Skip to main content

(4-aminophenyl)sulfonylurea

ADVERTISEMENT
Identification
Molecular formula
C7H9N3O3S
CAS number
2626-38-0
IUPAC name
(4-aminophenyl)sulfonylurea
State
State

At room temperature, (4-aminophenyl)sulfonylurea is a solid. It is often utilized in the chemical industry as a stable solid compound with applications across various chemical synthesis processes.

Melting point (Celsius)
156.00
Melting point (Kelvin)
429.15
Boiling point (Celsius)
337.90
Boiling point (Kelvin)
611.05
General information
Molecular weight
215.23g/mol
Molar mass
215.2440g/mol
Density
1.3846g/cm3
Appearence

(4-Aminophenyl)sulfonylurea appears as a white crystalline solid. It is a compound characterized by its solid structure at room temperature, and its crystallinity can be noted in its purified form.

Comment on solubility

Solubility of (4-aminophenyl)sulfonylurea

The solubility of (4-aminophenyl)sulfonylurea can vary significantly based on environmental conditions and solvent characteristics. Understanding its solubility profile is essential for various applications, especially in pharmacology and industrial contexts. Here are some key points to consider:

  • Polar Solvents: (4-aminophenyl)sulfonylurea tends to be soluble in polar solvents such as water and methanol due to the presence of amino and sulfonyl functional groups.
  • Non-Polar Solvents: Conversely, it shows limited solubility in non-polar solvents, which can hinder its application in certain contexts.
  • Temperature Effect: Solubility generally increases with temperature—higher temperatures may enhance the dissolution of this compound in various solvents.
  • pH Influence: The solubility may also be pH-dependent, with enhanced solubility observed in slightly acidic to neutral solutions.

As a result, it is crucial to evaluate the specific conditions under which (4-aminophenyl)sulfonylurea is utilized to maximize its effectiveness and ensure appropriate concentrations within solutions. Furthermore, understanding the solubility behavior can aid in predicting reactivity and stability in various environments.

Interesting facts

Interesting Facts about (4-aminophenyl)sulfonylurea

(4-aminophenyl)sulfonylurea is a fascinating compound that bridges the realms of organic chemistry and pharmaceuticals. As a member of the sulfonylurea class, it plays a significant role in the management of type 2 diabetes. Here are some intriguing aspects of this compound:

  • Mechanism of Action: (4-aminophenyl)sulfonylurea functions by stimulating insulin secretion from pancreatic β-cells. This action helps to lower blood glucose levels, making it crucial for patients with insulin resistance.
  • Role in Drug Development: This compound has been foundational in the development of various antidiabetic drugs. Its derivatives often lead to more efficient medications that improve patients' quality of life.
  • Synthetic Pathways: Chemists employ various methods to synthesize (4-aminophenyl)sulfonylurea, often involving nucleophilic substitution and sulfonylation reactions. These reactions are an excellent demonstration of how structure and stability can be manipulated in organic compounds.
  • Research Potential: Beyond its use in diabetes management, ongoing research is exploring the potential anti-cancer properties of sulfonylureas, including (4-aminophenyl)sulfonylurea. Some studies suggest that compounds in this class may have the ability to induce apoptosis in certain cancer cells, opening new avenues for cancer therapy.
  • Global Impact: With the rising prevalence of diabetes globally, compounds like (4-aminophenyl)sulfonylurea are pivotal in public health. They help to alleviate not only individual suffering but also reduce the burden on healthcare systems by managing chronic illnesses effectively.

In conclusion, the study of (4-aminophenyl)sulfonylurea underlines the importance of chemical compounds in medicinal chemistry and their significant impact on human health.

Synonyms
Sulfacarbamide
547-44-4
SULFANILYLUREA
Sulfaurea
Urosulfan
Sulphaurea
Euvernil
Uractyl
Uramid
Urenil
Sulfanilcarbamid
Sulfanyluree
Urosulfane
Sulfanylharnstoff
4-Sulfacarbamide
1-(4-Aminobenzenesulfonyl)urea
N-Sulfanilcarbamide
Sulfanilcarbamide
p-Aminobenzenesulfonylurea
Urea, sulfanilyl-
Solfacarbamide
Sulfacarbamida
Sulfacarbamidum
Urosulphanum
Sulfaurea (VAN)
N-sulfanilylcarbamide
Solfacarbamide [DCIT]
1-Sulfanilylurea
4-Amino-N-(aminocarbonyl)benzenesulfonamide
Sulfanilamide, N(sup1)-carbamoyl-
Sulfacarbamidum [INN-Latin]
Sulfacarbamida [INN-Spanish]
NSC 78438
UNII-W6CD25Z4QR
EINECS 208-922-7
NSC-78438
BRN 2118358
Sulfacarbamide [INN:BAN:DCF]
DTXSID1046425
K 7617
SULFANILYLUREA [MI]
SULFACARBAMIDE [INN]
Sulfanilamide, N1-carbamoyl-
SULFACARBAMIDE [MART.]
SULFACARBAMIDE [WHO-DD]
DTXCID9026425
Sulfacarbamidum (INN-Latin)
Sulfacarbamida (INN-Spanish)
SULFACARBAMIDE (MART.)
uromide
208-922-7
4-14-00-02667 (beilstein handbook reference)
wvakabmnnsmcdk-uhfffaoysa-n
4-Amino-N-carbamoylbenzenesulfonamide
(4-aminophenyl)sulfonylurea
Benzenesulfonamide, 4-amino-N-(aminocarbonyl)-
(4-aminobenzenesulfonyl)urea
A 435
W6CD25Z4QR
Sulfacarbamide-d4
NSC78438
NCGC00164541-01
N-[(4-Aminophenyl)sulphonyl]urea (Sulphacarbamide)
Benzenesulfonamide, 4-amino-N-(aminocarbonyl)- (9CI)
CAS-547-44-4
A 435 (VAN)
Sulfacarbamid
1-amino-4-{[(aminocarbonyl)amino]sulfonyl}benzene
N-[(4-Aminophenyl)sulphonyl]urea; Sulfaguanidine Imp. B (EP); Sulphacarbamide; Sulfaguanidine Impurity B
aniline, 4-ureidosulphonyl-
TimTec1_001606
Oprea1_259031
Oprea1_401262
SCHEMBL154846
CHEMBL139877
CHEBI:134891
HMS3264E15
Pharmakon1600-01506107
AAA54744
ALBB-035555
HY-B1236
Tox21_112170
MFCD00025437
NSC760438
STL479060
AKOS001590379
Tox21_112170_1
CCG-103786
CS-4882
NSC-760438
NCGC00164541-02
NCGC00164541-03
AS-56531
DB-007877
4-Amino-N-(aminocarbonyl)-benzenesulfonamide
NS00003116
D82075
EN300-114388
AB01563222_01
SR-01000944240
SR-01000944240-1
1-Amino-4-([(aminocarbonyl)amino]sulfonyl)benzene #
BRD-K13486660-001-01-0
Q27292394
Z276118944