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N-Benzoylsalicylic acid

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Identification
Molecular formula
C14H11NO4
CAS number
3287-18-9
IUPAC name
4-benzamido-2-hydroxy-benzoic acid
State
State
N-Benzoylsalicylic acid is a solid at room temperature, generally found in a powdery form.
Melting point (Celsius)
213.00
Melting point (Kelvin)
486.15
Boiling point (Celsius)
435.00
Boiling point (Kelvin)
708.15
General information
Molecular weight
255.24g/mol
Molar mass
255.2340g/mol
Density
1.4639g/cm3
Appearence

N-Benzoylsalicylic acid typically appears as a white to light yellow solid. It comes in the form of a crystalline powder that is odorless and possesses a characteristic crystalline texture.

Comment on solubility

Solubility of 4-benzamido-2-hydroxy-benzoic acid

4-benzamido-2-hydroxy-benzoic acid, also known as benzoic acid derivative, exhibits intriguing solubility characteristics that are worth noting:

  • Water Solubility: This compound demonstrates moderate solubility in water. The presence of the hydroxyl group enhances its interactions with water molecules, allowing some degree of solvation.
  • Solubility in Organic Solvents: It is generally more soluble in organic solvents like ethanol and methanol, which can effectively solvate its structure due to the non-polar benzamide moiety.
  • Temperature Dependency: The solubility can vary significantly with temperature; it typically increases as you raise the temperature.
  • pH Influence: The solubility of 4-benzamido-2-hydroxy-benzoic acid can be significantly affected by the pH of the solution. In more acidic conditions, the compound remains predominantly in its non-ionized state, whereas alkaline conditions can increase ionization, leading to enhanced water solubility.

In summary, while the solubility of 4-benzamido-2-hydroxy-benzoic acid may not be overwhelmingly high, its behavior across various solvents and conditions provides valuable insight into its chemical nature.

Interesting facts

Interesting Facts about 4-benzamido-2-hydroxy-benzoic acid

4-benzamido-2-hydroxy-benzoic acid, also known as salicylic acid amide, is a fascinating compound in the world of organic chemistry. Here are some key insights about this intriguing substance:

  • Medical Applications: This compound is often explored for its potential use in pharmaceutical formulations, particularly in the treatment of skin conditions such as psoriasis and acne due to its anti-inflammatory properties.
  • Role in Organic Synthesis: It serves as a versatile intermediate in organic synthesis, helping create more complex molecules and aiding in research development.
  • Structural Features: The presence of both amide and hydroxyl functional groups contributes to its unique chemical behavior, including the ability to form hydrogen bonds, which can influence its reactivity and solubility.
  • Natural Occurrence: Compounds related to 4-benzamido-2-hydroxy-benzoic acid can be found in various natural sources, making it of interest in the study of natural products.
  • Potential for Research: Ongoing studies are investigating the compound's effectiveness as an anti-cancer agent, which highlights the continuous relevance of chemical research in finding therapeutic agents.

In the words of renowned chemists, "Chemistry is not about a specific molecule but about the connections and transformations it can contribute towards." 4-benzamido-2-hydroxy-benzoic acid exemplifies this philosophy as it acts as a bridge in various complex reactions, showcasing the limitless possibilities within chemical research.

As a student of chemistry or a seasoned scientist, understanding such compounds enriches your perspective on the intricate web of interactions that define the field of organic chemistry.

Synonyms
Benzoylpas
13898-58-3
4-benzamido-2-hydroxybenzoic acid
benzamidosalicylate
4-(Benzoylamino)-2-hydroxybenzoic acid
Benzoic acid, 4-(benzoylamino)-2-hydroxy-
4-Benzamidosalicylic acid
NSC-159686
NSC-759125
MLS000756301
NSC 159686;Benzoyl-PAS
DTXSID8046406
XEE879L727
NCGC00164513-01
NCGC00164513-02
DTXCID6026406
SMR000528672
CAS-13898-58-3
SR-01000248152
Salicylic acid, 4-benzamido-
UNII-XEE879L727
calcium 4-benzamido-2-hydroxybenzoate
BENZOYLPAS [MI]
Cambridge id 6986823
4-BENZAMIDOSALICYLATE
Oprea1_174915
Benzoyl-p-aminosalicylic acid
N-Benzoyl-p-aminosalicylsaure
MLS000876792
SCHEMBL563122
CHEMBL1487804
NSC 159686; Benzoyl-PAS
CHEBI:135059
HMS2093H15
HMS2853C11
Pharmakon1600-01505413
4-benzamido-2-hydroxy-benzoic acid
Tox21_112148
NSC159686
NSC759125
STL062186
AKOS000104566
Tox21_112148_1
CCG-213425
NSC 159686
NSC 759125
DA-10862
SBI-0206854.P001
CS-0013428
NS00006995
2-hydroxy-4-[(phenylcarbonyl)amino]benzoic acid
AB00298981_08
EN300-2008621
SR-01000248152-1
SR-01000248152-3
BRD-K20431737-001-04-0
BRD-K20431737-001-08-1
Q27293812