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Arsphenamine

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Identification
Molecular formula
C12H15AsCl2NO2
CAS number
139-93-5
IUPAC name
[4-[bis(2-chloroethyl)amino]phenyl]arsonic acid
State
State

Arsphenamine is generally a solid at room temperature. When stored under proper conditions, it remains stable in its solid form, though care must be taken to avoid exposure to air and moisture which can degrade the compound over time.

Melting point (Celsius)
189.00
Melting point (Kelvin)
462.15
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.15
General information
Molecular weight
343.63g/mol
Molar mass
343.6310g/mol
Density
1.3500g/cm3
Appearence

Arsphenamine typically appears as a yellowish powder. It can also be found in crystalline form, which might make it appear differently based on the specific preparation and storage conditions. It is sensitive to oxidation and can darken in color upon exposure to air.

Comment on solubility

Solubility of 4-[bis(2-chloroethyl)amino]phenyl]arsonic acid

The solubility of 4-[bis(2-chloroethyl)amino]phenyl]arsonic acid, often referred to as an organic arsenical compound, can be quite complex. Understanding its solubility is crucial for practical applications in chemistry and pharmacology. Here are some notable points regarding its solubility:

  • Polarity: This compound exhibits a balance of polar and non-polar characteristics due to its functional groups, which can influence its solubility in different solvents.
  • Water Solubility: Generally, organic arsenicals tend to have limited solubility in water. However, various factors such as pH and temperature can play a significant role.
  • Solvent Compatibility: The compound may dissolve better in organic solvents like dichloromethane or dimethyl sulfoxide (DMSO) than in water.
  • pH Sensitivity: The solubility can increase in acidic or basic conditions depending on ionization of functional groups present.

In summary, understanding the solubility of 4-[bis(2-chloroethyl)amino]phenyl]arsonic acid requires a comprehensive look into its molecular structure, solvent interactions, and environmental conditions. As noted, factors such as polarity, solvent type, and pH can greatly influence its solubility characteristics:

"The chemistry of solubility is often a dance between structure and solvent."

By investigating these elements, researchers can better predict and manipulate the behavior of this compound in various chemical contexts.

Interesting facts

Interesting Facts about 4-[bis(2-chloroethyl)amino]phenyl]arsonic acid

4-[bis(2-chloroethyl)amino]phenyl]arsonic acid, often referred to by its common name, is a notable compound in the field of medicinal chemistry and environmental science. Here are some key points to consider:

  • Medicinal Use: Historically, this compound has been studied for its applications in treating various types of cancer. Its structure allows it to interact with biological systems, offering potential therapeutic benefits.
  • Mechanism of Action: The compound acts as an alkylating agent by introducing a chloroethyl group that can modify DNA, which is crucial in the context of targeting cancer cells.
  • Environmental Concerns: As an organoarsenic compound, it raises important environmental issues. The presence of arsenic in any compound poses potential toxicity, making it crucial for scientists to assess and manage its environmental impact.
  • Synthesis Challenges: The synthesis of this compound may present difficulties due to the handling of the chloroethyl groups and arsenic. Chemists must take precautionary measures when working with such reagents to prevent harmful exposure.
  • Research Developments: Ongoing studies focus on modifying the structure to enhance its efficacy while reducing toxicity. Understanding its mechanisms better may lead to safer derivatives for clinical use.

In summary, 4-[bis(2-chloroethyl)amino]phenyl]arsonic acid serves as an excellent example of the interplay between medicinal chemistry and environmental safety. As a compound that has been investigated for its potential to combat cancer, it represents both promise and caution in scientific research.

Synonyms
5185-71-7
BRN 2852551
p-ARSANILIC ACID, N,N-BIS(2-CHLOROETHYL)-
N,N-Bis(2-chloroethyl)-p-arsanilic acid
DTXSID20199804
DTXCID40122295