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4-amino-N-(3-methyl-2-pyridyl)benzamide

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Identification
Molecular formula
C13H13N3O
CAS number
54225-28-6
IUPAC name
4-amino-N-(3-methyl-2-pyridyl)benzamide
State
State

At room temperature, 4-amino-N-(3-methyl-2-pyridyl)benzamide exists as a solid. It is typically handled in a laboratory setting as a powder, allowing for easier measurement and mixing in experimental procedures.

Melting point (Celsius)
207.00
Melting point (Kelvin)
480.15
Boiling point (Celsius)
476.00
Boiling point (Kelvin)
749.15
General information
Molecular weight
227.27g/mol
Molar mass
227.2670g/mol
Density
1.2100g/cm3
Appearence

4-amino-N-(3-methyl-2-pyridyl)benzamide is a solid compound that generally appears as a crystalline powder. The color of this compound can vary depending on its pure state and particular form but typically it exists as an off-white or pale yellow powder.

Comment on solubility

Solubility of 4-amino-N-(3-methyl-2-pyridyl)benzamide

The solubility of 4-amino-N-(3-methyl-2-pyridyl)benzamide in various solvents is an intriguing topic, deserving detailed exploration. This compound features both polar and non-polar functional groups that influence its solubility characteristics.

Solvent Interactions

Considering its molecular structure, the solubility can generally be analyzed based on the following points:

  • Polarity: The presence of the amino group (-NH2) indicates that the compound can participate in hydrogen bonding, enhancing its solubility in polar solvents.
  • Non-polar Solvents: Given the aromatic ring and methyl group, 4-amino-N-(3-methyl-2-pyridyl)benzamide may exhibit some degree of solubility in non-polar organic solvents, although likely lower than in polar solvents.
  • pH Dependence: The solubility can be significantly affected by the pH of the solution, as protonation of the amino group can lead to increased solubility in acidic conditions.

General Trends

In broad terms, this compound might exhibit:

  1. High solubility in water: Due to the hydrogen-bonding capabilities of the amino group.
  2. Moderate to low solubility in ethanol or methanol: Also favoring polar environments.
  3. Limited solubility in hydrocarbons: A direct consequence of its comparatively polar nature.

Understanding these solubility patterns is vital for applications in pharmaceuticals and organic synthesis, allowing scientists to tailor conditions based on the solubility characteristics of 4-amino-N-(3-methyl-2-pyridyl)benzamide. As one might say, “Solubility is the key to reactivity,” and this compound is no exception!

Interesting facts

Interesting Facts About 4-amino-N-(3-methyl-2-pyridyl)benzamide

4-amino-N-(3-methyl-2-pyridyl)benzamide is a fascinating compound that belongs to the class of pharmaceuticals known as aminobenzamides. This compound is part of a larger family known for their significant roles in medicinal chemistry. Here are some intriguing aspects of this compound:

  • Pharmacological Potential: The presence of the amine and carbonyl groups in this compound suggest potential interactions with various biological targets, which may lead to significant therapeutic effects.
  • Diverse Applications: Compounds similar to 4-amino-N-(3-methyl-2-pyridyl)benzamide have been studied for their roles in treating conditions such as inflammation, cancer, and neurological disorders.
  • Structure-Activity Relationship (SAR): The unique arrangement of atoms, including the methyl group on the pyridine ring, provides insights into how modifications of the structure can influence biological activity. This is crucial for drug development.
  • Research Interest: Scientists are continually exploring the properties and effects of this compound, aiming to unlock its full potential. As stated by researchers, "Understanding the molecular interactions of derivatives can lead to innovative treatments."

This compound also serves as an excellent example of the importance of synthetic organic chemistry in developing new drugs. Each molecular modification can lead to different properties, emphasizing how chemistry can lead to groundbreaking advancements in medicine.

As research continues, compounds like 4-amino-N-(3-methyl-2-pyridyl)benzamide not only enhance our understanding of chemical interactions but also pave the way for new therapeutic discoveries.

Synonyms
Benzamide, p-amino-N-(3-methyl-2-pyridyl)-
2-(p-Aminobenzamido)-3-picoline
BRN 0479795
3-Picoline, 2-(p-aminobenzamido)-
3D4VL2Z9KU
Pyridine, 2-(p-aminobenzamido)-3-methyl-
DTXSID60170253
Benzamide, 4-amino-N-(3-methyl-2-pyridinyl)-
5-22-09-00281 (Beilstein Handbook Reference)
4-AMINO-N-(3-METHYL-2-PYRIDINYL)BENZAMIDE
DTXCID0092744
4-amino-N-(3-methylpyridin-2-yl)benzamide
17710-06-4
UNII-3D4VL2Z9KU
Oprea1_404110
Oprea1_551803
AKOS000205424
AG-690/09290023
SR-01000393916
SR-01000393916-1