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4-Chloro-2-nitrobenzenesulfonyl chloride

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Identification
Molecular formula
C6H3Cl2NO4S
CAS number
14621-59-3
IUPAC name
4-chloro-2-nitro-benzenesulfonyl chloride
State
State

This compound is typically in a solid state at room temperature, appearing in the form of yellow crystalline powder.

Melting point (Celsius)
83.00
Melting point (Kelvin)
356.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
269.55g/mol
Molar mass
269.5510g/mol
Density
1.7000g/cm3
Appearence

4-Chloro-2-nitrobenzenesulfonyl chloride typically appears as a yellow crystalline solid. The crystals can vary in size, but maintain a bright to pale yellow color. It is often noted for its distinct appearance among similar compounds.

Comment on solubility

Solubility of 4-chloro-2-nitro-benzenesulfonyl chloride

4-chloro-2-nitro-benzenesulfonyl chloride, a sulfonyl chloride compound, exhibits unique solubility characteristics that are important for its applications. Below are some key points regarding its solubility:

  • Solvent Dependence: This compound is primarily soluble in polar aprotic solvents such as dimethyl sulfoxide (DMSO) and acetone.
  • Lack of Aqueous Solubility: It is generally insoluble in water due to the hydrophobic nature of the benzene ring and the presence of the sulfonyl chloride group, which makes it less able to interact favorably with water molecules.
  • Temperature Influence: As is typical for many organic compounds, temperature can significantly affect the solubility, often increasing solubility at higher temperatures.
  • Reactivity Considerations: Additionally, the presence of the sulfonyl chloride group can lead to hydrolysis in the presence of moisture, impacting the overall solubility and stability of the compound when handled in humid conditions.

In summary, while 4-chloro-2-nitro-benzenesulfonyl chloride is soluble in certain organic solvents, its low solubility in water and reactivity to moisture must be considered for proper handling and application.

Interesting facts

Interesting Facts About 4-Chloro-2-nitro-benzenesulfonyl Chloride

4-Chloro-2-nitro-benzenesulfonyl chloride, often abbreviated as Cl-NBSCl, is a fascinating chemical compound known for its unique reactivity and applications in organic synthesis. Here are some key points that highlight its significance:

  • Versatile Intermediate: This compound serves as a valuable intermediate in the synthesis of various pharmaceuticals, agrochemicals, and dyes. Its ability to participate in nucleophilic substitution reactions makes it an important building block in organic chemistry.
  • Electrophilic Nature: The presence of the sulfonyl chloride group enhances its electrophilic character, allowing it to react readily with nucleophiles. As a result, it can form stable products, which are often vital in medicinal chemistry.
  • Applications in Drug Development: Researchers utilize 4-chloro-2-nitro-benzenesulfonyl chloride for the creation of compounds with biological activity. It can be used in the synthesis of enzyme inhibitors and antibacterial agents.
  • Environmental Considerations: While the compound finds utility in many chemical reactions, it is crucial for chemists to consider its disposal and environmental impact. Proper handling and regulation are essential when working with such halogenated compounds.
  • Reaction Mechanisms: Understanding the reaction mechanisms involving 4-chloro-2-nitro-benzenesulfonyl chloride can provide insights into the broader field of organosulfur chemistry. Mechanistic studies often reveal new pathways for synthetic methodologies.

In the words of renowned chemist, "Chemical synthesis is like composing music; each compound plays its part in a larger symphony of molecular interactions." This sentiment rings true for 4-chloro-2-nitro-benzenesulfonyl chloride, as it harmonizes well with various reactions to yield innovative molecules.

Overall, 4-chloro-2-nitro-benzenesulfonyl chloride stands out not only for its chemical properties but also for its potential to contribute significantly to diverse fields of chemistry.

Synonyms
4-Chloro-2-nitrobenzenesulfonyl chloride
4533-96-4
Benzenesulfonyl chloride, 4-chloro-2-nitro-
2U62Q3CF4S
4-Chloro-2-nitrophenylsulphonyl chloride
NSC-81212
4-Chloro-2-nitrophenylsulfonyl chloride
DTXSID10196483
NSC 81212
o-Nitro-p-chlorobenzene sulfonyl chloride
DTXCID20118974
lyestqkhipxvik-uhfffaoysa-n
4-chloro-2-nitrobenzene-1-sulfonyl chloride
2-Nitro-4-chlorobenzenesulfonyl chloride
EINECS 224-875-5
MFCD02684714
4-chloro-2-nitrobenzenesulfonylchloride
4-Chloro-2-nitro-benzenesulfonyl chloride
UNII-2U62Q3CF4S
SCHEMBL1052777
4-Chlor-2-nitrobenzolsulfochlorid
NSC81212
4-Chloro-2-nitrophenylsulfonylchloride
AKOS000813763
AT40600
FC58954
AS-87179
4-Chloro-2-nitrobenzenesulfonyl chloride #
DB-070639
NS00031524
EN300-30660
4-Chloro-2-nitrobenzenesulfonyl chloride, 97%
F9995-0525