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4-Benzylpiperidine

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Identification
Molecular formula
C12H17N
CAS number
31252-42-3
IUPAC name
4-benzylpiperidine
State
State

At room temperature, 4-benzylpiperidine is usually found as a liquid.

Melting point (Celsius)
10.00
Melting point (Kelvin)
283.15
Boiling point (Celsius)
248.00
Boiling point (Kelvin)
521.15
General information
Molecular weight
175.28g/mol
Molar mass
175.2760g/mol
Density
1.0060g/cm3
Appearence

4-Benzylpiperidine is typically a colorless to pale yellow liquid. It may also be identified as an oily substance with a distinct odor characteristic of piperidines.

Comment on solubility

Solubility of 4-benzylpiperidine

4-benzylpiperidine, with the chemical formula C11H15N, exhibits interesting solubility characteristics in various solvents. Understanding its solubility is crucial for applications in organic synthesis and medicinal chemistry.

Solubility Insights:

  • 4-benzylpiperidine is generally considered to be moderately soluble in polar organic solvents such as ethanol and methanol.
  • It displays limited solubility in water due to its hydrophobic benzyl group, which decreases the overall polarity of the molecule.
  • In non-polar solvents, its solubility tends to increase, making it more soluble in compounds like diethyl ether and chloroform.

As a rule of thumb, "like dissolves like"—the degree of solubility dramatically varies depending on the solvent type. When considering reactions or formulations, it's essential to keep in mind:

  • The influence of temperature on solubility; often, solubility improves with higher temperatures.
  • The potential formation of salts with acids, which may improve the overall aqueous solubility of 4-benzylpiperidine.

In conclusion, while 4-benzylpiperidine has favorable solubility in certain organic solvents, its interaction with water is much less favorable, necessitating careful consideration in various chemical processes.

Interesting facts

Interesting Facts about 4-benzylpiperidine

4-benzylpiperidine is a fascinating compound that belongs to the piperidine class of chemicals, known for their cyclic structure which plays a significant role in the compound's chemical behavior and potential applications. Here are some key points to consider:

  • Cyclic Structure: The piperidine ring provides 4-benzylpiperidine with unique properties, making it a versatile scaffold in medicinal chemistry.
  • Pharmacological Potential: Compounds containing a piperidine moiety are often studied for their ability to interact with various biological targets. This compound may exhibit interesting pharmacological activities.
  • Research Applications: 4-benzylpiperidine is utilized in research settings to develop and optimize new therapeutic agents, particularly in the fields of neuroscience and psychiatry.
  • Analytical Chemistry: Due to its distinct structural characteristics, it is also a subject of interest in analytical chemistry, where techniques such as chromatography can be employed for its separation and analysis.
  • Historical Insights: The study of piperidine derivatives has a rich history, with their synthesis and applications dating back several decades, impacting various fields including pharmaceuticals.

As summed up succinctly by chemists, "the exploration of piperidine derivatives, including 4-benzylpiperidine, showcases the profound intersection of organic chemistry and pharmacology." This compound not only fuels curiosity but also highlights the endless possibilities within chemical research and development.

Synonyms
4-Benzylpiperidine
31252-42-3
Piperidine, 4-(phenylmethyl)-
Piperidine, 4-benzyl-
4-(Phenylmethyl)piperidine
EINECS 250-535-0
NSC 30346
BRN 0132339
JDF1T4667S
NSC-30346
DTXSID3067603
5-20-06-00439 (Beilstein Handbook Reference)
RefChem:518552
DTXCID6038322
250-535-0
InChI=1/C12H17N/c1-2-4-11(5-3-1)10-12-6-8-13-9-7-12/h1-5,12-13H,6-10H
4-Benzyl-piperidine
MFCD00006006
4-benzylpiperdine
Phenyl(4-piperidyl)methane
CHEMBL144129
alpha-(4-Piperidyl)toluene
UNII-JDF1T4667S
4-benzylpiperidin
4- benzylpiperidin
4-benzyl piperdine
4-benzyl piperidin
4-benzyl-piperidin
4-benzyl piperidine
4-phenylmethylpiperidine
4-Benzylpiperidine, 99%
WLN: T6MTJ D1R
Oprea1_832871
SCHEMBL42600
SCHEMBL87612
SCHEMBL447561
SCHEMBL3139398
SCHEMBL3955954
SCHEMBL6002937
SCHEMBL6604926
SCHEMBL8335932
SCHEMBL12274710
SCHEMBL27525435
HMS5118L17
NSC30346
STR03314
BDBM50004317
SBB027306
STL124106
AKOS000118811
AB00568
AC-6673
CS-W017439
FB52865
LF-0509
SY018908
B0387
NS00029048
ST45255376
EN300-19578
F040311
Q4637101
4-(Phenylmethyl)piperidine;Phenyl(4-piperidyl)methane
F0850-6736
Z104474316