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4-Chloro-2-(trifluoromethyl)benzimidazole

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Identification
Molecular formula
C8H4ClF3N2
CAS number
138926-09-3
IUPAC name
4-chloro-2-(trifluoromethyl)-1H-benzimidazole
State
State

Under standard conditions, 4-Chloro-2-(trifluoromethyl)-1H-benzimidazole is found in a solid state. It tends to remain stable under normal laboratory conditions, but as with any chemical, one should store it in a cool, dry place to ensure its longevity and purity.

Melting point (Celsius)
99.00
Melting point (Kelvin)
372.15
Boiling point (Celsius)
345.90
Boiling point (Kelvin)
619.05
General information
Molecular weight
222.58g/mol
Molar mass
222.5470g/mol
Density
1.5987g/cm3
Appearence

4-Chloro-2-(trifluoromethyl)-1H-benzimidazole typically appears as a white or off-white crystalline powder. It may have a slight odor depending on the purity and specific lot of the compound one is handling.

Comment on solubility

Solubility of 4-chloro-2-(trifluoromethyl)-1H-benzimidazole

4-chloro-2-(trifluoromethyl)-1H-benzimidazole exhibits unique solubility characteristics that are important to understand for its practical applications:

  • Polar Characteristics: The presence of the trifluoromethyl group enhances the polar nature of this compound, which can influence its interactions with solvents.
  • Solvent Compatibility: This compound is more soluble in polar solvents such as dimethyl sulfoxide (DMSO) and methanol when compared to non-polar solvents.
  • Temperature Influence: As with many organic compounds, solubility can be affected by temperature; generally, increased temperatures result in greater solubility.
  • Ionization Potential: Given its nitrogen-containing structure, it may have a tendency to ionize in certain aqueous conditions, further influencing solubility in water.

In summary, the ability of 4-chloro-2-(trifluoromethyl)-1H-benzimidazole to dissolve varies significantly based on the type of solvent used and the environmental conditions such as temperature. Understanding these factors is crucial for applications in pharmaceuticals and chemical processes.

Interesting facts

Interesting Facts about 4-Chloro-2-(trifluoromethyl)-1H-benzimidazole

4-Chloro-2-(trifluoromethyl)-1H-benzimidazole is a fascinating compound that belongs to the class of benzimidazoles, which are known for their diverse biological activities. This compound, in particular, has several noteworthy properties and potential applications.

Key Characteristics

  • Biological Significance: Benzimidazole derivatives, including this compound, are often studied for their anti-parasitic, anti-cancer, and anti-inflammatory effects. They serve as crucial leads in the development of new therapeutic agents.
  • Fluorinated Moiety: The presence of the trifluoromethyl group enhances lipophilicity, which can improve the bioavailability and transport of the compound across biological membranes.
  • Chlorine Substitution: The 4-chloro group can influence the electronic properties and reactivity of the molecule, potentially affecting its interaction with target proteins in biological systems.

Applications

This compound's unique structure allows it to be potentially used in various fields such as:

  • Pharmaceutical Development: As mentioned, its derivatives can be pivotal in drug discovery, particularly for antimicrobial and antifungal agents.
  • Agricultural Science: Compounds with similar structures may serve as pesticides or herbicides, showcasing the versatility of benzimidazole derivatives.
  • Material Science: The properties of halogenated compounds often lend themselves to interesting interdisciplinary applications, such as in the development of advanced materials.

The study of 4-chloro-2-(trifluoromethyl)-1H-benzimidazole opens the door to a wealth of research opportunities and insight into the intricate world of organic synthesis and pharmacology. As Albert Einstein famously said, “The important thing is not to stop questioning. Curiosity has its own reason for existing.” Exploring compounds like this one embodies that spirit of inquiry, pushing the frontiers of science forward.

Synonyms
2338-31-0
BENZIMIDAZOLE, 4-CHLORO-2-(TRIFLUOROMETHYL)-
BRN 0525680
4-Chloro-2-(trifluoromethyl)benzimidazole
DTXSID50177938
DTXCID10100429
4-Chloro-2-(trifluoromethyl)-1H-benzo[d]imidazole
4-chloro-2-(trifluoromethyl)-1H-benzimidazole
2-(Trifluoromethyl)-4-chloro-1H-benzimidazole
7-Chloro-2-(trifluoromethyl)-1H-benzo[d]imidazole
SCHEMBL9504942
chlorotrifluoromethyl benzimidazole
WUDKQPQAAUQCLT-UHFFFAOYSA-N
MFCD01658394
AKOS005151945
CS-0333524
4-Chloro-2-trifluoromethyl-1H-benzoimidazole