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Acetosulfamide

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Identification
Molecular formula
C12H16N4O2S2
CAS number
657-24-9
IUPAC name
4-amino-N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide
State
State

At room temperature, acetosulfamide is typically in a solid state, found as a crystalline powder. It is stable under normal temperatures and pressures.

Melting point (Celsius)
235.00
Melting point (Kelvin)
508.15
Boiling point (Celsius)
320.00
Boiling point (Kelvin)
593.15
General information
Molecular weight
323.44g/mol
Molar mass
323.4410g/mol
Density
1.4598g/cm3
Appearence

Acetosulfamide appears as a white or almost white crystalline powder. Its crystalline nature and lack of color make it easily identifiable in its pure form.

Comment on solubility

Solubility of 4-amino-N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide

The solubility of 4-amino-N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide exhibits some interesting characteristics that are worth noting. Generally, the solubility of this compound can be influenced by various factors, including:

  • Polarity: The presence of the sulfonamide group enhances the polarity of the molecule, which generally increases solubility in polar solvents such as water.
  • Functional Groups: The amino group contributes to hydrogen bonding, thus improving its ability to dissolve in aqueous solutions.
  • Alkyl Substituents: The tert-butyl group can render the compound more hydrophobic, which may reduce solubility in some cases.

Overall, solubility is a complex interplay of these various features, leading to the conclusion that:

  1. The compound may show moderate solubility in water.
  2. It is likely to be more soluble in organic solvents, reflecting the hydrophobic regions introduced by the tert-butyl group.

In practical applications, understanding the solubility profile is crucial, as it affects the compound's bioavailability and its interactions in different environments. As the quote goes, "Solubility is the key to chemistry's door."

Interesting facts

Interesting Facts about 4-amino-N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide

4-amino-N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide, often referred to in shortened forms, is a compound that piques the interest of chemists due to its unique structure and properties. Here are some fascinating aspects of this intriguing compound:

  • Pharmaceutical Potential: The compound features a sulfonamide group, which is known for its antibiotic properties. Many sulfonamides serve as key components in medications, making compounds like this one significant in drug discovery.
  • Diverse Applications: Beyond pharmaceuticals, its formulation can be utilized in agricultural chemistry, specifically as a potential herbicide and fungicide.
  • Structural Complexity: The incorporation of a thiadiazole ring provides intriguing electronic properties that can enhance the compound's ability to interact with biological molecules. Understanding this interaction can lead to the development of more effective therapeutics.
  • Research Opportunities: The compound serves as an interesting candidate for study within the fields of synthetic chemistry and medicinal chemistry. Its unique combination of an amino group and thiadiazole can be pivotal in exploring new synthetic pathways.
  • Mechanistic Insights: Studying the mechanism of action in which this compound interacts with biological systems can provide insight into not only its effectiveness but also potential side effects, forming a cornerstone in the development of safer drugs.

In the world of chemistry, compounds like 4-amino-N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide not only contribute to the molecular understanding but also underscore the importance of structure-function relationships in developing valuable applications in health and agriculture. It's a classic example where a single compound can hold the key to various scientific advancements!

Synonyms
Glybuthiazol
GLYBUTHIAZOLE
Glipasol
Glypasol
Glybuthizolum
Glibutiazol
Glybuthiazolum
RP 2259
Glybuthiazol [INN:DCF]
Glibutiazol [INN-Spanish]
Glybuthiazolum [INN-Latin]
2259 RP
p-Aminobenzenesulfamido-tert-butylthiodiazol
EINECS 208-615-8
NSC 23010
NSC-23010
RP-2259
BRN 0033849
Glybuthiazol (INN)
GLYBUTHIZOL
DTXSID4057762
UNII-35421N8E8W
2259 R. P.
GLYBUTHIAZOL [INN]
GLYBUTHIAZOLE [MI]
35421N8E8W
2259 R.P.
DTXCID5031551
N(sup 1)-(5-tert-Butyl-1,3,4-thiadiazol-2-yl)sulfanilamide
4-27-00-08085 (Beilstein Handbook Reference)
Benzenesulfonamide, 4-amino-N-(5-(1,1-dimethylethyl)-1,3,4-thiadiazol-2-yl)-
Sulfanilamide, N1-(5-tert-butyl-1,3,4-thiadiazol-2-yl)-
Sulfanilamide, N(sup 1)-(5-tert-butyl-1,3,4-thiadiazol-2-yl)-
Glibutiazol (INN-Spanish)
Glybuthiazolum (INN-Latin)
Sulfanilamide, N1-(5-tert-butyl-1,3,4-thiadiazol-2-yl)-(8CI)
Benzenesulfonamide, 4-amino-N-(5-(1,1-dimethylethyl)-1,3,4-thiadiazol-2-yl)-(9CI)
208-615-8
535-65-9
4-amino-N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide
N1-(5-tert-Butyl-1,3,4-thiadiazol-2-yl)sulfanilamide
CHEMBL94087
SCHEMBL282607
CHEBI:135337
NSC23010
Tox21_113930
4-Amino-N-[5-(1,1-dimethylethyl)-1,3,4-thiadiazol-2-yl]benzenesulfonamide
Sulfanilamide,3,4-thiadiazol-2-yl)-
NCGC00262937-01
CAS-535-65-9
DB-212625
NS00032788
D02462
Q27256420
Benzenesulfonamide,1-dimethylethyl)-1,3,4-thiadiazol-2-yl]-