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Kanamycin A

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Identification
Molecular formula
C18H36N4O11
CAS number
59-01-8
IUPAC name
4-amino-N-[5-amino-4-[3-amino-6-(aminomethyl)-4,5-dihydroxy-tetrahydropyran-2-yl]oxy-3-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]oxy-2-hydroxy-cyclohexyl]-2-hydroxy-butanamide
State
State

Kanamycin A is typically a solid at room temperature, appearing as a crystalline powder. Its solid state allows it to be formulated as capsules or tablets for oral administration or as an injectable solution after dissolving in the appropriate solvent.

Melting point (Celsius)
270.00
Melting point (Kelvin)
543.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
484.48g/mol
Molar mass
484.4750g/mol
Density
1.7000g/cm3
Appearence

Kanamycin A typically appears as a white or off-white powder. It is generally crystalline in nature and is soluble in water, forming clear solutions. It is commonly supplied in a sulfate or monosulfate form for pharmaceutical usage.

Comment on solubility

Solubility of 4-amino-N-[5-amino-4-[3-amino-6-(aminomethyl)-4,5-dihydroxy-tetrahydropyran-2-yl]oxy-3-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]oxy-2-hydroxy-cyclohexyl]-2-hydroxy-butanamide

The solubility of 4-amino-N-[5-amino-4-[3-amino-6-(aminomethyl)-4,5-dihydroxy-tetrahydropyran-2-yl]oxy-3-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]oxy-2-hydroxy-cyclohexyl]-2-hydroxy-butanamide (C18H36N4O11) is influenced by various factors including its complex structure and functional groups involved. Key considerations regarding solubility include:

  • Hydrophilicity vs. Hydrophobicity: The presence of numerous hydroxyl groups in the molecule indicates that it possesses significant hydrophilic characteristics, which can enhance its solubility in polar solvents like water.
  • Amine Groups: The amine functional groups can also contribute to its solubility behavior, as they may engage in hydrogen bonding with solvents, further increasing its solubility potential.
  • Structural Complexity: The intricate arrangement of multiple rings and substituents can lead to variations in solubility depending on the solvent used.
  • Solvent Interaction: In general, this compound is more likely to dissolve in polar solvents compared to non-polar solvents due to its overall polarity and the ability to form hydrogen bonds.

In conclusion, the solubility of C18H36N4O11 is expected to be substantial in water and other polar solvents, which can be critical in its applications and interactions within various environments.

Interesting facts

Interesting Facts about 4-amino-N-[5-amino-4-[3-amino-6-(aminomethyl)-4,5-dihydroxy-tetrahydropyran-2-yl]oxy-3-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]oxy-2-hydroxy-cyclohexyl]-2-hydroxy-butanamide

This complex compound is a fascinating example of how intricate molecular structures can lead to diverse biochemical interactions. Here are some noteworthy points about this molecule:

  • Multi-functional Groups: This compound contains multiple amino groups and hydroxyl groups, which enhance its reactivity and solubility in various solvents, making it an interesting candidate for applications in pharmaceuticals and biochemistry.
  • Sugar Moieties: The presence of sugar-like structures, such as the tetrahydropyran and tetrahydrofuran rings, indicates potential biological activities. These components are often involved in drug delivery systems, mimicking natural biological processes.
  • Potential Therapeutic Uses: Compounds with such structural complexity are often investigated for their roles in enzyme inhibition or as potential therapeutic agents. Researchers are keen to explore its ability to influence metabolic pathways.
  • Analogous to Natural Compounds: The resemblance to naturally occurring compounds, particularly in the way it mimics polysaccharides, opens avenues for new discoveries in medicinal chemistry.
  • Research Field: This molecule's intricate design is often a point of study in the fields of organic chemistry, medicinal chemistry, and biochemistry, as scientists seek to understand its potential application in drug design.

In conclusion, 4-amino-N-[5-amino-4-[3-amino-6-(aminomethyl)-4,5-dihydroxy-tetrahydropyran-2-yl]oxy-3-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]oxy-2-hydroxy-cyclohexyl]-2-hydroxy-butanamide serves as an inspiring example of the complexities found in modern chemistry. Its structural characteristics not only provide insight into molecular design but also underline its potential as a significant player in the development of new therapeutic modalities.

Synonyms
4-amino-n-{5-amino-4-[(2,6-diamino-2,6-dideoxyhexopyranosyl)oxy]-2-hydroxy-3-(pentofuranosyloxy)cyclohexyl}-2-hydroxybutanamide
Butirosin
SCHEMBL19944113
DTXSID40860625