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Venlafaxine

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Identification
Molecular formula
C17H27ClN2O2
CAS number
93413-69-5
IUPAC name
4-amino-5-chloro-N-[2-(ethylamino)ethyl]-2-methoxy-benzamide
State
State

At room temperature, venlafaxine is primarily found in a solid crystalline form.

Melting point (Celsius)
215.00
Melting point (Kelvin)
488.15
Boiling point (Celsius)
334.60
Boiling point (Kelvin)
607.75
General information
Molecular weight
313.87g/mol
Molar mass
313.8710g/mol
Density
1.2700g/cm3
Appearence

Venlafaxine is typically found as a white to slightly off-white crystalline solid. It is known for its high solubility in water and displays overall moderate stability.

Comment on solubility

Solubility of 4-amino-5-chloro-N-[2-(ethylamino)ethyl]-2-methoxy-benzamide

The solubility of 4-amino-5-chloro-N-[2-(ethylamino)ethyl]-2-methoxy-benzamide can be influenced by various factors, including its molecular structure and the presence of functional groups. This compound, with its complex arrangement, exhibits certain characteristics that impact its solubility profile:

  • Polarity: The presence of the amine and chloro groups can introduce polar characteristics, potentially enhancing solubility in polar solvents such as water.
  • Hydrogen Bonding: The amino group can engage in hydrogen bonding, which may aid in solubility in protic solvents.
  • Solvent Compatibility: It is generally more soluble in organic solvents like ethanol and methanol than in non-polar solvents due to its polar functional groups.
  • pH Influence: The ionic nature of the amino group means that changes in pH can significantly affect solubility, increasing solubility in more acidic solutions.

As a rule of thumb, compounds with both hydrophobic and hydrophilic domains can exhibit solubility in mixed solvent systems. Thus, while this compound may have moderate solubility in pure water, its overall solubility greatly depends on the choice of solvent and environmental conditions. To quote a common principle in chemistry, "like dissolves like," indicating that the solubility characteristics of 4-amino-5-chloro-N-[2-(ethylamino)ethyl]-2-methoxy-benzamide are best understood in the context of its interactions with both polar and non-polar solvents.

Interesting facts

Interesting Facts about 4-amino-5-chloro-N-[2-(ethylamino)ethyl]-2-methoxy-benzamide

This compound, often referred to in research as an important derivative of benzamide, holds significant potential in various fields of medicinal chemistry and pharmacology. Here are some fascinating insights about this specific compound:

  • Pharmaceutical Relevance: This compound features a unique combination of functional groups that may enhance its biological activity. The presence of the amino and chloro groups contributes to its interaction with various biological targets, making it a candidate for drug development.
  • Structural Diversity: The integration of an ethylamino side chain adds to the structural complexity, allowing for a variety of possible conformations. Such diversity is crucial for optimizing interactions with target proteins or enzymes.
  • Mechanism of Action: Compounds like this one can exhibit a range of pharmacological effects, potentially acting as enzyme inhibitors or receptor modulators. Understanding its mechanism of action could lead to breakthroughs in treating conditions like cancer or neurodegenerative diseases.
  • Synthesis and Modifications: The synthetic path to this compound showcases the ingenuity of organic synthesis techniques. Chemists often explore different synthetic routes to modify the molecule for improved efficacy or reduced side effects.
  • Research Potential: As scientists continue to investigate the properties of this compound, it serves as a foundation for developing more potent analogs. Ongoing research may uncover novel therapeutic applications that address unmet medical needs.
  • Bioactivity Studies: Investigating the bioactivity of this compound can provide insights into its pharmacokinetics and pharmacodynamics, vital for assessing its potential safety and effectiveness in clinical settings.

In conclusion, 4-amino-5-chloro-N-[2-(ethylamino)ethyl]-2-methoxy-benzamide exemplifies the blend of chemistry and biology, showcasing how structural modifications can lead to significant advancements in medicine. As researchers continue to explore this compound, its potential impact on health and disease remains promising.

Synonyms
27260-19-1
Desethylmetoclopramide
44O5BC8E9J
4-Amino-5-chloro-N-(2-(ethylamino)ethyl)-o-anisamide
Benzamide, 4-amino-5-chloro-N-(2-(ethylamino)ethyl)-2-methoxy-
DTXSID50181712
4-Amino-5-chloro-N-[2-(ethylamino)ethyl]-o-anisamide
RefChem:1083178
DTXCID90104203
N-Desethyl Metoclopramide
4-amino-5-chloro-N-[2-(ethylamino)ethyl]-2-methoxybenzamide
Monoethyl metoclopramide
4-Amino-5-chloro-N-(2-(ethylamino)ethyl)-2-methoxybenzamide
Deetilmetoclopramide
Deetilmetoclopramide [Italian]
Deetilato metoclopramide
Deetilato metoclopramide [Italian]
BRN 2850460
MDMCP
4-Amino-5-chloro-N-(2-ethylaminoethyl)-2-methoxybenzamide
starbld0038633
4-Amino-5-chloro-N-(2-etilaminoetil)-2-metossibenzamide [Italian]
Metoclopramide N-Desethyl
o-ANISAMIDE, 4-AMINO-5-CHLORO-N-(2-(ETHYLAMINO)ETHYL)-
CHEMBL616
UNII-44O5BC8E9J
N-(Ethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide
SCHEMBL15585981
4-Amino-5-chloro-N-(2-etilaminoetil)-2-metossibenzamide
EX-A3519
METOCLOPRAMIDE METABOLITE M3
AKOS027192237
NS00115929
H42394
4-Amino-5-chloro-N-[2-(ethylamino)ethyl]-2-methoxybenzamide; 4-Amino-5-chloro-N-[2-(ethylamino)ethyl]-o-anisamide; N-(Ethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide