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Sulfamethoxazole and Diethanolamine

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Identification
Molecular formula
C11H11N3O3S; C4H11NO2
CAS number
723-46-6; 111-42-2
IUPAC name
4-amino-N-(3,4-dimethylisoxazol-5-yl)benzenesulfonamide;2-(2-hydroxyethylamino)ethanol
State
State

At room temperature, Sulfamethoxazole is in a solid state as a crystalline powder, and Diethanolamine is a liquid.

Melting point (Celsius)
107.00
Melting point (Kelvin)
380.15
Boiling point (Celsius)
268.10
Boiling point (Kelvin)
541.25
General information
Molecular weight
253.28g/mol
Molar mass
253.2820g/mol
Density
1.1607g/cm3
Appearence

Sulfamethoxazole appears as a white crystalline powder. It is odorless and has a slightly bitter taste. Diethanolamine appears as a colorless liquid that may have a slight ammonia-like odor.

Comment on solubility

Solubility Characteristics

The compound 4-amino-N-(3,4-dimethylisoxazol-5-yl)benzenesulfonamide;2-(2-hydroxyethylamino)ethanol exhibits notable considerations regarding its solubility, which can be influenced by several factors. Understanding these aspects is essential for applications and experimentation.

Key Factors Influencing Solubility

  • Polarity: The presence of sulfonamide and hydroxyethylamino groups in the structure generally increases the polarity of the molecule, enhancing its solubility in polar solvents like water.
  • Hydrogen Bonding: The ability to form hydrogen bonds with water molecules can further promote solubility, particularly due to the hydroxyl group present.
  • pH Sensitivity: The solubility could be pH-dependent, as the ionization of certain functional groups may vary with pH changes, affecting overall solubility.

Overall, it is often observed that:

  • This compound is likely to be soluble in aqueous solutions, making it suitable for biological studies.
  • It may also exhibit varying solubility in organic solvents, depending on their polarity.

In summary, while there is potential for significant solubility, specific experimental conditions should be considered to optimize the solubility of this compound. As noted, "Understanding solubility not only informs synthesis but also facilitates application in various chemical domains."

Interesting facts

Interesting Facts about 4-amino-N-(3,4-dimethylisoxazol-5-yl)benzenesulfonamide; 2-(2-hydroxyethylamino)ethanol

This intriguing compound consists of two distinct structural components, each contributing unique properties that make it notable in the field of chemistry and pharmaceuticals.

Structural Characteristics

  • Isolated Components: The compound contains a sulfonamide moiety, which is often associated with antibacterial properties, and a hydroxyethylamino group that can enhance water solubility.
  • Isoxazole Ring: The presence of the 3,4-dimethylisoxazol-5-yl group indicates potential efficacy in various chemical behaviors, especially in medicinal chemistry.

Applications

This compound has potential applications in various fields including:

  • Pharmaceuticals: Due to its sulfonamide component, it is of interest for developing new antibiotics.
  • Chemical Research: Researchers explore its properties to understand reactions that involve sulfonamides and other nitrogen-containing compounds.
  • Biological Studies: It can be used to study aminated compounds and their biological interactions.

Quote from the Field

As noted by chemists exploring similar compounds, “Understanding the nuances of mixed functional groups can lead to breakthroughs in drug design and efficacy.” This reflects the value of investigating compounds with dual functionalities such as this one.

Future Prospects

The dual nature of the compound opens up numerous avenues for further research:

  • Drug Development: It could result in advancements in treating various bacterial infections.
  • Research Opportunities: The compound paves the way for novel synthetic pathways in organic chemistry.

In summary, the compound 4-amino-N-(3,4-dimethylisoxazol-5-yl)benzenesulfonamide; 2-(2-hydroxyethylamino)ethanol is not just a fascinating entity in its own right but a promising platform for further scientific exploration and innovation.

Synonyms
SULFISOXAZOLE DIOLAMINE
4299-60-9
Sulfafurazole diolamine
Sulfafurazol 2,2'-imidodiethanol
Sulphafurazole diolamine
Sulfafurazole diethanolamine
EINECS 224-308-1
NU-445
UNII-30S4B46J8B
30S4B46J8B
Sulfisoxazole diolamine [USAN:USP]
sulfisoxazole diethanolamine
SULFISOXAZOLE DIETHANOLAMINE SALT
CHEBI:88263
DTXSID90195616
N(sup 1)-(3,4-Dimethyl-5-isoxazolyl)sulfanilamide compound with 2,2'-iminodiethanol (1:1)
Sulfisoxazole diolamine (USAN:USP)
SULFAFURAZOLE DIOLAMINE (MART.)
SULFAFURAZOLE DIOLAMINE [MART.]
4-amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzene-1-sulfonamide--2,2'-azanediyldi(ethan-1-ol) (1/1)
Diolamine, Sulfisoxazole
DTXCID30118107
224-308-1
Sulfisoxazole diolamine [USAN]
Sulfisoxazole (diethanolamine)
4-amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide;2-(2-hydroxyethylamino)ethanol
N-(3,4-Dimethylisoxazol-5-yl)sulphanilamide, compound with 2,2'-iminodiethanol (1:1)
Gantrisin (TN)
Sulfisoxazole diolamine (USAN)
Sulfisoxazoldiolamin
Ammonium Salt Sulfisoxazole
SCHEMBL23466
CHEMBL1200321
HY-B0323A
SULFISOXAZOLE DIOLAMINE [VANDF]
DA-75847
CS-0030851
NS00083192
SULFAFURAZOLE DIETHANOLAMINE [WHO-DD]
SULFISOXAZOLE DIOLAMINE [ORANGE BOOK]
SULFISOXAZOLE DIETHANOLAMINE SALT [MI]
D05957
Q27160153