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Sulfadiazine

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Identification
Molecular formula
C10H10N4O2S
CAS number
68-35-9
IUPAC name
4-amino-N-(1-ethyl-2-oxo-pyrimidin-4-yl)benzenesulfonamide
State
State

At room temperature, Sulfadiazine is in a solid state, specifically as a crystalline powder. It is stable and non-volatile in its solid form.

Melting point (Celsius)
253.00
Melting point (Kelvin)
526.15
Boiling point (Celsius)
722.50
Boiling point (Kelvin)
995.65
General information
Molecular weight
250.28g/mol
Molar mass
250.2820g/mol
Density
1.4900g/cm3
Appearence

Sulfadiazine is typically found as a white or slightly yellowish crystalline powder. It is often odorless and has a slightly bitter taste. The compound tends to form crystals which reflect light in a distinctly characteristic way.

Comment on solubility

Solubility of 4-amino-N-(1-ethyl-2-oxo-pyrimidin-4-yl)benzenesulfonamide

The solubility of the compound 4-amino-N-(1-ethyl-2-oxo-pyrimidin-4-yl)benzenesulfonamide (C10H10N4O2S) can be influenced by several factors. Exploring its solubility provides valuable insights into its chemical behavior and potential applications.

Factors Affecting Solubility

  • Polarity: Solubility is often affected by the polarity of the compound. Compounds with polar functional groups are generally more soluble in polar solvents.
  • Hydrogen Bonding: The presence of amino and sulfonamide groups suggests the potential for hydrogen bonding, which can enhance solubility in water.
  • Molecular Weight: Higher molecular weight may decrease solubility; however, this is counterbalanced by the presence of solubilizing functional groups.
  • pH Levels: The solubility may vary with pH, especially for compounds that can ionize.

In general, this compound is expected to exhibit some degree of solubility in polar solvents such as water and ethanol, primarily due to its polar functional groups. As such, one might say that:

"The solubility of a compound mirrors its ability to interact with solvent molecules, shaping its path in both laboratory and biological settings."

Nonetheless, the precise solubility can be determined experimentally, providing critical data for researchers working with this compound. Understanding these solubility characteristics can guide its use in pharmaceuticals, agrochemicals, and other applications where solubility plays a crucial role.

Interesting facts

Interesting Facts about 4-amino-N-(1-ethyl-2-oxo-pyrimidin-4-yl)benzenesulfonamide

This compound, known as 4-amino-N-(1-ethyl-2-oxo-pyrimidin-4-yl)benzenesulfonamide, is a notable member of the sulfonamide family, which are synthetic antibiotics. The following points highlight its significance in scientific research:

  • Pharmaceutical Applications: Sulfonamides have a rich history as antibacterial agents, and derivatives like this one are studied for their potential use in treating various infections.
  • Structure-Activity Relationship: The combination of the pyrimidine ring and the sulfonamide group in its structure demonstrates unique interactions within biological systems, making it a subject of interest for medicinal chemists.
  • Research and Development: Compounds like this are often tested for their efficacy against resistant bacterial strains, contributing valuable data on drug design and efficacy.
  • Diverse Functionalities: The amino and ketone functional groups present in the molecule enhance its reactivity, allowing chemists to explore numerous synthetic pathways for modification and optimization.

Furthermore, the use of 4-amino-N-(1-ethyl-2-oxo-pyrimidin-4-yl)benzenesulfonamide in research allows scientists to delve into:

  1. The relationship between molecular structure and biological activity.
  2. Innovative strategies to overcome microbial resistance.
  3. Combining this compound with other therapeutic agents for synergistic effects.

With ongoing research and development, 4-amino-N-(1-ethyl-2-oxo-pyrimidin-4-yl)benzenesulfonamide holds promise as a contributing factor in the future of pharmacology and infectious disease treatment.

Synonyms
sulfacytine
17784-12-2
Sulfacitine
Renoquid
1-Ethyl-N-sulfanilylcytosine
Sulfacitina
1-Ethyl N4-sulfanilylcytosin
CI-636
Sulfacitinum
Sulfacitinum [INN-Latin]
Sulfacitina [INN-Spanish]
Nl-sulfanilyl-1-ethylcytosine
N-Sulfanilyl-l-ethylcytosine
N-Sulfanilyl-1-ethylcytosine
NSC 356717
HSDB 3272
4-amino-N-(1-ethyl-2-oxopyrimidin-4-yl)benzenesulfonamide
CI 636
CL 636
NSC-356717
Sulfacitine [INN]
UNII-T795873AJP
Sulfacytine (USAN)
Renoquid; Sulfacitine
1401-49-6
DTXSID6023606
Sulfanilamide, N1-(1-ethyl-1,2-dihydro-2-oxo-4-pyrimidinyl)-
N(sup 1)-(1-Ethyl-1,2-dihydro-2-oxo-4-pyrimidinyl)sulfanilamide
T795873AJP
Benzenesulfonamide, 4-amino-N-(1-ethyl-1,2-dihydro-2-oxo-4-pyrimidinyl)-
4-amino-N-(1-ethyl-2-oxo-1,2-dihydropyrimidin-4-yl)benzenesulfonamide
Benzenesulfonamide,4-amino-N-(1-ethyl-1,2-dihydro-2-oxo-4-pyrimidinyl)-
DTXCID903606
Sulfanilamide, N(1)-(1-ethyl-1,2-dihydro-2-oxo-4-pyrimidinyl)-
NSC356717
Sulfacitinum (INN-Latin)
SULFACYTINE [USAN]
Sulfacitina (INN-Spanish)
SULFACYTINE (MART.)
SULFACYTINE [MART.]
4-amino-N-(1-ethyl-2-oxo-1,2-dihydropyrimidin-4-yl)benzene-1-sulfonamide
Renoquid (TN)
Sulfactin (antibiotic)
Sulfacytine [USAN:INN:BAN]
starbld0009659
SULFACYTINE [MI]
SULFACYTINE [HSDB]
SULFACYTINE [VANDF]
SCHEMBL49377
SULFACITINE [WHO-DD]
CHEMBL1201056
SULFACYTINE [ORANGE BOOK]
CHEBI:135230
SIBQAECNSSQUOD-UHFFFAOYSA-N
N(sup1)-(1-Ethyl-1,2-dihydro-2-oxo-4-pyrimidinyl)sulfanilamide
Tox21_113734
EX-A10299
AKOS040754107
DB01298
NCGC00253598-01
DA-09179
HY-16472
CAS-17784-12-2
CS-0006353
NS00011875
D02519
G12151
Sulfanilamide,2-dihydro-2-oxo-4-pyrimidinyl)-
EN300-18536155
Benzenesulfonamide,2-dihydro-2-oxo-4-pyrimidinyl)-
Q7636169
N1-(1-Ethyl-1,2-dihydro-2-oxo-4-pyrimidinyl)sulfanilamide
N(1)-(1-ethyl-1,2-dihydro-2-oxo-4-pyrimidinyl)sulfanilamide
4-Amino-N-(1-ethyl-2-oxo-1,2-dihydro-4-pyrimidinyl)benzenesulfonamide #