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Sulfamethazine

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Identification
Molecular formula
C12H14N4O2S
CAS number
57-68-1
IUPAC name
4-amino-N-(2,6-dimethylpyrimidin-4-yl)benzenesulfonamide
State
State

At room temperature, sulfamethazine is typically a solid. It exists as a powder that can be easily handled and stored in suitable containers. Its stability at room temperature makes it ideal for pharmaceutical applications.

Melting point (Celsius)
197.00
Melting point (Kelvin)
470.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
278.34g/mol
Molar mass
278.3350g/mol
Density
1.2574g/cm3
Appearence

Sulfamethazine is a white or slightly yellowish crystalline powder. It is practically odorless, with a slightly bitter taste. Given its crystalline nature, it may reflect light and appear shiny under certain lighting conditions. As a powder, it can be compacted to form aggregates or granules.

Comment on solubility

Solubility of 4-amino-N-(2,6-dimethylpyrimidin-4-yl)benzenesulfonamide

The solubility of the compound 4-amino-N-(2,6-dimethylpyrimidin-4-yl)benzenesulfonamide (C12H14N4O2S) is an intriguing aspect that can influence its applications in pharmaceutical and chemical contexts. Understanding its solubility allows for better formulation and utilization in various settings.

Factors Affecting Solubility:

  • Polarity: As a sulfonamide, this compound contains polar functional groups which can impact interactions with solvents, enhancing solubility in polar solvents.
  • Hydrogen Bonding: The amino group can engage in hydrogen bonding, potentially increasing solubility in water.
  • Structural Variation: The presence of the pyrimidine and the position of dimethyl groups contribute to the compound's overall solubility properties.

Generally, **non-polar** or **hydrophobic** solutes show *poor solubility* in aqueous environments, while **polar** compounds are more readily soluble. Thus, the interplay between these factors can lead to varying solubility profiles.

Solubility Insights:

  • The compound may exhibit moderate solubility in water.
  • It is likely more soluble in organic solvents due to its hydrophobic components.
  • Its application in medicinal chemistry suggests a need for adequate solubility in biological environments for effective absorption.

In conclusion, the solubility of 4-amino-N-(2,6-dimethylpyrimidin-4-yl)benzenesulfonamide is primarily influenced by its intrinsic molecular structure and the nature of the solvent used. This makes it a fascinating subject for further investigation in both laboratory and industrial settings.

Interesting facts

Interesting Facts about 4-amino-N-(2,6-dimethylpyrimidin-4-yl)benzenesulfonamide

The compound 4-amino-N-(2,6-dimethylpyrimidin-4-yl)benzenesulfonamide is a fascinating example of a pharmaceutical intermediary that has garnered attention in medicinal chemistry. Here are some interesting points regarding this compound:

  • Structure and Function: The compound features a sulfonamide group, which is known for its antibacterial properties. The presence of the pyrimidine ring makes it particularly significant in the development of drugs targeting various health issues.
  • Biological Activity: Compounds of this nature often exhibit a range of biological activities, including antimicrobial and antitumor potentials, making them candidates for further pharmaceutical development.
  • Research Applications: Scientists study such compounds for their ability to inhibit certain enzymes that play crucial roles in cellular processes, which can lead to new treatments for infections and cancer.
  • Synthetic Pathways: The synthesis of this compound often involves a multi-step process, showcasing the intricate methods employed in organic chemistry to create complex molecules.
  • Historical Significance: Sulfonamides, discovered in the early 20th century, were among the first antibiotics used clinically, paving the way for modern antimicrobial therapy.
  • Future Prospects: Research is ongoing to explore new derivatives of this compound, aiming to enhance efficacy and reduce potential side effects in medical applications.

As scientists continue to unravel the complexities of compounds like 4-amino-N-(2,6-dimethylpyrimidin-4-yl)benzenesulfonamide, they open doors to innovative therapies that could significantly impact healthcare.

Synonyms
SULFISOMIDINE
sulfisomidin
515-64-0
Sulfaisodimidine
Sulphasomidine
Sulfasomidine
4-amino-N-(2,6-dimethylpyrimidin-4-yl)benzenesulfonamide
Domian
Sulfaisodimerazine
Solfisomidina
Sulfadimetine
Sulfaisodimidinum
Sulfaisomidine
Sulfisomidina
Aristamid
Aristogyn
Elcosine
Elkosil
Elkosin
Elkosine
Mefenal
Erycon
Sulfisomidinum
Isosulf
4-Sulfa-2,6-dimethylpyrimidine
2,6-Dimethyl-4-sulfanilamidopyrimidine
Sulfisomidine [JAN]
2,4-Dimethyl-6-sulfanilamidopyrimidine
4-Sulfanilamido-2,6-dimethylpyrimidine
6-Sulfanilamido-2,4-dimethylpyrimidine
Solfisomidina [DCIT]
Sulfisomidinum [INN-Latin]
Sulfisomidina [INN-Spanish]
6-(p-Aminobenzenesulfonamido)-2,4-dimethylpyrimidine
6-(4-Aminobenzenesulfonamido)-2,4-dimethylpyrimidine
6-(p-Aminobenzenesulfonyl)amino-2,4-dimethylpyrimidine
CHEBI:32166
Benzenesulfonamide, 4-amino-N-(2,6-dimethyl-4-pyrimidinyl)-
N(sup 1)-(2,6-Dimethyl-4-pyrimidinyl)sulfanilamide
EINECS 208-204-3
W03L3ODK6E
N1-(2,6-Dimethyl-4-pyrimidinyl)sulfanilamide
Sulfisomidine (TN)
BRN 0261305
Sulfisomidine [INN:BAN:JAN]
Sulfisomidine (JAN)
DTXSID1046390
AI3-50168
(p-Aminobenzolsulfonyl)-4-amino-2,6-dimethylpyrimidin
SULFISOMIDINE [MI]
N(1)-(2,6-Dimethyl-4-pyrimidinyl)sulfanilamide
SULFISOMIDINE [INN]
SULFISOMIDINE [MART.]
(p-Aminobenzolsulfonyl)-4-amino-2,6-dimethylpyrimidine
Sulfanilamide, N(sup 1)-(2,6-dimethyl-4-pyrimidinyl)-
SULFISOMIDINE [WHO-DD]
DTXCID9026390
YZMCKZRAOLZXAZ-UHFFFAOYSA-
(p-Aminobenzolsulfonyl)-4-amino-2,6-dimethylpyrimidin [German]
SULFISOMIDINE [EP IMPURITY]
5-25-10-00216 (Beilstein Handbook Reference)
NCGC00164492-01
Benzenesulfonamide, 4-amino-N-(2,6-dimethyl-4-pyrimidinyl)-(9CI)
Sulfisomidine 100 microg/mL in Acetonitrile
Sulfisomidinum (INN-Latin)
Sulfisomidina (INN-Spanish)
SULFISOMIDINE (MART.)
SULFISOMIDINE (EP IMPURITY)
CAS-515-64-0
UNII-W03L3ODK6E
Aristamide
Elcosin
Domain
MFCD00010567
Sulfisomidin (Standard)
sulfamethin;sulfaisodimidine
Oprea1_339670
SCHEMBL34791
MLS004773916
CHEMBL485696
HY-B1784R
4-amino-N-(2,6-dimethylpyrimidin-4-yl)benzene-1-sulfonamide
ALBB-023545
HY-B1784
Tox21_112130
BDBM50548727
s5291
STL481971
AKOS000119092
Tox21_112130_1
CCG-267227
CS-7658
DB13283
SB58524
NCGC00164492-02
NCGC00164492-03
NCGC00186655-01
AS-10637
SMR001346487
DB-051990
NS00010357
S0362
EN300-19077
A12593
D01526
SBI-0219880.0001
Sulfisomidin, VETRANAL(TM), analytical standard
SR-01000940235
Q6577315
SR-01000940235-2
F1716-0354
Z104472628
benzenesulfonamide, 4-amino-N(S)-(2,6-dimethylpyrimidin-4-yl)-
208-204-3