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4-Bromo-2-(trifluoromethyl)-1H-benzimidazole

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Identification
Molecular formula
C8H4BrF3N2
CAS number
189628-39-3
IUPAC name
4-bromo-2-(trifluoromethyl)-1H-benzimidazole
State
State

At room temperature, 4-bromo-2-(trifluoromethyl)-1H-benzimidazole is typically found in a solid state.

Melting point (Celsius)
129.00
Melting point (Kelvin)
402.00
Boiling point (Celsius)
276.00
Boiling point (Kelvin)
549.00
General information
Molecular weight
266.03g/mol
Molar mass
266.0170g/mol
Density
1.8124g/cm3
Appearence

It is a solid compound which typically appears as a crystalline powder.

Comment on solubility

Solubility of 4-bromo-2-(trifluoromethyl)-1H-benzimidazole

The solubility of 4-bromo-2-(trifluoromethyl)-1H-benzimidazole is influenced by its unique structure and functional groups. This compound possesses characteristics that can affect its interactions with solvents. Here are some key points regarding its solubility:

  • Polarity: Due to the presence of the trifluoromethyl group, the compound may exhibit increased polarity. This can potentially enhance its solubility in polar solvents such as water and alcohols.
  • Non-polar Solvents: The benzimidazole ring itself has aromatic characteristics, which might lead to moderate solubility in non-polar solvents like hexane or toluene.
  • Temperature Dependency: Solubility can also be temperature dependent; thus, heating may increase the solubility of 4-bromo-2-(trifluoromethyl)-1H-benzimidazole in certain solvents.
  • Concrete Examples: When dissolved in aprotic solvents such as DMSO or DMF, the compound may show better solubility compared to protic solvents.

Overall, the solubility of 4-bromo-2-(trifluoromethyl)-1H-benzimidazole can be classified as moderate in terms of compatibility with various solvent types. Careful consideration of the solvent properties will yield the best results for practical applications.

Interesting facts

Interesting Facts about 4-Bromo-2-(Trifluoromethyl)-1H-Benzimidazole

4-Bromo-2-(trifluoromethyl)-1H-benzimidazole is a fascinating organic compound that belongs to the benzimidazole family. This class of compounds is widely recognized for its diverse applications in several fields, particularly in medicinal chemistry. Here are some captivating aspects of this particular compound:

  • Biological Activity: Benzimidazole derivatives, like 4-bromo-2-(trifluoromethyl)-1H-benzimidazole, have gained attention for their biological properties. Many compounds in this class exhibit antimicrobial, antifungal, and even antitumor activity, making them interesting candidates for drug development.
  • Structural Features: The presence of the bromo and trifluoromethyl groups significantly alters the electronic distribution within the molecule. These substituents can enhance the reactivity and solubility of the compound, leading to improved pharmacological profiles.
  • Research Implications: Recent studies suggest that compounds similar to 4-bromo-2-(trifluoromethyl)-1H-benzimidazole may play critical roles in the design of new pharmaceuticals, especially targeting specific biological pathways. The research continues to uncover their potential as inhibitors in various biochemical processes.
  • Environmental Considerations: With the increasing concern over chemical safety and environmental impact, the study of halogenated compounds like this one is vital. Understanding their stability and degradation can help in assessing their eco-toxicity.
  • Industrial Applications: Apart from pharmaceuticals, benzimidazole derivatives are employed in agriculture as pesticides and herbicides, showcasing their versatility beyond medicinal chemistry.

In conclusion, 4-bromo-2-(trifluoromethyl)-1H-benzimidazole stands out for its potential in various scientific disciplines. As researchers continue to explore its properties and applications, this compound could contribute significantly to advancements in both medicine and environmental science.

Synonyms
6587-23-1
BENZIMIDAZOLE, 4-BROMO-2-(TRIFLUOROMETHYL)-
4-Bromo-2-(trifluoromethyl)benzimidazole
DTXSID00216048
DTXCID00138539
4-bromo-2-(trifluoromethyl)-1H-benzimidazole
4-Bromo-2-(trifluoromethyl)-1H-benzo[d]imidazole
4-bromo-2-(trifluoromethyl)-1H-1,3-benzodiazole
7-Bromo-2-(trifluoromethyl)-1H-benzo[d]imidazole
MFCD01658374
MWSWJWXZVTVPEQ-UHFFFAOYSA-N
AKOS023171102
PS-7333
DB-205702
CS-0326718