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Sulfathiazole

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Identification
Molecular formula
C9H9N3O2S2
CAS number
72-14-0
IUPAC name
4-amino-N-thiazol-2-yl-benzenesulfonamide
State
State

At room temperature, sulfathiazole is typically found in a solid state as a powder or crystalline form.

Melting point (Celsius)
202.00
Melting point (Kelvin)
475.15
Boiling point (Celsius)
505.10
Boiling point (Kelvin)
778.25
General information
Molecular weight
255.31g/mol
Molar mass
255.3030g/mol
Density
1.5400g/cm3
Appearence

Sulfathiazole appears as an odorless, white to faintly yellowish powder. It is crystalline in nature and may have a slightly bitter taste.

Comment on solubility

Solubility of 4-amino-N-thiazol-2-yl-benzenesulfonamide

The solubility of a chemical compound is a crucial aspect that governs its applications in various fields, including pharmaceuticals and industrial processes. For 4-amino-N-thiazol-2-yl-benzenesulfonamide (C9H9N3O2S2), the solubility characteristics can be summarized as follows:

  • Solvent Dependence: The solubility of this compound may vary significantly depending on the solvent used. Common solvents include water, ethanol, and dimethyl sulfoxide (DMSO).
  • Temperature Effects: Increasing temperature generally enhances solubility for many organic compounds. Thus, 4-amino-N-thiazol-2-yl-benzenesulfonamide may exhibit higher solubility at elevated temperatures.
  • pH Influence: The ionization states of amino and sulfonamide groups could affect solubility; thus, pH adjustments might lead to enhanced solubility in certain environments.
  • Polarity Factor: The presence of polar functional groups contributes to the overall solubility but may also lead to relatively lower solubility in non-polar solvents.

In conclusion, the solubility of 4-amino-N-thiazol-2-yl-benzenesulfonamide is influenced by multiple factors such as solvent choice, temperature, pH, and polarity. Understanding these factors is essential for optimizing its use in various applications.

Interesting facts

Interesting Facts about 4-amino-N-thiazol-2-yl-benzenesulfonamide

4-amino-N-thiazol-2-yl-benzenesulfonamide, often referred to in scientific literature as a compound with significant pharmaceutical implications, is a fascinating example of how small changes in molecular structure can lead to major differences in biological activity. Here are some key insights:

  • Pharmaceutical Applications: This compound belongs to a class of molecules with potential use as antibacterial agents. Its unique structure allows it to inhibit bacterial growth, which is crucial in the development of new antibiotics.
  • Thiazole Ring Benefits: The thiazole moiety in its structure has been extensively studied for its role in medicinal chemistry. It enhances the compound's interaction with biological targets, leading to higher efficacy in treatments.
  • Dual Functionality: 4-amino-N-thiazol-2-yl-benzenesulfonamide showcases not only antibacterial properties but may also possess antivirulent characteristics. This dual functionality opens new avenues in infectious disease management.
  • Sulfonamide Derivative: As a derivative of sulfonamides, this compound contributes to the ongoing exploration of sulfa drugs, which were among the first antibiotics ever developed. The persistence of sulfonamides in modern medicine is a testament to their significance.

In summary, the exploration of compounds like 4-amino-N-thiazol-2-yl-benzenesulfonamide is critical for the future of drug development. As chemists continue to uncover the mechanisms of action and optimize structure-activity relationships, this compound could play a vital role in combating resistant strains of bacteria. "The molecular diversity in medicinal compounds opens infinite possibilities for innovation."

Synonyms
sulfathiazole
72-14-0
Sulphathiazole
Sulfathiazol
Thiazamide
Sulfanilamidothiazole
2-Sulfanilamidothiazole
Norsulfazole
Norsulfasol
2-Sulfonamidothiazole
4-Amino-N-(thiazol-2-yl)benzenesulfonamide
Neostrepsan
Sulfatiazol
Sulfocerol
Thiozamide
Sulzol
2-(Sulfanilylamino)thiazole
Formosulfathiazole
Sulfathiazolum
Azoquimiol
Azoseptale
Cerazole
Chemosept
Eleudron
Estafilol
Norsulfazol
Planomide
Poliseptil
Sanotiazol
Septozol
Thiacoccine
Thiasulfol
Wintrazole
2-Sulfanilamidothiazol
Cibazol
Duatok
Dulana
Coco-Thiazole
2-(p-Aminobenzenesulfonamido)thiazole
N(1)-2-Thiazolylsulfanilamide
Streptosilthiazole
4-Amino-N-2-thiazolylbenzenesulfonamide
Sulfamul
Usaf sn-9
Cerazol (suspension)
2-(p-Aminobenzenesulphonamido)thiazole
Norsulfazolum
Ciba 3714
N1-(2-Thiazolyl)sulfanilamide
4-Amino-N-(1,3-Thiazol-2-Yl)Benzene-1-Sulfonamide
Solfatiazolo
N1-2-Thiazolylsulfanilamide
M&B 760
Caswell No. 809B
4-Amino-N-(1,3-thiazol-2-yl)benzenesulfonamide
Benzenesulfonamide, 4-amino-N-2-thiazolyl-
Sulfanilamide, N1-2-thiazolyl-
RP 2090
N(sup 1)-2-Thiazolylsulfanilamide
2090 R.P.
CCRIS 765
sulfthiazole
CHEBI:9337
4-amino-N-1,3-thiazol-2-ylbenzenesulfonamide
2090 rp
M+B 760
UNII-Y7FKS2XWQH
Y7FKS2XWQH
HSDB 4380
2-Sulfathiazole
4-Amino-N-thiazol-2-yl-benzenesulfonamide
Sulfanilamide, N(1)-2-thiazolyl-
Sulfathiazol [INN-French]
Sulfatiazol [INN-Spanish]
EINECS 200-771-5
Sulfathiazolum [INN-Latin]
NSC 31812
NSC-31812
Triple sulfa (sulfathiazole)
EPA Pesticide Chemical Code 077903
NSC 683531
NSC-683531
Sulfanilamide, N(sup 1)-2-thiazolyl-
DTXSID8026068
AI3-01050
Sodium sulfathiazole
MFCD00005319
CHEMBL437
DTXCID606068
N'-(2-Thiazolyl)sulfanilamide
Sulfathiazole [USP:INN:BAN]
N(sup1)-(2-Thiazolyl)sulfanilamide
TRYSUL COMPONENT SULFATHIAZOLE
NSC683531
Sulfanilamide, N(sup1)-2-thiazolyl-
SULTRIN COMPONENT SULFATHIAZOLE
VAGILIA COMPONENT SULFATHIAZOLE
CAS-72-14-0
GYNE-SULF COMPONENT SULFATHIAZOLE
NCGC00016309-02
NCGC00016309-06
4-Amino-N-(2-thiazolyl)benzenesulfonamide
Sulfanilamide, N1-4-thiazolin-2-ylidene-
Sulfathiazole 100 microg/mL in Acetonitrile
Sulfathiazol (INN-French)
Sulfatiazol (INN-Spanish)
Sulfathiazolum (INN-Latin)
SULFATHIAZOLE (MART.)
SULFATHIAZOLE [MART.]
SULFATHIAZOLE (USP-RS)
SULFATHIAZOLE [USP-RS]
Sulfathiazole (USP:INN:BAN)
Solfatiazolo [DCIT]
SULFATHIAZOLE (EP MONOGRAPH)
SULFATHIAZOLE [EP MONOGRAPH]
SULFATHIAZOLE (USP MONOGRAPH)
SULFATHIAZOLE [USP MONOGRAPH]
2-Sulfanilamidothiazol [German]
SR-05000001722
sulfatiazolo
Sulfathiazole; 4-Amino-N-(thiazol-2-yl)benzenesulfonamide
Enterobiocine
Sulfavitina
Cerazol
Sulfaplex
YTZ
Prestwick_430
Spectrum_001000
4-amino-N-2-thiazolyl Benzenesulfonamide
Benzenesulfonamide, 4 amino N 2 thiazolyl
Benzenesulfonamide, 4-amino-N-2-thiazolyl
Sulfathiazole (Standard)
Prestwick0_000016
Prestwick1_000016
Prestwick2_000016
Prestwick3_000016
Spectrum2_000841
Spectrum3_001729
Spectrum4_000348
Spectrum5_001441
Sulfathiazole (USP/INN)
N-2-Thiazolylsulfanilamide
SULFATHIAZOLE [MI]
Epitope ID:122234
SULFATHIAZOLE [INN]
Cambridge id 5251400
cid_5340
SULFATHIAZOLE [HSDB]
Oprea1_105970
Oprea1_297844
SCHEMBL94165
BSPBio_000051
BSPBio_003378
KBioGR_000755
KBioSS_001480
SULFATHIAZOLE [VANDF]
[(4-Aminophenyl)sulfonyl]-1,3-thiazol-2-ylamine
MLS002154174
N-1-2-Thiazolylsulfanilamide
DivK1c_000560
SPECTRUM1500553
SPBio_000821
SPBio_001972
SULFATHIAZOLE [WHO-DD]
BPBio1_000057
WLN: T5N CSJ BMSWR DZ
GTPL12699
HMS501L22
HY-B0507R
KBio1_000560
KBio2_001480
KBio2_004048
KBio2_006616
KBio3_002598
D06BA02
J01EB07
N(sup1)-2-Thiazolylsulfanilamide
NINDS_000560
HMS1568C13
HMS1921C07
HMS2092K09
HMS2095C13
HMS2259A13
HMS3652A03
HMS3712C13
Pharmakon1600-01500553
SULFATHIAZOLE [GREEN BOOK]
SULFATHIAZOLE [ORANGE BOOK]
HY-B0507
NSC31812
SULFATHIAZOLE (TRIPLE SULFA)
Tox21_110363
Tox21_202243
Tox21_303238
BDBM50027796
CCG-40296
NSC757331
s3116
STK043870
2-(4-Aminobenzenesulfonamido)thiazole
AKOS000108630
Tox21_110363_1
DB06147
FS27944
NSC-757331
SDCCGMLS-0065585.P001
IDI1_000560
N(SUP1)-2-THIAZOYLSULFANILAMIDE
SULFATHIAZOLE COMPONENT OF TRYSUL
NCGC00016309-01
NCGC00016309-03
NCGC00016309-04
NCGC00016309-05
NCGC00016309-07
NCGC00016309-08
NCGC00016309-09
NCGC00016309-10
NCGC00016309-14
NCGC00091133-01
NCGC00091133-02
NCGC00091133-03
NCGC00091133-04
NCGC00257187-01
NCGC00259792-01
SULFATHIAZOLE COMPONENT OF SULTRIN
SULFATHIAZOLE COMPONENT OF VAGILIA
AC-12783
DS-17245
NCI60_002730
SMR000017368
Pyridine,2-(chloromethyl)-3,4-dimethoxy-
SBI-0051527.P004
thiazole, 2-(p-amino)benzenesulphonamido-
DB-055610
SULFATHIAZOLE COMPONENT OF GYNE-SULF
4-amino-N-(thiazol-2-yl)-benzenesulfonamide
AB00052102
N-(2-Thiazolyl)benzenesulfonamide, 4-amino-
NS00000201
SW149625-4
4-[(1,3-Thiazol-2-yl)aminosulfonyl]aniline
EN300-18132
Sulfathiazole 1000 microg/mL in Acetonitrile
Sulfathiazole, analytical standard, >=98.0%
D01047
D70411
AB00052102_14
AB00052102_15
Q408427
Sulfathiazole, VETRANAL(TM), analytical standard
TRIPLE SULFA (SULFATHIAZOLE) [ORANGE BOOK]
4-Amino-N-(1,3-thiazol-2-yl)benzenesulfonamide #
SR-05000001722-1
SR-05000001722-3
BRD-K14705039-001-05-7
BRD-K14705039-001-08-1
BRD-K14705039-001-15-6
BRD-K14705039-001-16-4
Z57198680
F1443-4816
Sulfathiazole, European Pharmacopoeia (EP) Reference Standard
Sulfathiazole, United States Pharmacopeia (USP) Reference Standard
200-771-5