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4-Chloro-o-anisidine

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Identification
Molecular formula
C7H8ClNO
CAS number
2898-00-8
IUPAC name
4-chloro-2-methoxy-aniline
State
State

At room temperature, 4-Chloro-o-anisidine is a solid compound. It is stable under normal conditions but should be handled with care as it may be harmful if inhaled or absorbed through the skin.

Melting point (Celsius)
68.00
Melting point (Kelvin)
341.15
Boiling point (Celsius)
273.00
Boiling point (Kelvin)
546.15
General information
Molecular weight
157.60g/mol
Molar mass
157.5990g/mol
Density
1.3000g/cm3
Appearence

4-Chloro-o-anisidine is typically found as a light tan to white crystalline solid.

Comment on solubility

Solubility of 4-chloro-2-methoxy-aniline

The solubility of 4-chloro-2-methoxy-aniline, a compound classified under amines, is significantly influenced by various factors such as temperature, pH, and the presence of solvents. Understanding its solubility characteristics is essential for practical applications in synthesis and formulation.

Key Factors Affecting Solubility:

  • Polarity: The presence of both the chloro group and the methoxy group contributes to the overall polarity of the molecule, enhancing its ability to interact with polar solvents like water.
  • Hydrogen Bonding: The amine group (-NH2) can engage in hydrogen bonding, which often increases solubility in polar solvents.
  • Temperature: Generally, solubility increases with temperature; thus, higher temperatures may improve the dissolution of 4-chloro-2-methoxy-aniline in solvents.

It is worth noting that:

  • Solvent Choice: Solubility tends to be greater in organic solvents due to the compound’s aromatic nature.
  • pH Influence: The solubility can also vary with pH; the cationic form of amines is often more soluble in acidic conditions.

In summary, 4-chloro-2-methoxy-aniline exhibits variable solubility based on chemical structure, solvent polarity, and external conditions. This makes it a versatile compound in various chemical environments.

Interesting facts

Interesting Facts about 4-Chloro-2-methoxy-aniline

4-Chloro-2-methoxy-aniline, also known by its IUPAC name, is a fascinating aromatic compound featuring both a chloro and a methoxy group attached to an aniline structure. This compound falls within the realm of substituted anilines and has notable implications and uses in various fields, particularly in organic synthesis and material science.

Key Characteristics and Uses:

  • Dye Production: 4-Chloro-2-methoxy-aniline is often utilized as an intermediate in the synthesis of various dyes and pigments. Its unique structure allows for the development of vibrant colors suitable for textiles and inks.
  • Pharmaceutical Applications: The compound may also serve as a precursor for biologically active molecules, contributing to the pharmaceutical industry in the development of new drugs.
  • Research Material: Because of its distinct functional groups, 4-chloro-2-methoxy-aniline is an interesting subject for researchers studying the effects of substitution on aniline derivatives.

Chemical Properties:

In the realm of chemical reactions, the presence of the chloro and methoxy groups impacts the reactivity and the electronic nature of the aniline ring. These substituents can enhance electrophilicity in reactions due to their resonance effects. The compound is also poised for interesting transformations involving nucleophilic substitutions, where the chloro group can be replaced by various other functional groups.

Environmental Considerations:

While exploring the uses of 4-chloro-2-methoxy-aniline, it is vital to acknowledge the environmental implications associated with its synthesis and degradation. Substituted anilines have been under scrutiny due to their potential toxicity and environmental persistence, thus highlighting the importance of understanding their behavior in ecological systems.

In summary, the exploration of 4-chloro-2-methoxy-aniline reveals a compound rich with opportunities for industrial application and scientific research, making it a significant subject for further study within organic chemistry.

Synonyms
4-chloro-2-methoxyaniline
93-50-5
Benzenamine, 4-chloro-2-methoxy-
4-Chloro-2-methoxy-phenylamine
4-Chloro-o-anisidine
p-Chloro-o-anisidine
2-Amino-5-chloroanisole
4-chloro-2-methoxybenzenamine
EINECS 202-251-3
(4-Chloro-2-methoxyphenyl)amine
4-Chloro-2-anisidine
MFCD06801386
2-methoxy-4-chloroaniline
DTXSID5059088
WOXLPNAOCCIZGP-UHFFFAOYSA-
4-chloro-2-methoxyphenylamine
2-AMINO-5-CHLOROANISOLE HYDROCHLORIDE
5-Chloro-2-aminoanisole
TV9MZ8W6NF
2-methoxy-4-chlorobenzenamine
SCHEMBL171279
4-Chloro-2-(methyloxy)aniline
o-ANISIDINE, 4-CHLORO-
DTXCID6048838
Benzenamine,4-chloro-2-methoxy-
1-Amino-4-chloro-2-methoxybenzene
BCP28442
BBL100098
STL301778
AKOS000674032
4-Chloro-2-methoxyaniline, AldrichCPR
FC20021
PS-3458
SB40014
SY104152
DB-057406
CS-0043926
NS00039569
EN300-152623
AN-584/43422715
Z851801172
202-251-3
4-Chloro-2-methoxybenzenamine;(4-Chloro-2-methoxyphenyl)amine;1-Amino-4-chloro-2-methoxybenzene