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4-Chloro-6-nitro-2-(trifluoromethyl)-1H-benzimidazole

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Identification
Molecular formula
C8H3ClF3N3O2
CAS number
89466-08-2
IUPAC name
4-chloro-6-nitro-2-(trifluoromethyl)-1H-benzimidazole
State
State

At room temperature, 4-Chloro-6-nitro-2-(trifluoromethyl)-1H-benzimidazole is typically found in a solid state. It is not typically volatile and remains stable under standard laboratory conditions.

Melting point (Celsius)
148.00
Melting point (Kelvin)
421.15
Boiling point (Celsius)
315.00
Boiling point (Kelvin)
588.15
General information
Molecular weight
260.57g/mol
Molar mass
260.5600g/mol
Density
1.6800g/cm3
Appearence

4-Chloro-6-nitro-2-(trifluoromethyl)-1H-benzimidazole is typically a pale yellow solid. It may appear crystalline and is often used in laboratory settings where such chemical properties are observed.

Comment on solubility

Solubility of 4-chloro-6-nitro-2-(trifluoromethyl)-1H-benzimidazole

The solubility of 4-chloro-6-nitro-2-(trifluoromethyl)-1H-benzimidazole can be a critical factor in multiple applications, particularly in pharmaceuticals and agrochemicals. Understanding its solubility behavior is essential for effective formulation and application.

  • Solvent Preferences: This compound may exhibit varying solubility in different solvents. Generally, polar solvents like ethanol and methanol might enhance its solubility due to potential intermolecular interactions. Conversely, non-polar solvents may lead to lower solubility.
  • Temperature Influence: The solubility of many chemical compounds can change with temperature. An increase in temperature often results in enhanced solubility, making it crucial to assess how this benzimidazole behaves under different thermal conditions.
  • pH Effects: Given the presence of nitro and chloro substituents, the solubility of 4-chloro-6-nitro-2-(trifluoromethyl)-1H-benzimidazole may be influenced by the pH of the solution, whereby acidic or basic conditions could alter its ionization state and hence its solubility.
  • Crystallization and Polymorphism: The crystalline structure of this compound can significantly affect its solubility. Different polymorphic forms may exhibit distinct solubility profiles, an aspect that can be vital to consider in product development.

To summarize, the solubility of 4-chloro-6-nitro-2-(trifluoromethyl)-1H-benzimidazole is likely to be influenced by various factors including solvent type, temperature, pH, and molecular structure. As with many compounds, thorough testing and characterization in relevant environments will provide a clearer picture of its solubility behavior.

Interesting facts

Interesting Facts about 4-chloro-6-nitro-2-(trifluoromethyl)-1H-benzimidazole

4-chloro-6-nitro-2-(trifluoromethyl)-1H-benzimidazole is a fascinating compound that showcases the intricate world of synthetic chemistry. This compound belongs to the benzimidazole family, which is renowned for its wide range of biological activities and applications in medicinal chemistry. Here are some compelling aspects of this compound:

  • Biological Significance: Compounds in the benzimidazole class often exhibit various pharmacological properties, including antibacterial, antifungal, and anti-inflammatory activities. This specific compound may provide unique insights into the development of new pharmaceuticals.
  • Halogen Influence: The presence of chlorine and trifluoromethyl groups in its structure can significantly affect the compound's reactivity and potency. Such alterations can enhance lipophilicity and metabolic stability, making it a subject of interest in drug discovery.
  • Synthetic Versatility: The functional groups on this benzimidazole derivative allow for diverse synthetic pathways. Chemists can manipulate these functional groups to create novel compounds with tailored properties.
  • Environmental Considerations: The trifluoromethyl group is often investigated for its environmental impact. Understanding how compounds like this one behave in various conditions can help assess their safety and environmental footprint.
  • Potential Applications: Beyond its pharmacological potential, compounds containing the benzimidazole structure are also explored in fields such as agricultural chemistry, due to their efficacy as fungicides and herbicides.

As we delve deeper into the chemistry of 4-chloro-6-nitro-2-(trifluoromethyl)-1H-benzimidazole, we uncover not just its potential uses but also the rich tapestry of interactions and modifications that define its properties. This compound exemplifies how small changes in molecular structure can lead to significant shifts in functional behavior.

Synonyms
BENZIMIDAZOLE, 4-CHLORO-6-NITRO-2-(TRIFLUOROMETHYL)-
BRN 0962224
4228-91-5
4-Chloro-6-nitro-2-(trifluoromethyl)benzimidazole
DTXSID60195108
DTXCID30117599
SCHEMBL8855468
HNDQGIJHWSTKDW-UHFFFAOYSA-N