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Lidocaine

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Identification
Molecular formula
C14H22N2O
CAS number
137-58-6
IUPAC name
4-amino-N-(2,6-dimethylphenyl)benzamide
State
State

At room temperature, lidocaine is typically in a solid state as a white crystalline powder. In its pharmaceutical form, it may also be found as a liquid in solutions for injection or topical application.

Melting point (Celsius)
68.00
Melting point (Kelvin)
341.00
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.00
General information
Molecular weight
234.34g/mol
Molar mass
234.3370g/mol
Density
1.0260g/cm3
Appearence

Lidocaine is typically a white crystalline powder. It is slightly soluble in water and soluble in alcohol and chloroform, giving a characteristic appearance of purity and fineness. It is often made available in solution form for medical use, which appears as a clear liquid.

Comment on solubility

Solubility of 4-amino-N-(2,6-dimethylphenyl)benzamide

The solubility of 4-amino-N-(2,6-dimethylphenyl)benzamide, often referred to as a derivative of benzamide, can be influenced by various factors. In general, this compound exhibits limited solubility in water due to:

  • Hydrophobic Character: The presence of the dimethyl groups increases its non-polar characteristics, making it less likely to interact favorably with polar solvents like water.
  • Amine Group: Though the amine (-NH2) can engage in hydrogen bonding, its overall hydrophobic environment may hinder full solvation.

As a result, the solubility tends to be higher in organic solvents such as:

  1. DMSO (Dimethyl sulfoxide)
  2. Dimethylformamide (DMF)
  3. Acetone

It is important to note that solubility can also be affected by temperature and pH:

  • Higher temperatures typically enhance solubility.
  • Altering the pH can affect the ionization of the amine group, potentially improving solubility in specific conditions.

In summary, the solubility of 4-amino-N-(2,6-dimethylphenyl)benzamide is limited in water, but it is more favorable in non-polar solvents. Observing these properties is crucial for applications in pharmaceutical formulations and chemical synthesis.

Interesting facts

Interesting Facts about 4-amino-N-(2,6-dimethylphenyl)benzamide

4-amino-N-(2,6-dimethylphenyl)benzamide is a compound that belongs to the class of amides and is known for its intriguing chemical properties and potential applications in various fields. Here are some interesting facts about this compound:

  • Structure Variety: This compound features an amine and amide functional group, which contributes to its unique reactivity and bonding characteristics, making it a fascinating subject for chemical study.
  • Pharmaceutical Relevance: It has been explored in pharmaceutical research for its potential biological activity. Compounds with similar structures have shown promise in targeting specific therapeutic pathways.
  • Substituent Effects: The presence of the 2,6-dimethylphenyl group provides steric hindrance, which can influence the compound's reactivity and interaction in biochemical environments.
  • Research Potential: Scientists continually investigate compounds like 4-amino-N-(2,6-dimethylphenyl)benzamide for their potential roles in developing new drugs, particularly in fields such as cancer and metabolic disorders.
  • Hydrogen Bonding: The amino group can form hydrogen bonds, contributing to the compound's solubility and interaction with biological macromolecules, which is crucial for its efficacy in medicinal chemistry.

As a compound of interest, 4-amino-N-(2,6-dimethylphenyl)benzamide exemplifies the complex interplay of structural features and biological activity in the realm of organic chemistry. Its study not only enhances our understanding of amide chemistry but also holds promise for new therapeutic advancements in medicine.

Synonyms
Ameltolide
4-Amino-N-(2,6-dimethylphenyl)benzamide
787-93-9
Ameltolida
4-Amino-2',6'-benzoxylidide
Ameltolidum [INN-Latin]
Ameltolida [INN-Spanish]
Ameltolidum
LY201116
LY-201116
Ameltolide [USAN:INN:BAN]
2',6'-BENZOXYLIDIDE, 4-AMINO-
LY 201116
ADD 75073
BRN 2734562
F83240ZOVE
DTXSID7052860
Benzamide, 4-amino-N-(2,6-dimethylphenyl)-
AMELTOLIDE [INN]
AMELTOLIDE [USAN]
DTXCID4031271
Ameltolidum (INN-Latin)
Ameltolida (INN-Spanish)
Lilly 201116
804-885-1
Benzamide,4-amino-N-(2,6-dimethylphenyl)-
CHEBI:6342
LY 201116;ADD 75073
UNII-F83240ZOVE
ADD-75073
Ameltolide (USAN/INN)
CHEMBL22916
SCHEMBL635392
HZIWGOAXOBPQGY-UHFFFAOYSA-N
AAA78793
Tox21_113872
MFCD00865288
STK360030
AKOS000136947
NCGC00253759-01
BS-36184
CAS-787-93-9
4-amino-N-(2,6-dimethylphenyl) benzamide
HY-114705
4-Amino-N-(2,6-dimethyl-phenyl)-benzamide
CS-0064135
NS00122134
D02892
F87563
EN300-14405055
SR-01000944824
Q4742349
SR-01000944824-1
4-AMINO-N-(2,6-DIMETHYLPHENYL)BENZAMIDE 95%
BRD-K48173020-001-01-8
Z111686304