Nofetumomab | Solubility of Things

Identification

Molecular formula

C₁₈H₁₅N₃O₄S

CAS number

129802-50-4

IUPAC name

4-anilino-3-nitro-N-phenyl-benzenesulfonamide

State

In its standard state at room temperature, Nofetumomab is a solid.

Melting point (Celsius)

0.00

Melting point (Kelvin)

273.15

Boiling point (Celsius)

0.00

Boiling point (Kelvin)

273.15

General information

Molecular weight

418.46g/mol

Molar mass

418.4570g/mol

Density

1.4350g/cm³

Appearence

Nofetumomab is typically found as a white to off-white powder.

Comment on solubility

Solubility of 4-anilino-3-nitro-N-phenyl-benzenesulfonamide

When discussing the solubility of 4-anilino-3-nitro-N-phenyl-benzenesulfonamide, several important factors come into play. This compound exhibits a unique combination of properties derived from its structural components, which significantly influence its solubility in various solvents.

Factors Affecting Solubility

Molecular Structure: The presence of both anilino and sulfonamide groups plays a pivotal role in solubility. The sulfonamide (-SO₂NH₂) group is known to enhance solubility in polar solvents due to its ionic character.
Polarity: The overall polarity of the molecule affects how it interacts with solvents. The nitro (-NO₂) and sulfonamide groups increase the polarity, which generally leads to better solubility in polar solvents like water.
Hydrogen Bonding: The ability of the compound to form hydrogen bonds with solvent molecules may enhance its solubility. The amino group can act as a donor and acceptor for hydrogen bonding, further affecting the solubility characteristics.

Solvent Compatibility

In terms of practical solubility:

It tends to be more soluble in polar solvents such as water, alcohols, or dimethyl sulfoxide (DMSO).
In contrast, its solubility in non-polar solvents is expected to be significantly lower, limiting its use in certain applications.

In conclusion, the solubility of 4-anilino-3-nitro-N-phenyl-benzenesulfonamide is influenced by its molecular structure, polarity, and ability to engage in hydrogen bonding. This compound is likely to exhibit favorable solubility in polar environments, making it suitable for various chemical applications where solvation is a key factor.

Interesting facts

Interesting Facts about 4-anilino-3-nitro-N-phenyl-benzenesulfonamide

4-anilino-3-nitro-N-phenyl-benzenesulfonamide is a fascinating compound with noteworthy chemical properties and applications. It belongs to the class of sulfonamides, which are characterized by their sulfonyl group attached to an amino group. Here are some intriguing aspects of this compound:

Pharmaceutical Relevance: This compound exhibits potential biological activity, making it of interest in medicinal chemistry. Its structure suggests that it may interact with various biochemical pathways, indicating possible pharmaceutical applications.
Structure Diversity: The combination of aniline and nitro groups in its structure grants this compound unique reactivity and potential for further chemical modifications, allowing scientists to tailor its properties for specific applications.
Colorimetric Properties: Compounds such as 4-anilino-3-nitro-N-phenyl-benzenesulfonamide can have colorimetric uses, enabling their application in colorimetric analysis techniques in analytical chemistry.
Versatile Intermediates: The sulfonamide moiety can act as a versatile intermediate in organic synthesis, facilitating the preparation of a wide range of other chemical compounds.
Research Interest: Researchers are continuously studying this compound to explore its effectiveness against various targets, including bacteria and cancer cells, due to the nitro group known for its electron-withdrawing properties, which can influence biological activity.

In conclusion, 4-anilino-3-nitro-N-phenyl-benzenesulfonamide stands as a compound of significant interest for scientists seeking new avenues in drug development and organic synthesis. Its unique properties and potential applications make it a valuable subject for ongoing research.

Synonyms

Disperse Yellow 42

Setacyl Yellow FL

C.I. Disperse Yellow 42

Latyl Yellow YL

Lenra Yellow CW

Amacel Yellow CW

Dianix Yellow YL

Benzenesulfonamide, 3-nitro-N-phenyl-4-(phenylamino)-

Amacron Yellow LS

Artisil Yellow FL

Palanil Yellow GE

Kayalon Fast Yellow YL

Cibacet Yellow GWL

Cibacet Yellow GWN

Terasil Yellow GWL

Foron Yellow SE-FL

Setacyl Yellow P-FL

Belacyl Fast Yellow W

C.I. Disperse Yellow 37

Amacel Yellow LS

Miketon Fast Yellow YL

Tertranese Yellow P-GL

Dispersol Fast Yellow T

Tersetile Yellow GL

Disperse Yellow GWL

Bellechem Estracyl Yellow W

Dispersol Yellow C-T

Diacelliton Fast Yellow YLP

Ostacet Yellow SE-LG

Celliton Fast Yellow GGLL-CF

Interchem Yellow GSF (HDLF)

4-Anilino-3-nitrobenzenesulfonanilide

3-Nitro-N-phenyl-4-(phenylamino)benzenesulfonamide

C.I. 10338

Esteroquinone Light Yellow 3JLL

Tulasteron Fast Yellow G-C

Interchem Acetate Yellow GSF

Sulfanilanilide, 3-nitro-N4-phenyl-

3-Nitro-N4-phenylsulfanilanilide

EINECS 225-862-7

XFL4U655CN

4-Anilino-3-nitro-N-phenylbenzenesulphonamide

NSC 93815

BRN 2907000

AI3-28269

NSC-93815

EC 225-862-7

0-14-00-00709 (Beilstein Handbook Reference)

Sulfanilanilide, 3-nitro-N4-phenyl-(8CI)

Sulfanilanilide, 3-nitro-N(sup 4)-phenyl-(7CI,8CI)

5124-25-4

4-anilino-3-nitro-N-phenylbenzenesulfonamide

Disperse Yellow Se-Fl

MLS002695213

C.I.Disperse Yellow 42

UNII-XFL4U655CN

SCHEMBL7115658

CHEMBL1708990

DTXSID8052148

HMS3087E07

HY-D0381

NSC93815

MFCD00056100

STK362936

AKOS000592799

Sulfanilanilide, 3-nitro-4-N-phenyl-

AS-17186

SMR001561123

Interchem Acetate Yellow GSF (HDLF-40)

DB-285489

Sulfanilanilide, 3-nitro-N(sup 4)-phenyl-

CS-0010384

NS00006007

SR-01000398627

SR-01000398627-1

F0020-1746