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4-Chloro-1-(4-fluorophenyl)butan-1-one

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Identification
Molecular formula
C10H10ClFO
CAS number
192705-79-6
IUPAC name
4-chloro-1-(4-fluorophenyl)butan-1-one
State
State

The compound is generally a liquid at room temperature. However, under certain conditions or when impurities are present, it may solidify into a crystalline form.

Melting point (Celsius)
32.00
Melting point (Kelvin)
305.15
Boiling point (Celsius)
251.00
Boiling point (Kelvin)
524.15
General information
Molecular weight
202.64g/mol
Molar mass
202.6350g/mol
Density
1.2047g/cm3
Appearence

4-Chloro-1-(4-fluorophenyl)butan-1-one typically appears as a colorless to pale yellow liquid. It may also be found as a crystalline solid under certain conditions. The compound can sometimes emit a mild aromatic odor due to the presence of the phenyl group.

Comment on solubility

Solubility of 4-chloro-1-(4-fluorophenyl)butan-1-one

The solubility of 4-chloro-1-(4-fluorophenyl)butan-1-one can be understood by examining its chemical structure and the intermolecular forces at play. Generally, chemical solubility is influenced by factors such as polarity, molecular weight, and the presence of functional groups. In the case of this compound, several key points are relevant:

  • Polarity: The presence of chlorine and fluorine atoms typically increases the polarity of the molecule, which may enhance its solubility in polar solvents like water.
  • Molecular Weight: As a relatively medium-sized organic compound, its molecular weight can affect its solubility; larger molecules may experience more limitations in solubility.
  • Functional Groups: The carbonyl group (C=O) present in the compound can form hydrogen bonds with water, potentially increasing its aqueous solubility.

However, it is essential to note that solubility also depends on the solvent. While 4-chloro-1-(4-fluorophenyl)butan-1-one may exhibit reasonable solubility in some organic solvents such as ethanol or acetone, its behavior in water can be quite different. Thus, generalizations about solubility should be approached cautiously, as empirical testing usually delivers the best insights.

In conclusion, while there are factors suggesting a level of solubility for 4-chloro-1-(4-fluorophenyl)butan-1-one, definitive claims about its solubility should be supported by experimental data.

Interesting facts

Interesting Facts about 4-Chloro-1-(4-fluorophenyl)butan-1-one

4-Chloro-1-(4-fluorophenyl)butan-1-one is a fascinating compound that belongs to the category of alkyl ketones. Here are some intriguing aspects that might capture your attention:

  • Pharmaceutical Relevance: This compound exhibits structural similarities to various pharmaceutical agents, making it an interesting subject for drug discovery and synthesis. A deeper investigation can reveal potential activities against different biological targets.
  • Halogen Influence: The presence of halogens such as chlorine and fluorine in its structure contributes to its reactivity and may influence its biological characteristics. Fluorinated compounds are often noted for their enhanced metabolic stability.
  • Applications: Research shows that compounds of similar structures are often utilized in fields such as agrochemicals, perfumes, and other specialty chemicals. Understanding their properties can open doors to innovative applications.
  • Synthetic Pathways: The synthesis of 4-chloro-1-(4-fluorophenyl)butan-1-one might involve interesting reactions including nucleophilic substitutions and oxidation processes, which are crucial in organic chemistry.

As noted in the realm of organic chemistry, "The exploration of structural motifs can lead to greater insights into both reactivity and function." Thus, studying this compound does not only further our understanding of ketones but also opens up avenues for potential research and development.


In conclusion, 4-chloro-1-(4-fluorophenyl)butan-1-one exemplifies the rich interplay between structure and function within organic compounds, embodying both scientific curiosity and potential practical applications.

Synonyms
4-Chloro-4'-fluorobutyrophenone
3874-54-2
3-(4-Fluorobenzoyl)propyl chloride
1-Butanone, 4-chloro-1-(4-fluorophenyl)-
4'-Fluoro-4-chlorobutyrophenone
4-Fluorobenzoylpropyl chloride
4-Chloro-p-fluorobutyrophenone
p-Fluorobenzoylpropyl chloride
p-Fluoro-4-chlorobutyrophenone
Butyrophenone, 4-chloro-4'-fluoro-
3-Chloro-4'-fluorobutyrophenone
gamma-Chloro-p-fluorobutyrophenone
3-(p-Fluorobenzoyl)propyl chloride
3-Chloropropyl 4'-fluorophenyl ketone
DTXSID3057729
4-(p-Fluorophenyl)-4-oxobutyl chloride
4-(4-Fluorophenyl)-4-oxobutyl chloride
FVL03C7JRR
NSC 87082
gamma-Chloro-p-fluorobutyrophene
p-Fluoro-gamma-chlorobutyrophenone
gamma-Chloro-4-fluorobutyrophenone
EINECS 223-395-3
NSC-87082
4-CHLORO-1-(4-FLUOROPHENYL)-1-BUTANONE
DTXCID4031518
1-CHLORO-4-(4-FLUOROPHENYL)-4-OXOBUTANE
3-(4-FLUOROPHENYLCARBONYL)-1-CHLOROPROPANE
4Chloropfluorobutyrophenone
pFluoro4chlorobutyrophenone
4'Fluoro4chlorobutyrophenone
pFluorobenzoylpropyl chloride
4Fluorobenzoylpropyl chloride
gammaChloropfluorobutyrophenone
pFluorogammachlorobutyrophenone
gammaChloro4fluorobutyrophenone
Butyrophenone, 4chloro4'fluoro
3(pFluorobenzoyl)propyl chloride
3(4Fluorobenzoyl)propyl chloride
4(pFluorophenyl)4oxobutyl chloride
4(4Fluorophenyl)4oxobutyl chloride
3Chloropropyl 4'fluorophenyl ketone
1Butanone, 4chloro1(4fluorophenyl)
223-395-3
4-chloro-1-(4-fluorophenyl)butan-1-one
4-chloro-4-fluorobutyrophenone
3-Chloropropyl 4-fluorophenyl ketone
MFCD00001007
.gamma.-Chloro-p-fluorobutyrophenone
.gamma.-Chloro-4-fluorobutyrophenone
.omega.-Chloro-p-fluorobutyrophenone
p-Fluoro-.gamma.-chlorobutyrophenone
p-Fluoro-.omega.-chlorobutyrophenone
UNII-FVL03C7JRR
4-Chloro-1-(4-fluorophenyl)-1-oxobutane
NCIOpen2_005403
SCHEMBL318467
4-Chlor-4'-fluor-butyrophenon
4-chloro-4'-flurobutyrophenone
4-chloro-4'-flourobutyrophenone
CHEMBL3561872
HXAOUYGZEOZTJO-UHFFFAOYSA-
4-chloro-4' -fluorobutyrophenone
4-chloro-4'-fluoro-butyrophenone
.gamma.-Chloro-p-fluorobutyrophene
omega-Chloro-4-fluorobutyrophenone
p-fluoro-gamma-chloro butyrophenone
NSC87082
Tox21_113749
.omega.-Chloro-4-fluorobutyrophenone
BBL009718
STL141083
1-chloro-3-(4-fluorobenzoyl)propane
AKOS000120240
gamma-(p-fluorobenzoyl)propyl chloride
1-chloro-3-(4-fluorobenzoyl)-propane
CS-W009108
FC06647
4-Chloro-4'-fluorobutyrophenone, 97%
4-oxo-4-(4-fluorophenyl)butyl chloride
NCGC00253619-01
AC-10958
SY016889
CAS-3874-54-2
1-chloro-3-(p-fluorophenylcarbonyl)propane
DB-049325
4-chloro-1-(4-fluoro-phenyl)-butan-1-one
4-Chloro-1-(4-fluorophenyl)-1-butanone #
NS00019720
EN300-21297
D78020
SR-01000944706
SR-01000944706-1
Q27278227
4-Chloro-4 inverted exclamation mark -fluorobutyrophenone
InChI=1/C10H10ClFO/c11-7-1-2-10(13)8-3-5-9(12)6-4-8/h3-6H,1-2,7H2
4-chloro-4'-fluorobutyrophenone;4-chloro-1-(4-fluorophenyl)butan-1-one;1-butanone, 4-chloro-1-(4-fluorophenyl)-;butyrophenone, 4-chloro-4'-fluoro-;4-chloro-4'-fluorobutyrophenone 4-chloro-1-(4-fluorophenyl)butan-1-one 1-butanone, 4-chloro-1-(4-fluorophenyl)- butyrophenone, 4-chloro-4'-fluoro-