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Sulfapyrazine

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Identification
Molecular formula
C10H10N4O2S
CAS number
80-36-4
IUPAC name
4-amino-N-pyrazin-2-yl-benzenesulfonamide
State
State
At room temperature, sulfapyrazine is a solid substance.
Melting point (Celsius)
188.00
Melting point (Kelvin)
461.15
Boiling point (Celsius)
457.00
Boiling point (Kelvin)
730.15
General information
Molecular weight
280.31g/mol
Molar mass
280.3080g/mol
Density
1.5900g/cm3
Appearence

Sulfapyrazine typically appears as a white to off-white crystalline powder. It is pretty much odorless and has a slightly bitter taste.

Comment on solubility

Solubility of 4-amino-N-pyrazin-2-yl-benzenesulfonamide

The solubility of 4-amino-N-pyrazin-2-yl-benzenesulfonamide is influenced by several factors that affect how this compound interacts with solvents. In general, the presence of various functional groups in the molecule can significantly dictate its solubility properties.

  • Polarity: The sulfonamide group (-SO2NH2) tends to increase the polarity of the compound, thereby enhancing its solubility in polar solvents like water.
  • Hydrogen Bonding: The ability of this compound to form hydrogen bonds with water molecules adds to its solubility, making it more soluble than non-polar analogs.
  • pH Dependency: The solubility can vary with pH; as the environment becomes more acidic or basic, the ionization of the amine and sulfonamide functionalities can change, leading to increased solubility in some cases.
  • Temperature Influence: Generally, an increase in temperature can enhance solubility for many compounds. Thus, evaluating solubility at elevated temperatures would provide more insight.

As a systemic rule, it's often found that:

"Like dissolves like."

This means that polar compounds tend to dissolve well in polar solvents, while non-polar compounds are better suited for non-polar solvents. Therefore, the solubility of 4-amino-N-pyrazin-2-yl-benzenesulfonamide in water may be relatively good due to its polar character, but experimental data would provide the most accurate perspective.

Interesting facts

Interesting Facts about 4-amino-N-pyrazin-2-yl-benzenesulfonamide

4-amino-N-pyrazin-2-yl-benzenesulfonamide is a fascinating compound with significant implications in medicinal chemistry and drug development. Here are some noteworthy aspects:

  • Pharmacological Importance: This compound has shown potential as a therapeutic agent. It is often investigated for its role in antitumor and antibacterial applications, providing a promising pathway for new drug formulations.
  • Structural Feature: The presence of the pyrazine ring enhances the compound's biological activity. Pyrazine derivatives are widely recognized for their diverse pharmacological properties and are structurally similar to many bioactive molecules.
  • Sulfonamide Group: The sulfonamide functional group is known for its broad-spectrum antimicrobial activity. This characteristic has historically made sulfonamides vital in the treatment of bacterial infections.
  • Research and Development: Scientists are keen on modifying the structure of this compound to enhance its efficacy and selectivity. Such modifications can lead to the discovery of new derivatives with improved biological activities.
  • Impact on Daily Life: Compounds like 4-amino-N-pyrazin-2-yl-benzenesulfonamide have implications not just in medicine but also in agricultural chemistry, where they may be involved in developing new agrochemicals that target plant pathogens.

As researchers delve into the specifics of 4-amino-N-pyrazin-2-yl-benzenesulfonamide, it is crucial to recognize the continuous evolution of this compound's use. The continual exploration of its properties and functions underscores the dynamic nature of chemical research, pushing boundaries in various fields.

Synonyms
SULFAPYRAZINE
116-44-9
2-Sulfanilamidopyrazine
Pyrazine, sulfanilamido-
4-Amino-N-(pyrazin-2-yl)benzenesulfonamide
N1-2-Pyrazinylsulfanilamide
Sulfanilamide, N1-(pyrazinyl)-
4-amino-N-pyrazin-2-ylbenzenesulfonamide
N(sup 1)-2-Pyrazinylsulfonilamide
4-Amino-N-pyrazinylbenzenesulfonamide
UNII-8BE3C727OG
NSC 25872
NSC 41835
Sulfanilamide, N(sup 1)-(pyrazinyl)-
BRN 0235481
8BE3C727OG
Benzenesulfonamide, 4-amino-N-pyrazinyl-
Benzenesulfonamide, 4-amino-N-2-pyrazinyl-
NSC-25872
NSC-41835
SULFAPYRAZINE [MI]
4-Amino-N-(pyrazinyl)benzenesulfonamide
DTXSID30151256
5-25-10-00140 (Beilstein Handbook Reference)
NSC25872
NSC41835
4-amino-N-(pyrazin-2-yl)benzene-1-sulfonamide
Sulfanilamidopyrazin
pyrazine, 2-sulphanilamido-
SCHEMBL152522
DTXCID5073747
4-Amino-N-pyrazinyl-benzenesulfonamide
Sulfanilamide, N1-(pyrazinyl)-(8CI)
4-amino-N-pyrazin-2-yl-benzenesulfonamide
NS00011881
Q27270142