Sulfamethizole | Solubility of Things

Identification

Molecular formula

C₉H₁₀N₄O₂S₂

CAS number

144-82-1

IUPAC name

4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide

State

At room temperature, sulfamethizole is in a solid state, typically formulated as a powder for pharmaceutical applications.

Melting point (Celsius)

202.00

Melting point (Kelvin)

475.15

Boiling point (Celsius)

760.00

Boiling point (Kelvin)

1 033.15

General information

Molecular weight

270.34g/mol

Molar mass

270.3370g/mol

Density

1.4700g/cm³

Appearence

Sulfamethizole is typically encountered as a white to light yellow powder. It may be slightly odorous and is crystalline in nature, maintaining consistent structural properties under standard conditions.

Comment on solubility

Solubility of 4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide

The solubility of 4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide, with the chemical formula C₉H₁₀N₄O₂S₂, presents interesting characteristics:

Water Solubility: This compound is generally considered to have moderate solubility in water. Its sulfonamide group enhances water solubility due to hydrogen bonding capabilities.
Organic Solvents: It is often soluble in a range of organic solvents, including ethanol and dimethyl sulfoxide (DMSO), which can aid in various applications and formulations.
pH Dependence: The solubility may vary with pH; in more acidic or basic conditions, the compound may ionize or precipitate differently, affecting its solubility landscape.
Temperature Influence: Like many compounds, an increase in temperature typically results in an increase in solubility, allowing for more effective dissolution.

Overall, the solubility of 4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide is influenced by several factors, making it versatile for various chemical applications. Understanding these solubility properties is crucial for optimizing its use in the laboratory and industrial processes.

Interesting facts

4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide

This intriguing compound, known as 4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide, is a member of a class of sulfonamides that has garnered considerable attention in the fields of pharmaceuticals and agrochemicals. Here are some fascinating aspects of this compound:

Pharmaceutical Applications: Sulfonamides have been utilized as antibiotics since the early 20th century. They inhibit bacterial growth by blocking the synthesis of folic acid, vital for DNA and RNA production in bacteria.
Mechanism of Action: The compound's action involves mimicking p-aminobenzoic acid (PABA), a substrate needed for bacterial folate synthesis. By competing for this critical enzyme, sulfonamides effectively *stifle* bacterial growth.
Thiadiazole Linkage: The presence of the thiadiazole ring in this compound not only enhances its pharmacological properties but also contributes to its potential biological activities, including antimicrobial and anti-inflammatory effects.
Applications Beyond Medicine: Research indicates that compounds like this one may also serve in the development of herbicides or pesticides, showcasing their importance in agricultural chemistry.
Structure-Activity Relationship (SAR): Studying the variations in the structure of similar compounds helps chemists design new drugs with improved efficacy and decreased side effects, making this compound valuable for ongoing research in medicinal chemistry.

In summary, 4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide is not just a chemical formula but a gateway to myriad possibilities in medicine and agriculture. Its multifaceted properties exemplify the intricate relationship between chemical structure and biological function, which remains a critical area of study in chemistry.

Synonyms

sulfamethizole

144-82-1

Sulfamethizol

Sulphamethizole

Thiosulfil

Rufol

Sulfametizol

Proklar

Sulfamethylthiadiazole

4-Amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide

Sulfamethizolum

Sulfurine

Ayerlucil

Methazol

Microsul

Sulfapyelon

Sulfstat

Tetracid

Thidicur

Ultrasul

Urocydal

Urodiaton

Urolucosil

Urosulfin

Lucosil

Renasul

Salimol

Famet

Uroz

Sulfa gram

Solfametizolo

Sulfametizol [INN-Spanish]

RP 2145

Sulfamethizolum [INN-Latin]

Benzenesulfonamide, 4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)-

VK 53

4-Amino-N-(5-Methyl-1,3,4-Thiadiazol-2-Yl)Benzene-1-Sulfonamide

CCRIS 756

sulphamethazole

CHEBI:9331

sulphamethiozole

Sulfamethizole (Proklar)

HSDB 4379

2-(p-Aminobenzenesulfonamido)-5-methylthiadiazole

EINECS 205-641-1

2-Methyl-5-sulfanilamido-1,3,4-thiadiazole

2-Sulfanilamido-5-methyl-1,3,4-thiadiazole

5-Methyl-2-sulfanilamido-1,3,4-thiadiazole

NSC-757327

DTXSID5023615

N1-(5-Methyl-1,3,4-thiadiazol-2-yl)sulfanilamide

AI3-50149

UNII-25W8454H16

N(sup 1)-(5-Methyl-1,3,4-thiadiazol-2-yl)-sulfanilamide

CHEMBL1191

MLS000028603

DTXCID803615

N(sup 1)-(5-Methyl-1,3,4-thiadiazol-2-yl)sulfanilamide

25W8454H16

Solfametizolo [DCIT]

Sulfamethizole [USP:INN:BAN:JAN]

N(1)-(5-Methyl-1,3,4-thiadiazol-2-yl)sulfanilamide

NSC 757327

NCGC00016407-05

NCGC00016407-08

CAS-144-82-1

SMR000058666

Sulfanilamide, N(sup 1)-(5-methyl-1,3,4-thiadiazol-2-yl)-

Sulfametizol (INN-Spanish)

Sulfamethizolum (INN-Latin)

Thiosulfil-A-Forte

SULFAMETHIZOLE (MART.)

SULFAMETHIZOLE [MART.]

SULFAMETHIZOLE (USP-RS)

SULFAMETHIZOLE [USP-RS]

SULFAMETHIZOLE (EP IMPURITY)

Sulfamethizole (USP:INN:BAN:JAN)

SULFAMETHIZOLE [EP IMPURITY]

N (SUP 1)-(5-METHYL-1,3,4-THIADIAZOL-2-YL)SULFANILAMIDE

SULFAMETHIZOLE (EP MONOGRAPH)

SULFAMETHIZOLE [EP MONOGRAPH]

SULFAMETHIZOLE (USP MONOGRAPH)

SULFAMETHIZOLE [USP MONOGRAPH]

Thiosulfil (TN)

SR-01000003158

sulfametizolo

4-aminomethyl-1-n-boc-piperidine

Prestwick_114

MFCD00053363

Spectrum_000992

Opera_ID_1595

Prestwick0_000742

Prestwick1_000742

Prestwick2_000742

Prestwick3_000742

Spectrum2_001322

Spectrum3_000570

Spectrum4_000640

Spectrum5_001078

Sulfamethizole (Standard)

Epitope ID:122233

SULFAMETHIZOLE [MI]

SULFAMETHIZOLE [INN]

SULFAMETHIZOLE [JAN]

SCHEMBL26453

BSPBio_000724

BSPBio_001960

KBioGR_001260

KBioSS_001472

SULFAMETHIZOLE [HSDB]

MLS002303066

DivK1c_000141

SPECTRUM1500549

SULFAMETHIZOLE [VANDF]

SPBio_001443

SPBio_002663

Sulfamethizole-(phenyl-13C6)

BPBio1_000798

SULFAMETHIZOLE [WHO-DD]

GTPL12683

HMS500H03

HY-B0333R

KBio1_000141

KBio2_001472

KBio2_004040

KBio2_006608

KBio3_001460

B05CA04

D06BA04

J01EB02

S01AB01

NINDS_000141

Sulfamethizole (JP17/USP/INN)

HMS1570E06

HMS1921A19

HMS2092I21

HMS2097E06

HMS2233L09

HMS3371A13

HMS3655F05

HMS3714E06

Pharmakon1600-01500549

HY-B0333

SULFAMETHIZOLE [ORANGE BOOK]

Tox21_110425

Tox21_201035

BDBM50295558

CCG-39260

NSC757327

s1957

AKOS002666345

Tox21_110425_1

DB00576

IDI1_000141

SMP1_000284

NCGC00016407-01

NCGC00016407-02

NCGC00016407-03

NCGC00016407-04

NCGC00016407-06

NCGC00016407-07

NCGC00016407-09

NCGC00016407-11

NCGC00016407-13

NCGC00024107-03

NCGC00024107-04

NCGC00024107-05

NCGC00258588-01

AS-10177

DA-58172

SBI-0051523.P003

AB00052098

NS00000005

SW196425-3

Sulfamethizol 1000 microg/mL in Acetonitrile

C08050

D00870

D88000

EN300-217740

1,3,4-Thiadiazole, 5-methyl-2-sulphanilamido-

AB00052098_15

AB00052098_16

Sulfamethizole, VETRANAL(TM), analytical standard

Q3976824

SR-01000003158-2

SR-01000003158-3

Sulfamethizole, analytical standard, >=99% (HPLC)

BRD-K31682896-001-05-9

BRD-K31682896-001-15-8

BRD-K31682896-001-23-2

BRD-K31682896-001-24-0

Sulfamethizole, European Pharmacopoeia (EP) Reference Standard

4-amino-N-(5-methyl[1,3,4]thiadiazol-2-yl)-benzenesulfonamide

N(SUP1)-(5-METHYL-1,3,4-THIADIAZOL-2-YL)SULFANILIMIDE

Sulfamethizole, United States Pharmacopeia (USP) Reference Standard

SULFANILAMIDE, N(1)-(5-METHYL-1,3,4-THIADIAZOL-2-YL)-

4-AMINO-N-(5-METHYL-1,3,4-THIADIAZOL-2-YL)BENZENESULFONIMIDE

205-641-1