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4-Chloro-3-(1-methylpyrrolidin-2-yl)indole

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Identification
Molecular formula
C13H15ClN2
CAS number
1342700-55-6
IUPAC name
4-chloro-3-(1-methylpyrrolidin-2-yl)-1H-indole
State
State
At room temperature, 4-Chloro-3-(1-methylpyrrolidin-2-yl)-1H-indole is in a solid state with crystalline appearance.
Melting point (Celsius)
132.50
Melting point (Kelvin)
405.60
Boiling point (Celsius)
332.50
Boiling point (Kelvin)
605.70
General information
Molecular weight
244.74g/mol
Molar mass
244.7360g/mol
Density
1.2200g/cm3
Appearence

4-Chloro-3-(1-methylpyrrolidin-2-yl)-1H-indole typically appears as a solid crystalline substance which can have a variety of colors, often ranging from off-white to pale yellow.

Comment on solubility

Solubility of 4-chloro-3-(1-methylpyrrolidin-2-yl)-1H-indole

The solubility of 4-chloro-3-(1-methylpyrrolidin-2-yl)-1H-indole can be influenced by various factors, making it an interesting compound to discuss. Here are some key points regarding its solubility characteristics:

  • Polarity: As a compound featuring both aromatic and aliphatic components, its solubility is likely to be affected by the polarity of the solvent.
  • Hydrogen bonding: The presence of a pyrrolidine group may enable hydrogen bonding with polar solvents, potentially enhancing its solubility in those environments.
  • Solvent compatibility: The solubility in water may be limited due to the hydrophobic nature of the indole moiety, while organic solvents like ethanol or DMSO could provide better solubility results.
  • Temperature effects: Like many organic compounds, increasing temperature may improve solubility, particularly in non-polar solvents.

In conclusion, while 4-chloro-3-(1-methylpyrrolidin-2-yl)-1H-indole may show variable solubility depending on the solvent used, understanding its structural characteristics can provide insights into optimizing its solubility profile for various applications.

Interesting facts

4-Chloro-3-(1-methylpyrrolidin-2-yl)-1H-indole

This intriguing compound, known as 4-chloro-3-(1-methylpyrrolidin-2-yl)-1H-indole, showcases the fascinating intersection of organic chemistry and medicinal applications. Characterized by its structural complexity, it belongs to the indole family, which is notable for its significant role in biological systems and pharmacology.

Key Features

  • Structural Significance: The indole scaffold is a vital motif in numerous natural products and pharmaceuticals. Its ability to mimic neurotransmitters makes it an essential building block in drug discovery.
  • Chlorine Influence: The presence of a chlorine atom in its structure is known to enhance the compound's reactivity and biological activity, frequently influencing its potency and selectivity.
  • Pyrrolidine Linkage: The incorporation of the 1-methylpyrrolidin group suggests potential interactions with neurotransmitter receptors, hinting at its role in central nervous system activities.

Research Potential

Compounds like 4-chloro-3-(1-methylpyrrolidin-2-yl)-1H-indole are often explored for their:

  • Antidepressant Properties: Researchers examine the therapeutic potential of similar compounds in treating mood disorders.
  • Antipsychotic Effects: The molecular structure may align with properties beneficial for managing conditions like schizophrenia.
  • Neuroprotective Applications: Its ability to cross the blood-brain barrier presents a unique opportunity for neuroprotective drug development.

Quote from a Researcher

As one researcher aptly stated, “The key to innovation in drug design often lies in the transformation of known scaffolds, allowing us to develop new therapeutics that could change lives.”

In summary, 4-chloro-3-(1-methylpyrrolidin-2-yl)-1H-indole is not just a chemical structure but a beacon of possibility in medical research and organic synthesis. Its diverse applications and implications for health make it a compelling subject of study for scientists and students alike.

Synonyms
4-chloro-3-(1-methylpyrrolidin-2-yl)-1H-indole
19137-84-9
4-Chloro-3-(1-methyl-2-pyrrolidinyl)-1H-indole
BRN 0524846
4-Chloro-3-(1-methyl-2-pyrrolidinyl)indole
INDOLE, 4-CHLORO-3-(1-METHYL-2-PYRROLIDINYL)-
DTXSID70940747