Interesting facts
Interesting Facts about 4-Chloro-2-(2-furylmethylamino)-5-sulfamoyl-benzoic Acid
4-Chloro-2-(2-furylmethylamino)-5-sulfamoyl-benzoic acid is a fascinating compound with several noteworthy characteristics, particularly in the realm of medicinal chemistry.
Structural Features
- Sulfonamide Group: The presence of a sulfamoyl group imparts significant pharmacological properties, often associating this compound with antibacterial and diuretic properties.
- Chlorine Substituent: The chlorine atom enhances lipophilicity, which can affect the compound's ability to cross biological membranes.
- Aromatic Structure: The benzoic acid framework contributes to a variety of chemical reactivity, making it useful in synthesis and a target for structural modifications.
Applications
This compound belongs to a class of sulfonamide compounds, which have been historically significant in the development of antibiotics. They work primarily by:
- Inhibiting bacterial folic acid synthesis
- Exhibiting a broad-spectrum of activity against various pathogens
Biological Importance
4-Chloro-2-(2-furylmethylamino)-5-sulfamoyl-benzoic acid has shown promise in various fields. Some key points include:
- Potential Anticancer Activity: Compounds with similar structures have been researched for their effects in oncology.
- Research Interest: Ongoing studies aim to explore its mechanisms of action and enhance its therapeutic efficacy.
Quote from the Pharmacological Field
As one researcher put it, “The sulfonamide class continues to be a cornerstone in the development of newer therapeutic agents.” This statement underscores the ongoing relevance of compounds like 4-chloro-2-(2-furylmethylamino)-5-sulfamoyl-benzoic acid in the pharmaceutical landscape.
In summary, the multifaceted nature of 4-Chloro-2-(2-furylmethylamino)-5-sulfamoyl-benzoic acid makes it a compound of great interest, bridging the gap between synthetic chemistry and practical medical applications.
Synonyms
furosemide
54-31-9
Frusemide
Lasix
Furanthril
Furosemid
Errolon
Fusid
Aisemide
Beronald
Desdemin
Frusemin
Fuluvamide
Furanthryl
Fursemide
Lowpstron
Prefemin
Rosemide
Salix
Eutensin
Frusetic
Furantril
Fursemid
Logirene
Macasirool
Marsemide
Promedes
Trofurit
Frusid
Fulsix
Furesis
Katlex
Lasilix
Mirfat
Oedemex
Radonna
Seguril
Transit
Lasex
Lazix
Urex
Furanturil
Urosemide
Aluzine
Dryptal
Frusemid
Frusenex
Impugan
Profemin
Uremide
Disal
Diural
Laxur
Uresix
Urian
Yidoli
Apo-Frusemide
Anfuramaide
Arasemide
Bioretic
Disemide
Diurapid
Diurolasa
Diusemide
Fluidrol
Frusedan
Furobeta
Furodiurol
Furodrix
Furorese
Furosedon
Furosemidum
Furosemix
Furoside
Furosifar
Furovite
Fursemida
Hissuflux
Jenafusid
Lasiletten
Lowpston
Moilarorin
Novosemide
Protargen
Radisemide
Selectofur
Sigasalur
Spirofur
Synephron
Zafimida
Aldalix
Aquarid
Aquasin
Cetasix
Dirine
Discoid
Diurin
Diusil
Diuzol
Dranex
Edemid
Edenol
Farsix
Franyl
Frumex
Frumide
Frusema
Furetic
Furfan
Furmid
Furocot
Furomen
Furomex
Furosan
Furose
Furosix
Furoter
Fursol
Hydrex
Kofuzon
Kolkin
Kutrix
Lasemid
Liside
Luscek
Nelsix
Nicorol
Odemase
Odemex
Promide
Puresis
Radouna
Rusyde
Salurex
Salurid
Uridon
Uritol
4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid
Aldic
Depix
Desal
Eliur
Fluss
Furex
Furix
Golan
Nadis
Retep
Rosis
Vesix
Apo-Furosemide
Furo-puren
Hydro-rapid
Lasix Retard
less Diur
Neo-renal
Furo-Basan
Durafurid
Fuluvamine
Furosemida
Furosemidu
Hydroled
Endural
Nephron
Salinex
Hydro
Urex-M
Mita
Furomide M.D.
Furosemidu [Polish]
Furosemidum [INN-Latin]
4-Chloro-N-(2-furylmethyl)-5-sulfamoylanthranilic acid
Furosemida [INN-Spanish]
LB 502
Benzoic acid, 5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]-
LB-502
2-Furfurylamino-4-chloro-5-sulfamoylbenzoic acid
Furosemide mita
Furosemide oral
Lasix (TN)
4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbenzoic acid
5-(Aminosulfonyl)-4-chloro-2-[(2-furylmethyl)amino]benzoic acid
NCI-C55936
FUROSCIX
4-Chloro-5-sulfamoyl-N-furfuryl-anthranilic acid
Diumide-K
CCRIS 1951
HSDB 3086
4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid
Anthranilic acid, 4-chloro-N-furfuryl-5-sulfamoyl-
EINECS 200-203-6
7LXU5N7ZO5
NSC 269420
NSC-269420
BRN 0840915
Chlor-N-(2-furylmethyl)-5-sulfamylanthranilsaeure
DTXSID6020648
CHEBI:47426
Benzoic acid, 5-(aminosulfonyl)-4-chloro-2-((2-furanylmethyl)amino)-
FUROSEMIDE [MI]
CHEMBL35
FUROSEMIDE [INN]
FUROSEMIDE [JAN]
4-Chloro-2-((furan-2-ylmethyl)amino)-5-sulfamoylbenzoic acid
FUROSEMIDE [HSDB]
FUROSEMIDE [IARC]
FUROSEMIDE [USAN]
MFCD00010549
FUROSEMIDE [VANDF]
5-(Aminosulfonyl)-4-chloro-2-((2-furanylmethyl)amino)benzoic acid
5-(Aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoic acid
FUROSEMIDE [MART.]
Furosemide [USAN:USP:INN:BAN:JAN]
FUROSEMIDE [USP-RS]
FUROSEMIDE [WHO-DD]
FUROSEMIDE [WHO-IP]
DTXCID80648
FUROSEMIDE [GREEN BOOK]
FUROSEMIDE [ORANGE BOOK]
FUROSEMIDE [EP MONOGRAPH]
FUROSEMIDE [USP MONOGRAPH]
FUROSEMIDUM [WHO-IP LATIN]
5-18-09-00555 (Beilstein Handbook Reference)
NSC269420
CAS-54-31-9
NCGC00016241-06
Sal diureticum
4-chloro-2-{[(furan-2-yl)methyl]amino}-5-sulfamoylbenzoic acid
FUROSEMIDE (IARC)
Furosemidum (INN-Latin)
SALIX (MART.)
SALIX [MART.]
Furosemida (INN-Spanish)
FUROSEMIDE (MART.)
FUROSEMIDE (USP-RS)
Furosemide "mita"
FUN
FUROSEMIDE (EP MONOGRAPH)
FUROSEMIDE (USP MONOGRAPH)
5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid
5-(aminosulfonyl)-4-chloro-2-[(furan-2-ylmethyl)amino]benzoic acid
5-(AMINOSULFONYL)-4-CHLORO-2-((2-FURYLMETHYL)AMINO)BENZOIC ACID
Furosemide (USAN:USP:INN:BAN:JAN)
SMR000058202
furosemide ''mita''
SR-01000765380
Hoe-058A
UNII-7LXU5N7ZO5
Tenkofruse
Aquamed
Neosemid
Willows
Zafurida
Frumax
Frusol
Willow
Froop
Salicis cortex
Disal Injection
Willow bark
4-chloro-2-(((furan-2-yl)methyl)amino)-5-sulfamoylbenzoic acid
Lasix Packets
Salix Tablets
Lasix ret
SK-Furosemide
Chlor-N-(2-furylmethyl)-5-sulfamylanthranilsaeure [German]
Salix spp. bark
Furosemide 1%
Furosemide, 4
Furos-A-Vet
Urex M
furosemide (lasix)
Aluzine 20
Aluzine 40
Lasix Syrup 1%
Prestwick_752
Frumil (Salt/Mix)
Aluzine 500
Salix Injection 5%
Furosemida (Spanish)
Furosemide Syrup 1%
Furosemide (Standard)
Spectrum_001100
1z9y
FUROSEMIDE "MITA
Furosemide Injection 5%
SALIX [VANDF]
Prestwick0_000341
Prestwick1_000341
Prestwick2_000341
Prestwick3_000341
Spectrum2_001005
Spectrum3_000437
Spectrum4_000560
Spectrum5_000744
F0182
UPCMLD-DP022
SCHEMBL9811
S883J9JDYX
Oprea1_667724
BSPBio_000401
BSPBio_002054
KBioGR_001259
KBioSS_001580
MLS001066374
MLS001306403
MLS002548896
BIDD:GT0139
DivK1c_000575
SPECTRUM1500310
SPBio_001129
SPBio_002322
BPBio1_000443
Furosemide (JP18/USP/INN)
Furosemide - Bio-X trade mark
GTPL4839
UPCMLD-DP022:001
BDBM25902
HMS501M17
HY-B0135R
KBio1_000575
KBio2_001580
KBio2_004148
KBio2_006716
KBio3_001274
4-chloro-2-(2-furylmethylamino)-5-sulfamoyl-benzoic acid
C03CA01
NINDS_000575
HMS1569E03
HMS1920B03
HMS2090K06
HMS2091H05
HMS2096E03
HMS2233H03
HMS3259M03
HMS3370J22
HMS3655E09
HMS3713E03
HMS3874G03
Pharmakon1600-01500310
Furosemide 1.0 mg/ml in Methanol
SALIX SPP. BARK [WHO-DD]
ALBB-019200
HY-B0135
Tox21_110322
Tox21_202213
Tox21_302971
4-CHLORO-N-FURFURYL-5-SULFAMOYLANTHRANILIC ACID pound>>Furosemide
BBL027780
CCG-40223
furosemide injection 80 mg/ 10 mL
NSC757039
STK177334
WLN: T5OJ B1MR CG FVQ DSZW
AKOS000266625
Tox21_110322_1
BCP9000708
CS-1915
DB00695
FF30276
KS-1226
NC00453
NSC-757039
IDI1_000575
SMP1_000129
NCGC00016241-01
NCGC00016241-02
NCGC00016241-03
NCGC00016241-04
NCGC00016241-05
NCGC00016241-07
NCGC00016241-08
NCGC00016241-10
NCGC00016241-11
NCGC00090893-01
NCGC00090893-02
NCGC00090893-03
NCGC00090893-05
NCGC00090893-06
NCGC00256523-01
NCGC00259762-01
AC-11067
BF166384
BP-13261
SBI-0051389.P003
WILLOW BARK [EMA HERBAL SUBSTANCE]
DB-052536
AB00052001
NS00008630
SALICIS CORTEX [EMA HERBAL SUBSTANCE]
SW196894-3
C07017
D00331
D87719
EN300-126738
AB00052001-10
AB00052001-11
AB00052001_12
AB00052001_13
A830094
Q388801
SR-01000765380-2
SR-01000765380-3
SR-01000765380-7
BRD-K78010432-001-05-8
BRD-K78010432-001-10-8
BRD-K78010432-001-20-7
BRD-K78010432-001-21-5
Z275128584
4-chloro-2-(2-furanylmethylamino)-5-sulfamoylbenzoic acid
Furosemide, British Pharmacopoeia (BP) Reference Standard
Furosemide, European Pharmacopoeia (EP) Reference Standard
4-chloranyl-2-(furan-2-ylmethylamino)-5-sulfamoyl-benzoic acid
Furosemide, United States Pharmacopeia (USP) Reference Standard
4-CHLORO-N-FURFURYL-5-SULFAMOYLANTHRANILIC ACID Furosemide
5-(Aminosulfamyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoic acid
5-(Aminosulfonyl)-4-chloro-2-[(2-furylmethyl)amino]benzoic acid #
5-(AMINOSULFONYL)-4-CHLORO-2-((2-FURANYLMETHY)AMINO)BENZOIC ACID
Furosemide, Pharmaceutical Secondary Standard; Certified Reference Material
Furosemide for peak identification, European Pharmacopoeia (EP) Reference Standard
200-203-6
84931-49-7
SALIX (VARIOUS SPECIES INCLUDING S. PURPUREA L.; S. DAPHNOIDES VILL.; S. FRAGILIS L.)
SALIX (VARIOUS SPECIES INCLUDING S. PURPUREA L.; S. DAPHNOIDES VILL.; S. FRAGILIS L.) [EMA HERBAL SUBSTANCE]
Solubility of 4-chloro-2-(2-furylmethylamino)-5-sulfamoyl-benzoic acid
The solubility characteristics of 4-chloro-2-(2-furylmethylamino)-5-sulfamoyl-benzoic acid (C12H11ClN2O5S) offer intriguing insights into its behavior in different environments. This compound presents a complex solubility profile that can be influenced by various factors. Here’s what we know:
Overall, while 4-chloro-2-(2-furylmethylamino)-5-sulfamoyl-benzoic acid has the potential for solubility in polar solvents, the specific details would require empirical testing to ascertain quantitative values under varied conditions. As a rule of thumb, polar compounds tend to dissolve well in polar solvents, making the understanding of solubility critical for practical applications.