Skip to main content

Bixafen

ADVERTISEMENT
Identification
Molecular formula
C17H12ClF3N4O
CAS number
581809-46-3
IUPAC name
4-chloro-5-(methylamino)-2-[3-(trifluoromethyl)phenyl]pyridazin-3-one
State
State

Bixafen is typically a solid at room temperature. It's presented commonly as a technical grade solid or powder in agricultural formulations, being used primarily as a fungicide.

Melting point (Celsius)
131.50
Melting point (Kelvin)
404.65
Boiling point (Celsius)
289.30
Boiling point (Kelvin)
562.45
General information
Molecular weight
403.74g/mol
Molar mass
403.7400g/mol
Density
1.5200g/cm3
Appearence

Bixafen is a solid at room temperature and appears as an off-white to pale beige powder. The precise color and texture can vary depending on its purity and the form it is presented in. It is typically handled in a laboratory setting in powdered form.

Comment on solubility

Solubility Characteristics

The solubility of 4-chloro-5-(methylamino)-2-[3-(trifluoromethyl)phenyl]pyridazin-3-one is influenced by several factors. Here are some key points to consider:

  • Polarity: The presence of functional groups, such as the methylamino and trifluoromethyl moieties, suggests a complex polarity profile that can affect solubility in various solvents.
  • Solvent Compatibility: This compound may exhibit decent solubility in polar solvents like methanol or ethanol due to the availability of hydrogen bonding interactions between the solvent and the amino group.
  • Hydrophobic Interactions: The trifluoromethyl group is hydrophobic, which could limit solubility in water while enhancing solubility in organic solvents.
  • Temperature Dependence: Like many organic compounds, solubility may increase with temperature, making it essential to consider the conditions under which solubility is being evaluated.

In summary, the solubility of 4-chloro-5-(methylamino)-2-[3-(trifluoromethyl)phenyl]pyridazin-3-one is likely to be variable based on environmental conditions such as temperature and the choice of solvent. Understanding these aspects is crucial for effective use in chemical applications.

Interesting facts

Interesting Facts about 4-chloro-5-(methylamino)-2-[3-(trifluoromethyl)phenyl]pyridazin-3-one

This compound, with its intricate molecular structure, possesses several intriguing attributes that astound both chemists and pharmacologists alike.

Unique Chemical Structure

The 4-chloro-5-(methylamino)-2-[3-(trifluoromethyl)phenyl]pyridazin-3-one features a unique pyridazine ring, which is less common compared to other nitrogen-containing heterocycles. The presence of both chloro and trifluoromethyl groups enhances its chemical versatility, making it a fascinating subject of study in medicinal chemistry.

Potential Applications

  • Pharmaceutical Research: This compound has been investigated for its potential role in developing new therapeutic agents, particularly in the treatment of various cancers.
  • Biological Activity: Initial studies suggest that it may exhibit anti-inflammatory and analgesic properties, prompting further research into its mechanisms of action.

Importance of Substituents

The various substituents on this compound play a crucial role in modulating its biological activity. For example:

  • Chloro Group: Often recognized for enhancing lipophilicity, potentially improving the compound's pharmacokinetic properties.
  • Methylamino Group: May influence receptor binding affinity, a key factor in the efficacy of drug candidates.
  • Trifluoromethyl Group: Known for its impact on the electronic environment of the molecule, thus affecting its reactivity and interactions with biological targets.

Quote from a Research Study

As noted in recent journals, "The strategic incorporation of halogenated and functional groups continues to unveil new pathways in drug development, showcasing the promise held by compounds like 4-chloro-5-(methylamino)-2-[3-(trifluoromethyl)phenyl]pyridazin-3-one." This reflects the ongoing excitement within the scientific community regarding the potential implications of this compound.

In summary, 4-chloro-5-(methylamino)-2-[3-(trifluoromethyl)phenyl]pyridazin-3-one is not just a complex chemical entity but also a potential beacon of innovation in drug design and therapeutic applications.

Synonyms
NORFLURAZON
27314-13-2
Norflurazone
Solicam
Zorial
Evital
Telok
SAN 9789
Monometflurazon
Monometflurazone
Evitol
Solicam Rapid
Zorial Rapid 80
Norflurazon technical
Predict
4-Chloro-5-(methylamino)-2-(alpha,alpha,alpha-trifluoro-m-tolyl)-3(2H)-pyridazinone
SAN 9789 H
San 97895
DTXSID8024234
H 9789
4-Chloro-5-(methylamino)-2-[3-(trifluoromethyl)phenyl]-3(2H)-pyridazinone
KES1HB07E4
H 52143
CHEBI:50842
1-(3-Trifluoromethylphenyl)-4-methylamino-5-chloropyridazone
H-9789
H-52,143
DTXCID304234
4-Chloro-5-methylamino-2-(3-trifluoromethylphenyl)pyridazin-3-one
SAN-9789
4-Chloro-5-(methylamino)-2-(3-(trifluoromethyl)phenyl)-3(2H)-pyridazinone
4-Chloro-5-(methylamino)-2-(3-(trifluoromethyl)phenyl)pyridazin-3(2H)-one
4-chloro-5-(methylamino)-2-[3-(trifluoromethyl)phenyl]pyridazin-3(2H)-one
norfluorazon
RefChem:166616
4-chloro-5-(methylamino)-2-(alpha, alpha, alpha-trifluoro-m-tolyl)-3(2H)-pyridazinone
4-chloro-5-(methylamino)-2-(3-(trifluoromethyl)phenyl)-2,3-dihydropyridazin-3-one
4-chloro-5-methylamino-2-(alpha,alpha,alpha-trifluoro-m-tolyl)pyridazin-3(2h)-one
248-397-1
Solicam;Zorial;SAN 9789
4-chloro-5-(methylamino)-2-[3-(trifluoromethyl)phenyl]pyridazin-3-one
3(2H)-Pyridazinone, 4-chloro-5-(methylamino)-2-[3-(trifluoromethyl)phenyl]-
3(2H)-Pyridazinone, 4-chloro-5-(methylamino)-2-(3-(trifluoromethyl)phenyl)-
Caswell No. 195AA
Norflurazone [ISO-French]
Norflurazon [ISO]
CAS-27314-13-2
Norflurazon [ANSI:BSI:ISO]
HSDB 6845
Sandoz 9789
EINECS 248-397-1
UNII-KES1HB07E4
EPA Pesticide Chemical Code 105801
BRN 0757115
Norflurazon (NF)
Norflurazon 10 microg/mL in Acetonitrile
NORFLURAZON [MI]
NORFLURAZON [HSDB]
SCHEMBL54676
5-25-14-00201 (Beilstein Handbook Reference)
orb1299151
CHEMBL1881194
SCHEMBL29776940
1-(3-Trifluoromethylphenyl)-4-methylamino-5-chloro-6-pyridazone
MSK22190
Tox21_202043
Tox21_300701
MFCD00128055
AKOS015903314
FN26452
3(2H)-Pyridazinone, 4-chloro-5-(methylamino)-2-(.alpha.,.alpha.,.alpha.-trifluoro-m-tolyl)-
3(2H)-Pyridazinone, 4-chloro-5-(methylamino)-2-(alpha,alpha,alpha-trifluoro-m-tolyl)-
NCGC00163841-01
NCGC00163841-02
NCGC00163841-03
NCGC00163841-04
NCGC00254609-01
NCGC00259592-01
DA-76262
TS-09782
HY-114849
CS-0064469
NS00004600
C18874
G76853
Norflurazon, PESTANAL(R), analytical standard
AB00081885-01
AE-641/00401064
SR-01000206068
Q1321843
SR-01000206068-1
4-Chloro-5-(methylamino)-2-(.alpha.,.alpha.,.alpha.-trifluoro-m-tolyl)-3(2H)-pyridazinone
4-chloro-5-(methylamino)-2-(alpha,alpha,alpha-trifluoro-m-toluyl)-3-(2H)-pyridazinone
4-Chloro-5-(methylamino)-2-[3-(trifluoromethyl)phenyl]-3(2H)-pyridazinone;1-(3-Trifluoromethylphenyl)-4-methylamino-5-chloro-6-pyrid azone;4-Chloro-5-(methylamino)-2-(a,a,a-trifluoro-m-tolyl)-3(2H)-pyridazinone
4-CHLORO-5-METHYLAMINO-2-(.ALPHA.,.ALPHA.,.ALPHA.-TRIFLUORO-M-TOLYL)PYRIDAZIN-3(2H)-ONE
NRF