Skip to main content

4-bromo-6-nitro-2-(trifluoromethyl)-1H-benzimidazole

ADVERTISEMENT
Identification
Molecular formula
C8H3BrF3N3O2
CAS number
141920-92-9
IUPAC name
4-bromo-6-nitro-2-(trifluoromethyl)-1H-benzimidazole
State
State

At room temperature, 4-bromo-6-nitro-2-(trifluoromethyl)-1H-benzimidazole is a solid. It is stable under normal temperatures and pressures, commonly stored in a dry, cool area to maintain its stability.

Melting point (Celsius)
168.00
Melting point (Kelvin)
441.15
Boiling point (Celsius)
420.00
Boiling point (Kelvin)
693.15
General information
Molecular weight
312.00g/mol
Molar mass
312.0010g/mol
Density
1.8000g/cm3
Appearence

This compound typically appears as a yellow crystalline solid. The color can range from light to dark yellow depending on the purity and specific crystal form. It's generally a fine powder or small crystals.

Comment on solubility

Solubility of 4-bromo-6-nitro-2-(trifluoromethyl)-1H-benzimidazole

The solubility of 4-bromo-6-nitro-2-(trifluoromethyl)-1H-benzimidazole can be quite intriguing due to its unique structural components. This compound contains both bromine and nitro groups, which can influence its solubility characteristics in various solvents.

Generally, the solubility of such compounds can be summarized as follows:

  • Polar Solvents: 4-bromo-6-nitro-2-(trifluoromethyl)-1H-benzimidazole tends to be more soluble in polar solvents such as water and alcohols, due to intermolecular interactions.
  • Non-Polar Solvents: In contrast, the presence of trifluoromethyl may impart some degree of non-polarity, leading to potential solubility in solvents like dichloromethane and toluene.
  • Temperature Effects: Solubility can also be temperature-dependent; as the temperature increases, solubility in many cases tends to increase due to enhanced molecular motion.
  • pH Influence: The pH of the solution can significantly affect solubility especially for compounds with functional groups capable of protonation or deprotonation.

To quote a well-known principle, "like dissolves like," meaning that the solubility will be significantly influenced by the nature of the solvent used in conjunction with the compound's characteristics. Therefore, careful consideration of the solvent's properties is essential in predicting the solubility behavior of this complex compound.

Interesting facts

Interesting Facts about 4-bromo-6-nitro-2-(trifluoromethyl)-1H-benzimidazole

4-bromo-6-nitro-2-(trifluoromethyl)-1H-benzimidazole is a fascinating compound that integrates the properties of both halogens and nitro groups in its molecular structure. This compound is a derivative of benzimidazole, a class of compounds that has gained attention for their numerous biological activities.

Key Features

  • Pharmacological Potential: Compounds related to benzimidazole often exhibit a range of biological activities, including anti-inflammatory, anti-cancer, and anti-viral effects. The presence of both bromine and nitro substitutions could further enhance these biological properties.
  • Electrophilic Nature: The trifluoromethyl group is known for making compounds more electrophilic, influencing the reactivity of 4-bromo-6-nitro-2-(trifluoromethyl)-1H-benzimidazole in various chemical reactions.
  • Versatile Building Block: This compound serves as an important synthetic precursor in organic chemistry, allowing for the construction of more complex molecules through various reactions such as nucleophilic substitution.

In the scientific community, compounds like 4-bromo-6-nitro-2-(trifluoromethyl)-1H-benzimidazole are often explored for their potential applications in medicinal chemistry. As research continues, we may uncover even more exciting uses for this compound.

Quote from a Research Chemist: "Understanding the intricacies of compound substitutions not only allows us to predict reactivity but also opens the door to synthesizing new therapeutic agents."

In summary, the unique structure of 4-bromo-6-nitro-2-(trifluoromethyl)-1H-benzimidazole presents numerous opportunities for scientific exploration, enabling chemists to venture into new medicinal territories and uncover novel applications.

Synonyms
BENZIMIDAZOLE, 4-BROMO-6-NITRO-2-(TRIFLUOROMETHYL)-
BRN 0927197
6609-37-6
4-Bromo-6-nitro-2-(trifluoromethyl)benzimidazole
DTXSID60216281
DTXCID60138772
SCHEMBL15023797
4-bromo-6-nitro-2-(trifluoromethyl)-1H-benzo[d]imidazole