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Capsazepine

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Identification
Molecular formula
C18H27ClN4O2
CAS number
138977-28-3
IUPAC name
(4-azaniumylpiperazin-1-yl)ammonium;3-(4-chlorophenyl)prop-2-enoate
State
State

At room temperature, capsazepine is in solid form, contributing to its stability and usability in various chemical experiments.

Melting point (Celsius)
148.50
Melting point (Kelvin)
421.60
Boiling point (Celsius)
555.30
Boiling point (Kelvin)
828.50
General information
Molecular weight
388.89g/mol
Molar mass
388.9100g/mol
Density
1.2665g/cm3
Appearence

Capsazepine is a white crystalline solid that is often used in laboratory settings. It is typically supplied as a powder or in crystalline form.

Comment on solubility

Solubility of (4-azaniumylpiperazin-1-yl)ammonium; 3-(4-chlorophenyl)prop-2-enoate

The solubility of the compound (4-azaniumylpiperazin-1-yl)ammonium; 3-(4-chlorophenyl)prop-2-enoate can be influenced by several factors, showcasing its complex nature. This compound consists of both a piperazine derivative and a modified acrylic acid ester, which contribute to its interactions with solvents.

Factors Affecting Solubility:

  • Polarity: The presence of polar groups, such as the ammonium and chlorophenyl moieties, typically increases solubility in polar solvents, particularly water.
  • Hydrogen Bonding: The ability of the compound to engage in hydrogen bonding plays a significant role, enhancing its solubility in aqueous solutions.
  • Temperature: Higher temperatures often increase solubility for many organic compounds, including derivatives similar to this one.

Moreover, it is essential to consider that:

  • Compounds containing ammonium can be soluble in water due to their ionic nature.
  • Conversely, the aromatic nature of the chlorophenyl group may create some hydrophobic character, potentially limiting solubility in non-polar solvents.

In general, one could expect this compound to exhibit moderate solubility in aqueous environments while being less soluble in non-polar solvents. Understanding these nuances can provide deeper insights into the practical applications and behavior of this chemical entity in various formulations and reactions.

Interesting facts

Interesting Facts about (4-azaniumylpiperazin-1-yl)ammonium;3-(4-chlorophenyl)prop-2-enoate

This fascinating compound, often referred to by its common name, presents an intriguing blend of chemical properties that make it significant in various fields, particularly in medicinal chemistry. Here are some important aspects to consider:

  • Diverse Applications: This compound is particularly noted for its potential use in the development of pharmaceutical agents. Its structural components suggest interactions that could lead to therapeutic effects.
  • Multi-functional Groups: The presence of both the piperazine moiety and the chloro-substituted phenyl group provides unique reactivity patterns, enhancing its utility in organic synthesis.
  • Cationic Nature: The (4-azaniumylpiperazin-1-yl) structure indicates a positive charge under physiological conditions, which can be advantageous for creating interactions with negatively charged biological membranes.
  • Potential for Modification: The compound’s structure allows for various modifications to improve its efficacy, bioavailability, and selectivity against target biological sites.
  • Historical Context: Compounds with similar structures have been studied for decades, leading to advancements in understanding their mechanisms and optimizations in drug design.

In the words of a prominent chemist, "The beauty of chemistry lies in the relationships formed by molecular structures and their resulting functionalities." Thus, the compound's intricate characteristics embody this principle by showcasing how subtle changes in chemical structure can yield significant differences in biological activity.


In summary, the exploration of (4-azaniumylpiperazin-1-yl)ammonium;3-(4-chlorophenyl)prop-2-enoate not only enhances our understanding of chemical interactions but also paves the way for innovative therapeutic strategies.