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Kanamycin A

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Identification
Molecular formula
C18H36N4O11
CAS number
59-01-8
IUPAC name
4-amino-N-[5-amino-2-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-4-[6-(aminomethyl)-3,4,5-trihydroxy-tetrahydropyran-2-yl]oxy-3-hydroxy-cyclohexyl]-2-hydroxy-butanamide
State
State

At room temperature, Kanamycin A is a solid.

Melting point (Celsius)
190.00
Melting point (Kelvin)
463.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
484.53g/mol
Molar mass
485.4740g/mol
Density
1.5000g/cm3
Appearence

Kanamycin A typically appears as a white to off-white powder. It is often available in a crystalline form.

Comment on solubility

Solubility of 4-amino-N-[5-amino-2-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-4-[6-(aminomethyl)-3,4,5-trihydroxy-tetrahydropyran-2-yl]oxy-3-hydroxy-cyclohexyl]-2-hydroxy-butanamide

The solubility of the compound 4-amino-N-[5-amino-2-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-4-[6-(aminomethyl)-3,4,5-trihydroxy-tetrahydropyran-2-yl]oxy-3-hydroxy-cyclohexyl]-2-hydroxy-butanamide (C18H36N4O11) is an intriguing subject, primarily due to its complex structure. This compound exhibits significant potential for solubility in polar solvents. Here’s a breakdown of factors contributing to its solubility:

  • Hydroxyl Groups: The presence of numerous hydroxyl (–OH) groups enhances its ability to form hydrogen bonds with water, significantly increasing solubility.
  • Amino Groups: The amino (–NH2) groups further promote solubility through ionic interactions and hydrogen bond formation.
  • Structural Configuration: The tetrahydropyran rings and cyclohexyl moieties suggest that the compound may have a hydrophilic character, aiding its dissolution in aqueous environments.

However, it's important to note that solubility can also be influenced by temperature and pH of the solution. As a general observation, compounds enriched with multiple functional groups are often more soluble than their counterparts. According to various studies, compounds similar to this one are typically soluble in:

  • Water
  • Alcohols (e.g., ethanol)
  • Buffering solutions, especially under physiological conditions.

In conclusion, the intricate balance of hydrophilic functionalities within this compound implies a high potential for solubility in polar solvents, making it suitable for applications in areas such as pharmaceuticals and biochemical research.

Interesting facts

Interesting Facts about 4-amino-N-[5-amino-2-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-4-[6-(aminomethyl)-3,4,5-trihydroxy-tetrahydropyran-2-yl]oxy-3-hydroxy-cyclohexyl]-2-hydroxy-butanamide

This complex compound is part of a broader class of organic compounds known for their multifunctional properties. With a structure featuring multiple amino and hydroxy groups, this molecule is of particular interest in the field of medicinal chemistry. Here are some key points to highlight its significance:

  • Biological Significance: The presence of multiple amino and hydroxyl groups enhances its potential as a pharmacophore, which could lead to important biological activities.
  • Potential Applications: This compound may serve as a candidate for drug development, especially in the treatment of diseases requiring enhanced solubility and stability.
  • Synthetic Challenges: The synthesis of such molecules often involves intricate multi-step procedures which can be both rewarding and challenging for chemists.
  • Structure-Activity Relationship (SAR): Analyzing how each functional group contributes to the overall activity can be a pivotal study in medicinal chemistry.
  • Interdisciplinary Research: This compound exemplifies the intersection of organic chemistry, pharmacology, and biochemistry in modern research.

As a student or researcher, exploring such compounds can broaden understanding of molecular interactions and inspire innovative therapeutic approaches. The intricate design of this compound reminds scientists of the beauty and complexity of chemistry, often summarized in the words of Albert Einstein: "Everything should be made as simple as possible, but no simpler."

In conclusion, the study of such compounds not only enriches our knowledge of chemistry but also holds the promise of advancing healthcare solutions. Keep an eye on the ongoing research in this area as we continue to uncover the vast potential these molecules may hold!

Synonyms
Briclin
Liposomal Amikacin
ANTIBIOTIC BB-K8
4-amino-n-{5-amino-2-[(3-amino-3-deoxyhexopyranosyl)oxy]-4-[(6-amino-6-deoxyhexopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanamide
SCHEMBL13260939
DTXSID60860546
HMS3604B03