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4-(Azetidin-3-yl)benzonitrile

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Identification
Molecular formula
C10H10N2
CAS number
675116-12-8
IUPAC name
4-(azetidin-3-yl)benzonitrile
State
State

At room temperature, 4-(Azetidin-3-yl)benzonitrile is solid. Its state can vary slightly based on the specific ambient conditions such as temperature and pressure but is predominantly found in solid form under standard lab conditions.

Melting point (Celsius)
124.60
Melting point (Kelvin)
397.80
Boiling point (Celsius)
365.40
Boiling point (Kelvin)
638.50
General information
Molecular weight
158.20g/mol
Molar mass
158.1990g/mol
Density
1.1840g/cm3
Appearence

4-(Azetidin-3-yl)benzonitrile typically appears as a solid substance. Being a substituted benzonitrile, it often forms crystalline structures depending on the specific conditions of synthesis and recrystallization if required.

Comment on solubility

Solubility of 4-(azetidin-3-yl)benzonitrile

The solubility of 4-(azetidin-3-yl)benzonitrile is influenced by various factors, primarily due to its molecular structure and functional groups. This compound exhibits specific properties that dictate its interaction with solvents. Here are some key points to consider:

  • Polarity: The presence of the benzonitrile group introduces a certain degree of polarity to the molecule, potentially allowing for solubility in polar solvents.
  • Hydrogen Bonding: The azetidine ring may engage in hydrogen bonding, which can enhance solubility in certain protic solvents.
  • Solvent Compatibility: Generally, 4-(azetidin-3-yl)benzonitrile is likely to be more soluble in organic solvents such as ethanol, methanol, and dimethyl sulfoxide than in water.

In summary, while 4-(azetidin-3-yl)benzonitrile is expected to have limited water solubility, it may dissolve effectively in a variety of organic solvents. The versatility of its solubility profile can be exploited in various chemical applications, emphasizing the importance of solvent selection in organic synthesis.

Interesting facts

Exploring 4-(azetidin-3-yl)benzonitrile

4-(azetidin-3-yl)benzonitrile is a fascinating compound that sits at the intersection of medicinal chemistry and synthetic organic chemistry. This compound is particularly notable for its potential applications in drug development, emphasizing the importance of creating molecules that can interact effectively with biological targets. Here are some compelling facts about this intriguing chemical:

  • Structural Significance: The presence of the azetidine ring, a four-membered nitrogen-containing heterocycle, enhances the compound's reactivity and biological activity.
  • Biological Potential: Compounds like 4-(azetidin-3-yl)benzonitrile have been studied for their role in developing therapies for various diseases, particularly in neuroscience and oncology.
  • Pharmacophore Features: The combination of the azetidine structure with the benzonitrile moiety creates a unique pharmacophore that interacts with protein targets, enhancing its potential as a lead compound.
  • Research Interest: This compound draws attention from chemists not only for its potential therapeutic uses but also for the intricate synthetic pathways required to produce it, making it a valuable project for students and researchers alike.

A quote that captures the essence of synthetic organic chemistry is, "Every molecule tells a story." In the case of 4-(azetidin-3-yl)benzonitrile, this story is one of innovation and the quest for new pharmacological solutions. As researchers continue to explore its mechanisms of action and applications, the compound stands as a testament to the evolving landscape of medicinal chemistry.

Ultimately, 4-(azetidin-3-yl)benzonitrile exemplifies the dynamic nature of chemical research, inspiring ongoing curiosity and exploration in the quest for new and effective therapeutic agents.

Synonyms
7215-03-4
p-(3-Azetidinyl)benzonitrile
BENZONITRILE, p-(3-AZETIDINYL)-
L 2424
BRN 0473497
DTXSID50222472
5-22-02-00425 (Beilstein Handbook Reference)
DTXCID50144963
4-(azetidin-3-yl)benzonitrile
MFCD01662140
SCHEMBL2300047
GS0577
AKOS027323180
SB50928
AS-42605
DA-22732
CS-0226515
EN300-1869070