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Lidocaine hydrochloride

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Identification
Molecular formula
C14H22ClN3O2.2HCl
CAS number
73-78-9
IUPAC name
4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide;dihydrochloride
State
State

At room temperature, lidocaine hydrochloride exists in a solid state. It is commonly found and administered in solution form in medical settings for intravenous or topical applications.

Melting point (Celsius)
80.00
Melting point (Kelvin)
353.15
Boiling point (Celsius)
275.00
Boiling point (Kelvin)
548.15
General information
Molecular weight
288.81g/mol
Molar mass
270.7980g/mol
Density
1.0500g/cm3
Appearence

Lidocaine hydrochloride typically appears as a white crystalline powder. It is odorless and has a slightly bitter taste. The powder is used in its anhydrous form as well as in hydrated forms, which may appear as small crystals.

Comment on solubility

Solubility of 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide; dihydrochloride

The compound 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide; dihydrochloride demonstrates notable solubility characteristics that are important for its applications. As a dihydrochloride salt, it tends to exhibit enhanced solubility in polar solvents, particularly:

  • Water: Being a salt, it usually dissolves readily in aqueous environments, which is essential for its bioavailability and pharmacological effectiveness.
  • Alcohols: Modest solubility can also be observed in alcohols, which can be useful for specific formulation purposes.

However, factors influencing the solubility of this compound include:

  • Temperature: An increase in temperature generally enhances solubility.
  • pH Levels: Because of the presence of amino and chloro groups, the pH of the solution can affect the ionization state, and consequently, the solubility.

In conclusion, 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide; dihydrochloride is primarily soluble in polar protic solvents, making it versatile for various applications, particularly in pharmaceutical contexts where solubility is critical.

Interesting facts

Interesting Facts about 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide; dihydrochloride

This intriguing compound, often recognized for its pharmaceutical relevance, plays a critical role in medicinal chemistry. With its complex structure, it showcases the fascinating interplay between functional groups which grant it unique properties. Here are some engaging points to note:

  • Pharmaceutical Applications: This compound is part of a class of drugs that exhibits potent effects on various receptors, making it a valuable subject of study for drug discovery and development.
  • Structural Significance: The presence of both the diethylamino group and the methoxy substituent contributes to its overall biological activity, enhancing its binding affinity to targeted sites.
  • Chlorine's Role: The chlorine atom in its structure not only influences the compound's physicochemical properties but also enhances its potency by improving metabolic stability.
  • Impact on Central Nervous System: Research suggests potential applications in treating conditions related to the central nervous system, highlighting its importance in neurology and psychiatry.

Furthermore, understanding the mechanism of action of this compound can unveil

  • How it interacts with biological targets
  • The possible side effects associated with its use
  • The implications of substituent variations on its pharmacological profile

In conclusion, 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide; dihydrochloride serves as a vital example of how small changes in molecular structure can lead to significant differences in a compound's application and efficacy. It is a reminder of the importance of comprehensive studies in medicinal chemistry to unveil the therapeutic potentials underlying such complex molecules.

Synonyms
Metoclopramide dihydrochloride
4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide dihydrochloride
UNII-5YNA80E9TO
5YNA80E9TO
4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide dihydrochloride
EINECS 219-926-3
DTXSID20180434
ANHYDROUS METOCLOPRAMIDE DIHYDROCHLORIDE
METOCLOPRAMIDE DIHYDROCHLORIDE [WHO-DD]
O-ANISAMIDE, 4-AMINO-5-CHLORO-N-(2-(DIETHYLAMINO)ETHYL)-, DIHYDROCHLORIDE
BENZAMIDE, 4-AMINO-5-CHLORO-N-(2-(DIETHYLAMINO)ETHYL)-2-METHOXY-, HYDROCHLORIDE (1:2)
Dihydrochloride, Metoclopramide
DTXCID30102925
2576-84-3
4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide;dihydrochloride
meto-clopramide dihydrochloride
SCHEMBL678940
HPPDSFRJRMUHSC-UHFFFAOYSA-N
AKOS025895867
NS00076208
Q27263065