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4-Aminomethylcyclohexylmethanamine

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Identification
Molecular formula
C8H18N2
CAS number
1476-34-6
IUPAC name
[4-(aminomethyl)cyclohexyl]methanamine
State
State

This compound is typically found as a liquid at room temperature.

Melting point (Celsius)
16.40
Melting point (Kelvin)
289.55
Boiling point (Celsius)
203.00
Boiling point (Kelvin)
476.15
General information
Molecular weight
128.22g/mol
Molar mass
128.2150g/mol
Density
0.9550g/cm3
Appearence

4-Aminomethylcyclohexylmethanamine is typically seen as a colorless to pale yellow liquid with a fishy or ammonia-like odor. It's crucial to handle it with care as it can be irritating to the skin and eyes.

Comment on solubility

Solubility of [4-(aminomethyl)cyclohexyl]methanamine

The solubility characteristics of [4-(aminomethyl)cyclohexyl]methanamine, a compound with both amine and cyclohexyl functional groups, can be quite intriguing. This compound displays notable solubility in a variety of solvents due to its functional groups which allow for hydrogen bonding and dipole interactions. Below are some important points regarding its solubility:

  • Aqueous Solubility: Generally, amines are known to be soluble in water owing to their ability to form hydrogen bonds. [4-(aminomethyl)cyclohexyl]methanamine may exhibit good solubility in aqueous solutions.
  • Organic Solvents: The compound is likely soluble in many organic solvents such as ethanol, methanol, and DMSO, owing to the presence of the cyclohexyl group which increases the hydrophobic character while still allowing for solvation through the amine group.
  • Solubility Trends: As with other amines, the solubility might depend on the pH of the solution; at lower pH values, the amine can become protonated, potentially increasing its solubility in aqueous solutions.

Overall, the solubility of [4-(aminomethyl)cyclohexyl]methanamine showcases its versatility in both polar and nonpolar environments. Its ability to engage in multiple types of intermolecular interactions enhances its solubility profile, making it a compound of interest in various applications.

Interesting facts

Interesting Facts about [4-(aminomethyl)cyclohexyl]methanamine

[4-(aminomethyl)cyclohexyl]methanamine, commonly referred to in scientific literature as a specialized amine compound, is of particular interest due to its versatile applications in various fields of research.

Key Characteristics and Applications:

  • Pharmaceutical Applications: This compound is often studied for its potential role as a building block in the synthesis of various pharmaceuticals, particularly those aimed at treating neurological disorders.
  • Research in Material Science: It is utilized in developing novel polymers and other materials due to its functional amine groups, which can facilitate chemical bonding and cross-linking.
  • Involvement in Organic Synthesis: Scientists appreciate its utility in organic synthesis, particularly reactions involving nucleophilic substitutions.

Some Scientific Insights:

One of the notable features of [4-(aminomethyl)cyclohexyl]methanamine is that it features a cyclohexyl group, which contributes to its distinct chemical reactivity and steric properties. As an amine, it can act as a proton acceptor in various chemical reactions, making it a useful reagent in organic chemistry.

As stated in a recent study, "The incorporation of cyclohexyl structures into amine compounds can enhance their therapeutic efficacy by improving their lipophilicity." This highlights its importance in medicinal chemistry.

Safety Considerations:

While exploring compounds like [4-(aminomethyl)cyclohexyl]methanamine, it is imperative to observe strict safety protocols due to the potential hazards associated with amines. Proper protective equipment and ventilation should always be utilized in laboratory settings.

In conclusion, [4-(aminomethyl)cyclohexyl]methanamine stands out as a fascinating compound not only for its diverse applications but also for its significance in advancing research in pharmaceuticals and material science.

Synonyms
2549-93-1
cis-1,4-Bis(aminomethyl)cyclohexane
1,4-Bis(aminomethyl)cyclohexane
trans-1,4-Bis(aminomethyl)cyclohexane
1,4-Cyclohexanedimethanamine
Bamch
Cyclohex-1,4-ylenebis(methylamine)
EINECS 219-840-6
AI3-26964
CYCLOHEXANE, 1,4-BIS(AMINOMETHYL)-
DTXSID4062511
DTXCID5037311
219-840-6
805-776-1
805-777-7
10029-07-9
10029-09-1
1,4-Cyclohexanebis(methylamine)
Cyclohexane-1,4-diyldimethanamine
[4-(aminomethyl)cyclohexyl]methanamine
1,4-Cyclohexanedimethanamine, cis-
trans-1,4-cyclohexanedimethanamine
Hexahydro-p-xylylenediamine
1,4-Di(aminomethyl)cyclohexane
cis-1,4-Cyclohexanedimethanamine
cis-1,4-Cyclohexanebis(methylamine)
1,4-Cyclohexanedimethanamine, trans-
trans-1,4-Cyclohexanebis(methylamine)
1-[(1R,4R)-4-(AMINOMETHYL)CYCLOHEXYL]METHANAMINE
1-[(1S,4S)-4-(AMINOMETHYL)CYCLOHEXYL]METHANAMINE
1-[4-(aminomethyl)cyclohexyl]methanamine
MFCD00039463
MFCD20037427
MFCD20617651
[4-(Aminomethyl)cyclohexyl]methylamine
1alpha,4beta-Cyclohexanebis(methanamine)
1alpha,4alpha-Cyclohexanebis(methanamine)
1,4-Cyclohexanedimethylamine
SCHEMBL48375
1,4-bisaminomethlycyclohexane
p-Bis(aminomethyl)cyclohexane
SCHEMBL432248
1,4-bis-aminomethylcyclohexane
cis-Hexahydro-p-xylylenediamine
SCHEMBL1703765
trans-Hexahydro-p-xylylenediamine
1,4-cyclohexane-bis(methylamine)
1.4-Cyclohexane-bis(methylamine)
OXIKYYJDTWKERT-OCAPTIKFSA-N
1,4-Cyclohexylenebis(methylamine)
DTXSID101298049
DTXSID501302155
1,4-bis-(aminomethyl)-cyclohexane
cis-1,4-Di(aminomethyl)cyclohexane
KAA02909
NSC71995
NSC71997
4-Aminomethyl-cyclohexylmethyl-amine
NSC-71995
NSC-71997
1,4-Cyclohexanedimethylamine, trans-
cis-4-Aminomethylcyclohexylmethylamine
trans-1,4-Di(aminomethyl)cyclohexane
AKOS006342381
AKOS006342382
AKOS009158487
cis-1,4-Cyclohexylenebis(methylamine)
1,4-Cyclohexanebis(methylamine), cis-
SB30037
SB30038
trans-1, 4cyclohexane-bis(methylamine)
1,4-Cyclohexanebis(methylamine), trans-
[4-(Aminomethyl)cyclohexyl]methylamine #
BP-13457
BP-30062
BS-27717
BS-43837
Cyclohexane-1alpha,4beta-bis(methanamine)
Cyclohexane-1alpha,4beta-di(methaneamine)
Cyclohexane-1alpha,4alpha-bis(methanamine)
DB-046713
DB-058342
DB-264643
B1083
B5146
B5147
CS-0128816
CS-0439581
CS-0439605
NS00019888
[4-(Aminomethyl)cyclohexyl]methylamine, trans
1,4-Cyclohexanebis(methylamine), cis + trans
((1R,4r)-cyclohexane-1,4-diyl)dimethanamine
((1S,4s)-cyclohexane-1,4-diyl)dimethanamine
[4-(Aminomethyl)cyclohexyl]methylamine, (Z)-
F14924
T70001
T70002
[(1r,4r)-4-(aminomethyl)cyclohexyl]methanamine
EN300-2994142