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Sulfamethoxypyridazine

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Identification
Molecular formula
C11H12N4O3S
CAS number
86-14-0
IUPAC name
4-amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide
State
State

At room temperature, sulfamethoxypyridazine is typically in a solid state, appearing as a crystalline powder.

Melting point (Celsius)
209.00
Melting point (Kelvin)
482.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
280.31g/mol
Molar mass
280.3110g/mol
Density
1.4950g/cm3
Appearence

Sulfamethoxypyridazine appears as a white to yellowish crystalline powder. It is poorly soluble in water but soluble in acetone and dimethylformamide. The compound is used primarily as an antibacterial agent.

Comment on solubility

Solubility of 4-amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

The solubility of 4-amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (C11H12N4O3S) is influenced by several factors, primarily its chemical structure and functional groups. This compound contains both an amino group and a sulfonamide group, which can impact interactions with solvents. Here are some key considerations regarding its solubility:

  • Polarity: The presence of polar groups, such as the amino and sulfonamide functionalities, may enhance solubility in polar solvents like water.
  • Hydrogen Bonding: The ability to form hydrogen bonds with water can facilitate solubility, which is essential for bioavailability in pharmacological contexts.
  • Solvent Choice: While it might exhibit good solubility in water, the compound may also have compatibility with organic solvents depending on the solvation environment.
  • Concentration Effects: As with many organic compounds, solubility can vary significantly with concentration, often requiring careful adjustments in formulation.

In terms of practical applications, solubility is crucial as it dictates the effectiveness of the compound in biological systems. As such, it is often stated that "solubility is the key that unlocks the potential of a compound in pharmaceutical applications." Understanding these solubility characteristics can provide significant insights into the compound's behavior in various environments.

Interesting facts

Interesting Facts about 4-amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

This fascinating compound, commonly referred to in the scientific community, combines various functional groups that contribute to its unique properties and potential applications. Here are some engaging insights:

  • Pharmacological Potential: Compounds like 4-amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide have been studied for their antimicrobial and anti-inflammatory properties, making them candidates for pharmaceutical development.
  • Pyrimidine Base: The presence of the pyrimidine ring plays a crucial role in the compound's biological activity, as pyrimidines are known to partake in the structure of nucleic acids and are essential in cellular processes.
  • Sulfonamide Moiety: This compound belongs to the sulfonamide class of drugs, which are renowned for their antibacterial effects. Sulfonamides inhibit bacterial folate synthesis, a vital metabolic pathway.
  • Research Utility: Compounds like this are often utilized in research for drug design due to their structural versatility. Understanding how modifications affect activity can lead to more effective therapeutics.
  • Interdisciplinary Applications: The integration of organic, medicinal, and computational chemistry enriches the study of this compound, opening pathways for innovations in both drug development and synthetic methodologies.

In summary, 4-amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide is not just an intersection of various chemical functionalities but also a potential key player in medical advancements!

Synonyms
sulfamonomethoxine
1220-83-3
Sulfamonomethoxin
Daimeton
4-amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide
Sulfamonmethoxine
Sulfamonometoxina
Benzenesulfonamide, 4-amino-N-(6-methoxy-4-pyrimidinyl)-
Sulfamonomethoxinum
4-Amino-N-(6-methoxy-4-pyrimidinyl)benzenesulfonamide
N1-(6-Methoxy-4-pyrimidinyl)sulfanilamide
4-amino-N-(6-methoxypyrimidin-4-yl)benzene-1-sulfonamide
MFCD00063466
NSC-757862
1416768-32-5
DTXSID8045351
CHEBI:32164
U700P169W2
NCGC00016572-01
4-AMINO-N-(6-METHOXY-4-PYRIMIDINYL)-BENZENESULFONAMIDE
CAS-1220-83-3
Sulfamonomethoxine 100 microg/mL in Acetonitrile
DS-36
DTXCID6025351
DJ-1550
4-Amino-N-(6-methoxy-pyrimidin-4-yl)-benzene-13C6-sulfonamide hydrate (see Data Sheet)
ICI 32525
SMR000036718
Ro 4-3476
Sulfamonomethoxinum [INN-Latin]
Sulfamonometoxina [INN-Spanish]
SR-01000000177
BRN 0621128
Sulfamonomethoxine [USAN:INN:BAN:JAN]
4-METHOXY-6-SULFANILAMIDOPYRIMIDINE
UNII-U700P169W2
Prestwick_105
Spectrum_001414
Prestwick0_000823
Prestwick1_000823
Prestwick2_000823
Prestwick3_000823
Spectrum2_001421
Spectrum3_000913
Spectrum4_001012
Spectrum5_000985
N(sup 1)-(6-Methoxy-4-pyrimidinyl)sulfanilamide
Oprea1_147724
SCHEMBL93784
BSPBio_000745
KBioGR_001503
KBioSS_001894
Sulfamonomethoxine (Standard)
5-25-12-00493 (Beilstein Handbook Reference)
MLS000069737
MLS000079369
DivK1c_000949
SPECTRUM1501147
SPBio_001522
SPBio_002666
BPBio1_000821
CHEMBL462990
Sulfanilamide, N(sup 1)-(6-methoxy-4-pyrimidinyl)-
SULFAMONOMETHOXINE [INN]
SULFAMONOMETHOXINE [JAN]
Sulfamonomethoxine-13C6 Hydrate
GTPL12688
HMS502P11
HY-B0946R
KBio1_000949
KBio2_001894
KBio2_004462
KBio2_007030
KBio3_001886
SULFAMONOMETHOXINE [USAN]
NINDS_000949
WMPXPUYPYQKQCX-UHFFFAOYSA-N
GLXC-10378
HMS1570F07
HMS1921J21
HMS2092H07
HMS2097F07
HMS3714F07
Pharmakon1600-01501147
SULFAMONOMETHOXINE [MART.]
Ro43476
SULFAMONOMETHOXINE [WHO-DD]
HY-B0946
Sulfamonomethoxine (JAN/USAN/INN)
Tox21_110502
BBL023014
CCG-38995
NSC757862
s3644
STL089636
AKOS000308735
Tox21_110502_1
1ST4040
CS-4419
NSC 757862
IDI1_000949
NCGC00016572-02
NCGC00016572-03
NCGC00016572-04
NCGC00016572-05
NCGC00016572-06
NCGC00016572-07
NCGC00016572-08
NCGC00016572-12
NCGC00023060-04
NCGC00023060-05
AC-14922
AS-70089
DA-58176
N-(6-Methoxy-4-pyrimidinyl)sulfanilamide
SBI-0051659.P002
DB-041649
AB00052221
NS00009596
S0592
C71832
D01141
AB00052221-12
AB00052221_14
Sulfamonomethoxine 1000 microg/mL in Acetonitrile
SR-01000000177-3
SR-01000000177-4
BRD-K14116214-001-04-7
BRD-K14116214-001-07-0
BRD-K14116214-001-09-6
Q27114805
Sulfamonomethoxine, VETRANAL(TM), analytical standard
4-amino-N-(6-methoxy-pyrimidin-4-yl)-benzenesulfonamide
K4Y