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Sulfamethoxypyrimidine

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Identification
Molecular formula
C11H13N3O3S
CAS number
651-06-9
IUPAC name
4-amino-N-(6-methoxy-2-methyl-pyrimidin-4-yl)benzenesulfonamide
State
State

At room temperature, sulfamethoxypyrimidine is in a solid state. It is typically handled in this form for various uses, especially in pharmaceuticals where it acts as an antimicrobial agent.

Melting point (Celsius)
197.00
Melting point (Kelvin)
470.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
280.32g/mol
Molar mass
280.3170g/mol
Density
1.5400g/cm3
Appearence

Sulfamethoxypyrimidine usually appears as a white to off-white crystalline powder. Its crystalline nature gives it a solid appearance with a slightly granular texture. The compound is typically refined into a fine powder suitable for pharmaceutical formulations.

Comment on solubility

Solubility of 4-amino-N-(6-methoxy-2-methyl-pyrimidin-4-yl)benzenesulfonamide

The solubility of 4-amino-N-(6-methoxy-2-methyl-pyrimidin-4-yl)benzenesulfonamide can be influenced by several factors due to its structural characteristics. This compound contains a sulfonamide moiety which typically enhances its solubility in polar solvents.

Key Points on Solubility:

  • Solvent Compatibility: The presence of both amino and methoxy groups favor solubility in water and other polar solvents.
  • pH Influence: Changes in pH can significantly affect ionization and thus solubility, with higher pH levels potentially increasing solubility.
  • Temperature Effect: As with many organic compounds, increasing temperature may help increase solubility.

However, it's important to note that, as with many sulfonamides, there might be limited solubility in non-polar solvents. As a general rule, "like dissolves like," meaning non-polar compounds will struggle to dissolve in polar solvents.

In conclusion, while 4-amino-N-(6-methoxy-2-methyl-pyrimidin-4-yl)benzenesulfonamide may exhibit reasonable solubility in water and common organic solvents, its precise solubility can vary with environmental conditions and the solvent used.

Interesting facts

Interesting Facts about 4-amino-N-(6-methoxy-2-methyl-pyrimidin-4-yl)benzenesulfonamide

The compound known as 4-amino-N-(6-methoxy-2-methyl-pyrimidin-4-yl)benzenesulfonamide belongs to a fascinating class of sulfonamide compounds, which have made significant contributions to various fields of chemistry and medicine. Here are some noteworthy points about this intriguing compound:

  • Pharmacological Significance: Sulfonamides, including this compound, have been widely used as antibiotics. Their discovery played a crucial role in the development of modern medicine.
  • Structure-Activity Relationship: The specific substitution patterns in this compound, such as the methoxy group and the pyrimidine ring, can greatly influence its biological activity and efficacy.
  • Research Applications: Compounds like this one are often investigated for their potential as therapeutic agents in treating bacterial infections, as well as in oncology for targeting cancer cells.
  • Mechanism of Action: The compound may act through competitive inhibition of bacterial enzymes involved in folate synthesis, which is vital for bacterial growth and replication.
  • Collaboration of Fields: Studying such compounds often requires interdisciplinary approaches, combining concepts from organic chemistry, pharmacology, and medicinal chemistry.

As you delve deeper into the world of 4-amino-N-(6-methoxy-2-methyl-pyrimidin-4-yl)benzenesulfonamide, keep in mind the broader implications of its research and development. Each innovation in the realm of sulfonamides not only enhances our understanding of chemistry but also holds the potential to improve health outcomes globally.

Synonyms
Sulfametomidine
SULFAMETHOMIDINE
Duroprocin
Methofadin
Methofazine
Sulfametomidina
Solfametomidina
Sulfametomidinum
Solfametomidina [DCIT]
Sulfametomidine [INN:DCF]
Sulfametomidinum [INN-Latin]
Sulfametomidina [INN-Spanish]
UNII-940ZL3AHKB
4-amino-N-(6-methoxy-2-methylpyrimidin-4-yl)benzenesulfonamide
EINECS 223-219-5
SA 412
BRN 0284949
DTXSID0023616
4-Sulfanilamido-6-methoxy-2-methylpyrimidin
N1-(6-Methoxy-2-methyl-4-pyrimidinyl)sulfanilamid
SULFAMETHOMIDINE [MI]
SULFAMETOMIDINE [INN]
SULFAMETOMIDINE [JAN]
DTXCID203616
SULFAMETOMIDINE [WHO-DD]
4-Amino-N-(6-methoxy-2-methyl-4-pyrimidinyl)benzenesulfonamide
Benzenesulfonamide, 4-amino-N-(6-methoxy-2-methyl-4-pyrimidinyl)-
(p-Aminobenzolsulfonyl)-4-amino-2-methyl-6-methoxy-pyrimidin [German]
5-25-13-00006 (Beilstein Handbook Reference)
Sulfametomidine (JAN)
(p-Aminobenzolsulfonyl)-4-amino-2-methyl-6-methoxy-pyrimidin
Sulfanilamide, N(sup 1)-(6-methoxy-2-methyl-4-pyrimidinyl)-
Sulfametomidinum (INN-Latin)
Sulfametomidina (INN-Spanish)
Telemid
3772-76-7, anhydride
J01ED03
4-amino-N-(6-methoxy-2-methylpyrimidin-4-yl)benzene-1-sulfonamide
Benzenesulfonamide, 4-amino-N-(6-methoxy-2-methyl-4-pyrimidinyl)-(9CI)
223-219-5
3772-76-7
940ZL3AHKB
NCGC00183014-01
Sulfametomidine; Telemid ; Duroprocin; Methofadin
Sulfametomidin
N1-(6-Methoxy-2-methyl-4-pyrimidinyl)sulfanilamide
SCHEMBL151238
CHEMBL485940
CHEBI:32163
GTPL12701
N(sup 1)-(6-Methoxy-2-methyl-4-pyrimidinyl)sulfanilamide
QKLSCPPJEVXONT-UHFFFAOYSA-N
Tox21_113296
DB13485
DA-58174
CAS-3772-76-7
HY-105838
4-sulfanilamido-2-methyl-6-methoxypyrimidine
CS-0026757
NS00011878
Q6577319
4-amino-N-[2-methyl-6-(methyloxy)pyrimidin-4-yl]benzenesulfonamide