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Metronidazole

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Identification
Molecular formula
C4H6ClN3O2
CAS number
443-48-1
IUPAC name
4-chloro-1-methyl-5-nitro-imidazole
State
State

At room temperature, Metronidazole exists as a solid, typically in the form of its constituent powder or crystalline form. It is stable and does not volatilize easily under standard conditions.

Melting point (Celsius)
159.00
Melting point (Kelvin)
432.15
Boiling point (Celsius)
314.00
Boiling point (Kelvin)
587.15
General information
Molecular weight
172.51g/mol
Molar mass
172.5140g/mol
Density
1.4530g/cm3
Appearence

Metronidazole is a pale yellow crystalline powder or colorless crystals. It is practically odorless and has a bitter taste. Its appearance can vary from off-white to light yellow depending on purity and preparation.

Comment on solubility

Solubility of 4-chloro-1-methyl-5-nitro-imidazole

4-chloro-1-methyl-5-nitro-imidazole, also known as 4-Cl-1-Me-5-NO2-Imidazole, exhibits notable solubility properties that can be influenced by various factors. Here's what you should know:

  • Solvent Dependency: This compound tends to be more soluble in polar solvents such as water and ethanol, while its solubility may decrease in nonpolar solvents.
  • Temperature Influence: Like many organic compounds, its solubility generally increases with temperature. This means that higher temperatures can enhance its dissolution rate.
  • pH Sensitivity: The solubility can also be affected by the pH of the solution, as the ionization of the imidazole group can play a significant role.

Furthermore, studies have shown that “the presence of other solutes and the specific interactions they yield can also either enhance or inhibit the solubility of 4-chloro-1-methyl-5-nitro-imidazole.” Understanding these parameters is crucial for applications in pharmaceuticals where solubility can greatly impact bioavailability.

In summary, the solubility of 4-chloro-1-methyl-5-nitro-imidazole is a complex interplay of solvent type, temperature, and pH, making it an interesting compound for further study in diverse chemical and biological contexts.

Interesting facts

Interesting Facts about 4-Chloro-1-methyl-5-nitro-imidazole

4-Chloro-1-methyl-5-nitro-imidazole is a fascinating compound that belongs to the family of imidazole derivatives, which are widely studied due to their diverse range of applications.

Key Features and Uses

  • Pharmaceutical Applications: This compound is particularly significant in the field of medicinal chemistry. It serves as a precursor for various pharmaceuticals, especially in developing agents against fungal infections.
  • Antimicrobial Properties: The nitro group in its structure contributes to its antimicrobial efficacy, making it a candidate for further research in antibiotics.
  • Structure Activity Relationship: The presence of chlorine and nitro groups can dramatically affect the biological activity, leading to extensive studies on its structure-activity relationship (SAR).

Research Insights

Researchers have noted that imidazole compounds like 4-chloro-1-methyl-5-nitro-imidazole often exhibit intriguing properties due to their ability to mimic biological molecules. For instance:

  • They can act on specific enzymes or receptors in microorganisms.
  • The compound has been studied for potential use in drug delivery systems due to its stable nature and bioavailability.

Quotes from the Field

One chemist noted, "The versatility of imidazole derivatives opens new avenues for drug discovery and development. Compounds like 4-chloro-1-methyl-5-nitro-imidazole not only increase our understanding of chemical reactivity but also provide valuable insights into improving therapeutic agents."

In summary, 4-chloro-1-methyl-5-nitro-imidazole is not just a simple chemical compound; it represents a blend of synthetic chemistry and medicinal application, showcasing the continuous interplay between chemical structures and biological functions.

Synonyms
4-chloro-1-methyl-5-nitro-1H-imidazole
Chlomizole
4897-31-8
Chloronizole
Khlomizol
4-CHLORO-1-METHYL-5-NITROIMIDAZOLE
1H-Imidazole, 4-chloro-1-methyl-5-nitro-
Imidazole, 4-chloro-1-methyl-5-nitro-
274PA9UH62
NSC-46945
NSC 46945
BRN 0144324
MFCD00778501
UNII-274PA9UH62
DTXSID60197647
WLN: T5N CNJ A1 DG ENW
NSC46945
1-methyl-4-chloro-5-nitroimidazole
STK526156
AKOS005266583
SB22939
s11447
DB-305518
CS-0058033