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Phenylbutazone

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Identification
Molecular formula
C19H20N2O2
CAS number
50-33-9
IUPAC name
4-butyl-1-phenyl-pyrazolidine-3,5-dione
State
State

At room temperature, phenylbutazone is in a solid state.

Melting point (Celsius)
105.00
Melting point (Kelvin)
378.15
Boiling point (Celsius)
185.00
Boiling point (Kelvin)
458.15
General information
Molecular weight
308.37g/mol
Molar mass
308.3720g/mol
Density
1.3000g/cm3
Appearence

Phenylbutazone appears as a white or slightly yellow, crystalline powder. It is generally odorless.

Comment on solubility

Solubility Characteristics of 4-butyl-1-phenyl-pyrazolidine-3,5-dione

The solubility of 4-butyl-1-phenyl-pyrazolidine-3,5-dione can be influenced by several factors related to its molecular structure.

General Solubility Insights

This compound exhibits interesting solubility properties that can be summarized as follows:

  • Polarity: As a pyrazolidine derivative, the presence of both butyl and phenyl groups affects its polarity. The butyl group contributes hydrophobic characteristics, while the phenyl ring adds some degree of aromatic stability.
  • Solvent Dependence: It is likely to be more soluble in organic solvents such as ethanol and chloroform compared to polar solvents like water. This is due to its non-polar moieties.
  • Effect of Temperature: Like many organic compounds, solubility can increase with temperature, making it more soluble in warmer solvents.

Conclusion

In summary, while 4-butyl-1-phenyl-pyrazolidine-3,5-dione may not be highly soluble in water due to its hydrophobic characteristics, it shows promising solubility in a variety of organic solvents. Understanding these solubility traits is crucial for applications in pharmaceuticals and material sciences.

Interesting facts

Interesting Facts about 4-butyl-1-phenyl-pyrazolidine-3,5-dione

4-butyl-1-phenyl-pyrazolidine-3,5-dione is a fascinating compound with noteworthy applications and unique properties. Here are some interesting insights:

  • Pharmaceutical Relevance: This compound belongs to the class of pyrazolidine derivatives, which have garnered attention in medicinal chemistry for their potential therapeutic applications, particularly as anti-inflammatory agents.
  • Structural Significance: The presence of both butyl and phenyl groups enhances the compound's lipophilicity, potentially improving its ability to cross biological membranes.
  • Research Applications: Studies have indicated that compounds similar to 4-butyl-1-phenyl-pyrazolidine-3,5-dione may possess anti-tumor properties, making them candidates for further research in cancer therapeutics.
  • Chemical Stability: Pyrazolidine diones are typically known for their chemical stability, which may attribute to their prolonged biological activity and effectiveness in various applications.
  • Historical Context: The use of pyrazolidine derivatives dates back to the early 20th century, with many derivatives being explored for their pharmacological properties since then.

The compound's structure not only contributes to its biological activities but also makes it a subject of interest for ongoing drug development efforts. Researchers continue to explore the diverse properties of 4-butyl-1-phenyl-pyrazolidine-3,5-dione, hoping to uncover new therapeutic potentials.

Synonyms
Mofebutazone
2210-63-1
Monophenylbutazone
4-butyl-1-phenylpyrazolidine-3,5-dione
Mophebutazone
Mobutazon
Mobutazone
Mobuzon
Mozol
Arcobutine
Monorheumetten
Butazone
Corbuton
Monazan
Monobutyl
Monofen
Monomil
Monozon
Reumatox
Arcomonol tablets
Mofebutazona
Mofebutazonum
Monazone
2 Fdbp
Mofesal
Monazon
4-Butyl-1-phenyl-3,5-pyrazolidinedione
4-Butyl-1-phenyl-3,5-dioxopyrazolidine
3,5-PYRAZOLIDINEDIONE, 4-BUTYL-1-PHENYL-
SPW36WUI5Z
Mofebutazonum [INN-Latin]
2-Phenyl-3,5-dihydroxy-4-butylpyrazolidine
Mofebutazona [INN-Spanish]
NSC 73725
NSC-73725
Monazone (TN)
Mofebutazone (INN)
CHEBI:76252
EINECS 218-641-1
Mofebutazone [INN:DCF]
UNII-SPW36WUI5Z
MOFEBUTAZONE [MI]
MOFEBUTAZONE [INN]
BRN 0213056
1-Phenyl-4-butyl-3,5-pyrazolidinedione
MOFEBUTAZONE [MART.]
4-Butyl-3,5-diketo-1-phenylpyrazolidine
MOFEBUTAZONE [WHO-DD]
DTXSID4023331
Mofebutazonum (INN-Latin)
Mofebutazona (INN-Spanish)
MOFEBUTAZONE (MART.)
5-24-05-00400 (Beilstein Handbook Reference)
1-phenyl-4-n-butyl-3,5-dioxopyrazolidine
DTXCID203331
M01AA02
M02AA02
218-641-1
reojlixkjwxugb-uhfffaoysa-n
MLS002693879
mofebutazon
3, 4-butyl-1-phenyl-
SCHEMBL23506
CHEMBL1892201
HMS3094E11
NSC73725
AKOS015962258
DB13629
HY-W009640
AS-56394
DA-65576
SMR001559820
NS00002551
D07262
G77468
Q6890329