

SDCCGSBI-0050740.P005

4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide (metoclopramide)

IDI1_000069

NCGC00015643-01

NCGC00015643-02

NCGC00015643-03

NCGC00015643-04

NCGC00015643-05

NCGC00015643-06

NCGC00015643-08

NCGC00015643-09

NCGC00015643-11

NCGC00015643-13

NCGC00015643-18

NCGC00024440-03

NCGC00024440-04

AC-37197

DA-75515

HY-17382

NCI60_003185

CAS-7232-21-5

SBI-0050740.P004

AB00053498

M2218

NS00000392

C07868

D00726

EN300-119507

H11996

AB00053498-13

AB00053498_14

L001078

Metoclopramide, VETRANAL(TM), analytical standard

Q421095

BRD-K75641298-001-01-5

BRD-K75641298-003-05-2

BRD-K75641298-003-16-9

BRD-K75641298-003-25-0

Z2196779550

2-Methoxy-4-amino-5-chloro-N,N-dimethylaminoethylbenzamide

Metoclopramide, European Pharmacopoeia (EP) Reference Standard

N-(2-diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide

4-Amino-5-chloro-2-methoxy-N-(.beta.-diethylaminoethyl)benzamide

4-amino-5-chloro-N-[2-(diethylamino)-ethyl]-2-methoxybenzamide

4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide;hydrochloride

4-azanyl-5-chloranyl-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide;hydrochloride

206-662-9