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Puromycin

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Identification
Molecular formula
C22H29N7O5
CAS number
58-58-2
IUPAC name
4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrrolo[2,3-d]pyrimidine-5-carboxamide
State
State

Puromycin is typically in a solid state at room temperature, presenting itself most commonly as a crystalline powder.

Melting point (Celsius)
218.00
Melting point (Kelvin)
491.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
273.15
General information
Molecular weight
471.52g/mol
Molar mass
471.4780g/mol
Density
1.5300g/cm3
Appearence

Puromycin appears as a white to off-white crystalline powder. The compound is a derivative of the antibiotic puromycin which inhibits protein synthesis.

Comment on solubility

Solubility of 4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrrolo[2,3-d]pyrimidine-5-carboxamide

The solubility of 4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrrolo[2,3-d]pyrimidine-5-carboxamide can be characterized by several factors:

  • Polarity: Due to its multiple hydroxyl groups and nitrogen atoms, this compound is likely to exhibit significant polar characteristics, which generally enhances its solubility in polar solvents such as water.
  • Functional Groups: The presence of functional groups such as amino and hydroxyl moieties often results in hydrogen bonding. This interaction typically increases solubility in aqueous environments.
  • Structural Considerations: The complex structure of the molecule, particularly its heterocyclic components, may influence the degree of intermolecular interactions, affecting solubility.
  • pH Dependency: As with many carboxamides, the solubility of this compound may be pH-dependent, reflecting how its ionization status changes in different pH environments.

In summary, while specific empirical data will provide the most accurate understanding, the combination of its polar functional groups, potential for hydrogen bonding, and pH sensitivity suggests that this compound may exhibit notable solubility in polar solvents.

Interesting facts

Interesting Facts about 4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrrolo[2,3-d]pyrimidine-5-carboxamide

This compound, a complex molecule belonging to the family of pyrrolo-pyrimidines, has garnered significant interest in the field of medicinal chemistry due to its intriguing structure and potential therapeutic applications. Below are some fascinating insights about this compound:

  • Unique Structure: The compound features multiple chiral centers, which contribute to its diverse biological activities. Its stereochemistry is essential for the binding and interaction with biological targets.
  • Biological Relevance: Compounds like this play a crucial role in the development of antiviral and anticancer therapies, as they can inhibit key enzymes involved in disease progression.
  • Chemical Versatility: The presence of amino and hydroxyl functional groups allows for potential modifications, presenting opportunities for researchers to tailor its properties for specific uses.
  • Research Versatility: This compound may serve as a valuable tool for studying enzyme mechanisms and cell signaling pathways, enhancing our understanding of complex biological systems.
  • Potential Drug Leads: The intricate structure and potential pharmacological effects make it a good candidate for drug discovery, with ongoing research likely to unveil new therapeutic avenues.

As the field of chemistry progresses, compounds like 4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrrolo[2,3-d]pyrimidine-5-carboxamide may lead to breakthrough advancements in targeted therapies, emphasizing the importance of structural nuances in medicinal chemistry.

Synonyms
sangivamycin
18417-89-5
7-Deazaadenosine-7-carboxamide
Antibiotic B-14437
NSC-65346
L8YQ8Z3T9T
7-Deaza-7-carbamoyladenosine
BRN 0626355
4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carboxamide
CHEBI:85997
B-14437
UNII-L8YQ8Z3T9T
SKI 27013
4-Amino-7-beta-D-ribofuranosyl-7H-pyrrolo(2,3-d)pyrimidine-5-carboxamide
4-amino-7-beta-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide
BA-90912
4-amino-5-carboxamido-7-(D-ribofuranosyl)-pyrrolo-(2,3-d)pyrimidine
NSC 65346
B 90912
7H-Pyrrolo(2,3-d)pyrimidine-5-carboxamide, 4-amino-7-beta-D-ribofuranosyl-
4-Amino-7-.beta.-D-ribofuranosyl-7H-pyrrolo(2,3-d)pyrimidine-5-carboxamide
7H-Pyrrolo(2,3-d)pyrimidine-5-carboxamide, 4-amino-7-.beta.-D-ribofuranosyl-
7H-Pyrrolo[2,3-d]pyrimidine-5-carboxamide, 4-amino-7-.beta.-D-ribofuranosyl-
4-amino-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)pyrrolo(2,3-d)pyrimidine-5-carboxamide
obzjzdhrxbkktj-uhfffaoysa-n
CHEMBL101892
4-amino-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide
Sanzivamycin
Sangivamycin, hydrochloride
3nyn
SGV
cid_5153
BIDD:GT0419
SCHEMBL195540
OBZJZDHRXBKKTJ-JTFADIMSSA-N
DTXSID601028118
GLXC-05069
BDBM50049820
AKOS040759898
AS181128
MS-24486
HY-118384
CS-0065802
NS00011704
Q27158840
4-Amino-5-carboxamide-7-(D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine
4-amino-7-(beta-d-ribofuranosyl)-7h-pyrrolo[2,3-d]pyrimidine-5-carboxamide
4-amino-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide
4-Amino-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid amide
4-Amino-7-(3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid amide
4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrrolo[2,3-d]pyrimidine-5-carboxamide