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4-Bromopyrazole

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Identification
Molecular formula
C3H3BrN2
CAS number
2075-45-8
IUPAC name
4-bromo-1H-pyrazole
State
State

At room temperature, 4-Bromopyrazole is a solid. It is typically an odorless crystalline powder, making it easy to handle and store.

Melting point (Celsius)
71.00
Melting point (Kelvin)
344.15
Boiling point (Celsius)
171.00
Boiling point (Kelvin)
444.15
General information
Molecular weight
160.98g/mol
Molar mass
160.9790g/mol
Density
1.8485g/cm3
Appearence

4-Bromopyrazole generally appears as a white to off-white crystalline solid. It may come in small crystals or powdered form, which is relatively stable under normal conditions. The compound is known for its utility in various chemical syntheses and biological research.

Comment on solubility

Solubility of 4-bromo-1H-pyrazole

4-bromo-1H-pyrazole, with the chemical formula C3H3BrN2, demonstrates intriguing solubility characteristics which can be attributed to its molecular structure. Understanding its solubility is important for various applications in organic chemistry and material science.

The solubility behavior of this compound can be summarized as follows:

  • Solvent Compatibility: 4-bromo-1H-pyrazole is generally soluble in polar organic solvents such as dimethyl sulfoxide (DMSO) and methanol.
  • Hydrophobic Nature: It exhibits limited solubility in non-polar solvents, which makes it less favorable for reactions in non-polar environments.
  • Influence of Bromine: The presence of the bromine atom contributes to its solubility properties, influencing hydrogen bonding and van der Waals interactions.

According to various studies, “the solubility of 4-bromo-1H-pyrazole in water is quite low,” which poses challenges for applications requiring aqueous conditions. Thus, it is important to consider these solubility parameters when planning its use in synthesis or formulation processes.

Overall, the solubility of 4-bromo-1H-pyrazole represents a balance that reflects its unique chemical structure, making it a compound of notable interest.

Interesting facts

Interesting Facts about 4-Bromo-1H-Pyrazole

4-Bromo-1H-pyrazole is a fascinating compound that has garnered considerable attention in the field of organic chemistry. It is part of the pyrazole family, which consists of five-membered aromatic rings containing two adjacent nitrogen atoms. Here are some key points to note about this intriguing compound:

  • Biological Activity: Compounds like 4-bromo-1H-pyrazole are known to exhibit a range of biological activities, making them potential candidates for drug discovery and development. Research has shown that pyrazole derivatives can act as effective inhibitors of various enzymes and pathways in biological systems.
  • Versatile Synthesis: The synthesis of 4-bromo-1H-pyrazole can be achieved through various methods, which often involve the bromination of pyrazole derivatives. This versatility makes it an attractive compound for researchers looking to explore numerous synthetic routes.
  • Application in Agrochemicals: This compound is also being explored for its potential application in the field of agrochemicals. Research indicates that pyrazole derivatives may have fungicidal and herbicidal properties, which could lead to the development of new pesticides that are both effective and environmentally friendly.
  • Material Science: The unique properties of 4-bromo-1H-pyrazole make it a subject of interest in material science. Its ability to form stable complexes with metals allows for the investigation of its applications in coordination chemistry and as a stabilizer in various formulations.
  • Research Significance: The study of 4-bromo-1H-pyrazole contributes to a broader understanding of the chemistry of nitrogen-containing heterocycles. Its significance extends into fields such as medicinal chemistry, where its derivatives may offer valuable insights into the development of new therapeutic agents.

In summary, 4-bromo-1H-pyrazole is a compound rich in potential and possibility. Its broad applications and biological significance make it a compound worth studying and integrating into various scientific pursuits.

Synonyms
4-Bromopyrazole
2075-45-8
1H-Pyrazole, 4-bromo-
PYRAZOLE, 4-BROMO-
4-Brompyrazole
NSC 522023
BRN 0106510
DTXSID50174826
5-23-04-00172 (Beilstein Handbook Reference)
DTXCID1097317
1H-Pyrazole, 4-bromo-(9CI)
wvgcpedbfhehez-uhfffaoysa-n
4-Bromo-1H-pyrazole
MFCD00075602
CHEMBL4440111
4-bromo-pyrazole
NSC-522023
4-Bromopyrazole; NSC 522023
4-bromo pyrazole
BYZ
JCB5VB9RTA
4-Bromo-1-H-pyrazole
4-Bromopyrazole, 99%
WLN: T5MNJ DE
SCHEMBL10169
ALBB-000287
BDBM50622824
NSC522023
STK301300
AKOS000304500
AB02892
AC-2709
AS-5543
CS-W009265
BP-21496
HY-78243
SY002635
DB-262940
B3745
EN300-50991
AC-907/25014004
AE-641/00649055
Q27458577
F0001-0740
Z275169750