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4-Chloro-3-nitrobenzenesulfonamide

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Identification
Molecular formula
C6H5ClN2O4S
CAS number
6427-23-0
IUPAC name
4-chloro-3-nitro-benzenesulfonamide
State
State
At room temperature, 4-Chloro-3-nitrobenzenesulfonamide is in a solid state, usually forming yellow crystalline structures.
Melting point (Celsius)
183.00
Melting point (Kelvin)
456.15
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.15
General information
Molecular weight
250.64g/mol
Molar mass
250.6400g/mol
Density
1.6000g/cm3
Appearence

4-Chloro-3-nitrobenzenesulfonamide is typically found as a yellow crystalline solid. Its appearance might vary slightly depending on factors like purity and environmental conditions.

Comment on solubility

Solubility of 4-chloro-3-nitro-benzenesulfonamide

The solubility of 4-chloro-3-nitro-benzenesulfonamide in various solvents can significantly affect its applications and effectiveness in chemical processes. Generally, this compound exhibits the following solubility characteristics:

  • Solvent Type: 4-chloro-3-nitro-benzenesulfonamide is known to have low solubility in nonpolar solvents, such as hexane or toluene. This is due to its polar functional groups that do not interact favorably with hydrophobic solvents.
  • Water Solubility: The compound demonstrates limited solubility in water. This is attributed to the presence of the sulfonamide group, which can form hydrogen bonds, albeit not sufficiently strong to increase overall solubility in aqueous solutions.
  • Polar Solvents: Solubility increases in polar organic solvents like dimethyl sulfoxide (DMSO) or methanol, where stronger interactions can occur, aiding in the dissolving process.

It is important to note that the pH of the solution can also influence solubility:

  • Acidic Conditions: Under acidic conditions, the protonation of the sulfonamide group may enhance solubility.
  • Basic Conditions: Conversely, at higher pH levels, deprotonation leads to reduced solubility due to increased ionic character.

To summarize, the solubility of 4-chloro-3-nitro-benzenesulfonamide is:

  1. Low in water
  2. Better in polar solvents
  3. Highly influenced by pH

Understanding these solubility traits is crucial for scientists leveraging this compound in various chemical reactions and formulations.

Interesting facts

Interesting Facts About 4-Chloro-3-nitro-benzenesulfonamide

4-Chloro-3-nitro-benzenesulfonamide is a fascinating compound that plays a significant role in both chemical research and medicinal applications. Here are some intriguing insights into this compound:

  • Antibacterial Properties: This compound has been noted for its potential antibacterial properties, making it an important subject of study in the development of new antibiotics.
  • Functional Groups: The structure contains various functional groups, including a chloro group, a nitro group, and a benzenesulfonamide moiety, which contribute to its unique chemical behavior.
  • Applications in Pharmaceuticals: 4-Chloro-3-nitro-benzenesulfonamide serves as a key intermediate in the synthesis of several pharmaceutical agents, showcasing its utility in drug design and development.
  • Importance in Organic Synthesis: The compound is used in organic synthesis as a building block for more complex molecules, highlighting its versatility for chemists.
  • Research Interests: Scientists are continually exploring the potential effects of this compound, particularly in relation to its toxicity and long-term impact on health and the environment.

In summary, 4-Chloro-3-nitro-benzenesulfonamide is more than just a simple chemical compound. Its diverse functionalities and applications make it a critical area of focus for researchers and a prominent example of how small molecules can have a substantial impact in various scientific fields.

Synonyms
4-CHLORO-3-NITROBENZENESULFONAMIDE
97-09-6
3-Nitro-4-chlorobenzenesulfonamide
Benzenesulfonamide, 4-chloro-3-nitro-
4-chloro-3-nitrobenzene-1-sulfonamide
4-Chloro-3-nitrobenzenesulphonamide
HSDB 2568
UNII-2O1T5ZXF22
2O1T5ZXF22
4-Chloro-3-nitro-benzenesulfonamide
EINECS 202-559-8
MFCD00035783
NSC 512314
NSC-512314
CHEMBL51663
DTXSID8052649
4-CHLORO-3-NITROBENZENESULPHONAMIDE [HSDB]
3-Nitro-4-chlorobenzensulfonyl amine
SCHEMBL1184879
DTXCID9031222
Benzenesulfonamide, 4chloro3nitro
2-nitrochlorobenzene-4-sulfonamide
BDBM50101939
GEO-03915
NSC512314
STL483063
4-chloro-3-nitro-benzene sulfonamide
AKOS000115239
AKOS025293419
CS-W014155
PS-4334
SB17976
4-Chloro-3-nitrobenzene-1-sulphonamide
SY037322
DB-006506
NS00040510
EN300-01188
O11215
SR-01000311153
SR-01000311153-1
Q27255164
Z45415559