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4-Chloro-6-methyl-2-aminopyrimidine

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Identification
Molecular formula
C5H6ClN3
CAS number
1193-22-4
IUPAC name
4-chloro-6-methyl-pyrimidin-2-amine
State
State

The compound is a solid under room temperature conditions, typically shipped and stored in powder or crystalline form. It should remain stable when kept away from excessive heat and light.

Melting point (Celsius)
115.00
Melting point (Kelvin)
388.15
Boiling point (Celsius)
277.80
Boiling point (Kelvin)
550.95
General information
Molecular weight
141.58g/mol
Molar mass
141.5750g/mol
Density
1.2930g/cm3
Appearence

4-Chloro-6-methyl-2-aminopyrimidine typically appears as a white to pale yellow crystalline solid. The compound is relatively stable under normal conditions, and its crystals are generally fine and well-formed.

Comment on solubility

Solubility of 4-chloro-6-methyl-pyrimidin-2-amine

The solubility of 4-chloro-6-methyl-pyrimidin-2-amine in various solvents can provide valuable insights into its chemical behavior and potential applications. Generally, solubility is influenced by several factors, including molecular structure, polarity, and temperature.

Here are some key points regarding the solubility of this compound:

  • Polarity: 4-chloro-6-methyl-pyrimidin-2-amine contains polar functional groups that can interact with polar solvents such as water and methanol. Thus, it is likely to exhibit some degree of solubility in these solvents.
  • Hydrogen Bonding: The presence of amino groups allows for the possibility of hydrogen bonding with water molecules, further enhancing solubility.
  • Solvent Effects: It may have limited solubility in non-polar solvents like hexane due to its more polar character.

In practical terms, quotes from the literature suggest that "the solubility of pyrimidines typically varies significantly based on their substituents, impacting their interactions in different environments.”

Understanding the solubility characteristics of 4-chloro-6-methyl-pyrimidin-2-amine is crucial for its applications in fields such as pharmaceuticals and agrochemicals, guiding researchers in formulation strategies.

Interesting facts

Interesting Facts about 4-chloro-6-methyl-pyrimidin-2-amine

The compound known as 4-chloro-6-methyl-pyrimidin-2-amine is a fascinating example of an organonitrogen compound. Its structure is characterized by a pyrimidine ring, which is a six-membered aromatic ring containing nitrogen atoms. This compound exhibits several noteworthy aspects that make it an interesting subject of study in the field of chemistry:

  • Pharmaceutical Relevance: Compounds like 4-chloro-6-methyl-pyrimidin-2-amine are often found in the realm of pharmaceuticals, where they can serve as intermediates in the synthesis of various therapeutic agents, particularly those used in treating cancer and infectious diseases.
  • Functional Groups: The presence of the chloro and amino functional groups grants this compound unique properties, which can lead to specific reactivity not seen in simpler amines or halides.
  • Potential as a Building Block: It can act as a building block in the synthesis of more complex nitrogen-containing heterocycles, illustrating how foundational compounds can lead to advancements in chemical synthesis and drug discovery.
  • Research Applications: Ongoing research often focuses on how structural modifications of similar compounds can enhance biological activity or reduce toxicity, making them a valuable area of study.

Understanding the properties and potential applications of 4-chloro-6-methyl-pyrimidin-2-amine opens the door to numerous possibilities in medicinal chemistry, making it a compound worthy of further exploration. As a reminder: “Chemical compounds can be simple in constitution but vast in application.”


Synonyms
2-AMINO-4-CHLORO-6-METHYLPYRIMIDINE
5600-21-5
4-chloro-6-methylpyrimidin-2-amine
AM (inhibitor)
2-Pyrimidinamine, 4-chloro-6-methyl-
AM (pesticide)
prepn. AM
4-Chloro-6-methyl-2-pyrimidinamine
4-Chloro-6-methylpyrimidin-2-ylamine
AM (nitrification inhibitor)
Pyrimidine, 2-amino-4-chloro-6-methyl-
NSC 7892
NSC 23661
EINECS 227-018-3
2-Amino-6-chloro-4-methylpyrimidine
BRN 0114297
8ZBB1FM476
CHEBI:58960
AI3-08093
NSC-7892
NSC-23661
UNII-8ZBB1FM476
DTXSID5022229
5-25-10-00178 (Beilstein Handbook Reference)
DTXCID802229
DTXCID00252825
2-Pyrimidinamine, 4-chloro-6-methyl-(9CI)
4-chloro-6-methyl-2-pyridinamine
dtxsid10301691
nptgvvkplwfppx-uhfffaoysa-n
MFCD00006091
MLS000389365
2-amino-4-chloro-6-methyl pyrimidine
SMR000255638
4-chloro-6-methyl-pyrimidin-2-ylamine
cid_21810
SCHEMBL150686
CHEMBL1723906
BDBM47756
NSC7892
HMS1757D09
HMS2536F11
2-amino-4-chloro-6methylpyrimidine
2-Amino-4-methyl-6-chlorpyrimidin
NSC23661
2-Amino-4-methyl-6-chloropyrimidine
4-chloro-6-methyl-2-pyrimidineamine
4-chloro-6-methylpyrimidine-2-amine
STK397556
4-chloro-6-methyl-2-pyrimidinylamine
4-chloro-6-methyl-pyrimidin-2-amine
2-amino-4-chloro-6-methyl-pyrimidine
AKOS000111542
CS-W001984
4-chloranyl-6-methyl-pyrimidin-2-amine
NCGC00246049-01
(4-chloro-6-methyl-pyrimidin-2-yl)amine
AC-15862
AS-11855
SY011380
2-Amino-4-chloro-6-methylpyrimidine, 97%
DB-031853
A1088
NS00015539
EN300-17079
AE-848/06047015
L001028
Q27126362
Z56871954
F0827-0306
DU7