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4-Chloro-3-nitrobenzamide

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Identification
Molecular formula
C7H5ClN2O3
CAS number
61833-41-2
IUPAC name
4-chloro-3-nitro-benzamide
State
State

4-Chloro-3-nitrobenzamide is typically found in a solid state at room temperature.

Melting point (Celsius)
181.00
Melting point (Kelvin)
454.00
Boiling point (Celsius)
375.50
Boiling point (Kelvin)
648.70
General information
Molecular weight
200.57g/mol
Molar mass
200.5660g/mol
Density
1.5790g/cm3
Appearence

4-Chloro-3-nitrobenzamide is an off-white to yellow crystalline solid. The compound is characterized by its crystalline form which is typical of many benzamide derivatives. It may appear as a powder or small crystals.

Comment on solubility

Solubility of 4-chloro-3-nitro-benzamide

The solubility of 4-chloro-3-nitro-benzamide (C7H6ClN3O2) in various solvents can be an intriguing topic of discussion. This compound exhibits variable solubility characteristics depending on the solvent used. Here are some key points regarding its solubility:

  • Polar Solvents: 4-chloro-3-nitro-benzamide is generally more soluble in polar solvents like water and ethanol due to the presence of the amide functional group, which can engage in hydrogen bonding.
  • Non-Polar Solvents: In contrast, its solubility in non-polar solvents is relatively low. This behavior can be attributed to the compound's polar functional groups that do not interact favorably with non-polar media.
  • Temperature Influence: The solubility may also increase with temperature. As temperature rises, solubility often improves due to increased molecular motion and interactions.

Overall, solubility is a critical aspect of understanding the behavior and applications of 4-chloro-3-nitro-benzamide. To sum up:

  1. High solubility in polar solvents.
  2. Low solubility in non-polar solvents.
  3. Temperature can enhance solubility.

These factors collectively help to outline the compound's behavior in different chemical environments, making it important for further studies and applications.

Interesting facts

Interesting Facts about 4-Chloro-3-Nitro-Benzamide

4-Chloro-3-nitro-benzamide is a fascinating compound that belongs to the class of organic compounds known as aromatic amides. Here are some intriguing insights into its properties and applications:

  • Intermediate in Synthesis: This compound often serves as an important intermediate in the synthesis of various pharmaceutical products and agrochemicals.
  • Influence of Substituents: The presence of both a chloro and a nitro group on the aromatic ring significantly affects its chemical reactivity, making it a prime candidate for electrophilic substitution reactions.
  • Biological Activity: Compounds with similar structures often exhibit biological properties, including antibacterial and anticancer activities, attracting interest in medicinal chemistry.
  • Environmental Considerations: Due to the presence of halogen and nitro groups, careful consideration of its environmental impact and degradation pathways is crucial when synthesizing or utilizing this compound.
  • Chemistry Research: The study of 4-chloro-3-nitro-benzamide encourages students and researchers alike to delve into the world of functional group chemistry, particularly regarding electron-withdrawing and electron-donating effects on aromatic systems.

As a compound rich in potential applications and challenges, 4-chloro-3-nitro-benzamide exemplifies the intricate balance between utility and environmental responsibility in modern chemistry.

Synonyms
4-Chloro-3-nitrobenzamide
BENZAMIDE, 4-CHLORO-3-NITRO-
3-Nitro-4-chlorobenzamide
4-Chlor-3-nitrobenzamid
4-Chlor-3-nitrobenzamid [Czech]
EINECS 240-644-1
NSC 127825
BRN 0645210
DTXSID0066086
4-09-00-01227 (Beilstein Handbook Reference)
DTXCID5035327
240-644-1
16588-06-0
MFCD00017134
A4JS3WES3X
NSC-127825
Benzamide,4-chloro-3-nitro-
NSC127825
UNII-A4JS3WES3X
SCHEMBL6473
3-nitro-4-chloro-benzamide
4-chloro-3-nitro-benzamide
LCZC1531
SCHEMBL1806187
CHEMBL1977211
SBB092661
STL140675
AKOS000200717
FC70253
SB77830
AC-25147
AS-30244
NCI60_000636
ST001805
SY073456
DB-043631
C3176
CS-0062147
NS00025429
EN300-15610
SR-01000042870
SR-01000042870-1
Z33546376