4-chloro-N-[2-methyl-1-phenyl-2-(1-piperidyl)propylidene]benzamide

Identification

Molecular formula

C₂₁H₂₅ClN₂O

CAS number

21521-52-2

IUPAC name

4-chloro-N-[2-methyl-1-phenyl-2-(1-piperidyl)propylidene]benzamide

State

The compound is a solid at room temperature. It exists in a stable crystalline form and, due to its aromatic and chlorine substituents, it demonstrates low volatility. Handle with care to avoid dust generation.

Melting point (Celsius)

213.30

Melting point (Kelvin)

486.40

Boiling point (Celsius)

540.70

Boiling point (Kelvin)

813.90

General information

Molecular weight

354.87g/mol

Molar mass

354.8710g/mol

Density

1.2587g/cm³

Appearence

The compound typically appears as a white to off-white crystalline solid. As it is a benzamide derivative, its crystalline form may have a characteristic sheen. It may also exhibit slight hygroscopic properties, meaning it can absorb moisture from the air, and may have a pleasant or faint odor associated with aromatic amides.

Comment on solubility

Solubility of 4-chloro-N-[2-methyl-1-phenyl-2-(1-piperidyl)propylidene]benzamide

The solubility of 4-chloro-N-[2-methyl-1-phenyl-2-(1-piperidyl)propylidene]benzamide is a significant aspect of its behavior in various environments. Understanding its solubility can help in determining its applicability in pharmaceutical formulations and chemical processes. Here are some key points to consider:

Polar vs. Non-Polar Solvents: This compound has characteristics that may make it soluble in organic solvents, yet poorly soluble in polar solvents such as water. Its aromatic structure and chloro substitution generally favor solubility in non-polar environments.
Temperature Dependence: Solubility can often increase with temperature. Testing this compound at elevated temperatures may yield better solubility results.
pH Influence: The solubility behavior can also be affected by the pH of the solvent, due to potential ionization of functional groups that may be present in the compound.
Crystal Structure: The crystalline nature and lattice energy of 4-chloro-N-[2-methyl-1-phenyl-2-(1-piperidyl)propylidene]benzamide can affect how readily it dissolves, especially under various conditions.

In conclusion, while detailed solubility data for this specific compound may vary, factors such as solvent type, temperature, and pH should be systematically studied to fully understand its solubility profile. Assessing solubility is crucial for optimizing formulations and applications.

Interesting facts

Interesting Facts about 4-chloro-N-[2-methyl-1-phenyl-2-(1-piperidyl)propylidene]benzamide

This fascinating compound belongs to the class of organic chemicals called amides, which are derivatives of carboxylic acids. Its unique structure features a piperidine ring, which is known for its various applications in pharmaceuticals. Here are some intriguing aspects of this compound:

Versatile Applications: Compounds similar to 4-chloro-N-[2-methyl-1-phenyl-2-(1-piperidyl)propylidene]benzamide are often explored for their potential as therapeutic agents in treating a variety of ailments, particularly in the field of mental health.
Structure-Activity Relationship: Understanding the relationship between its molecular structure and biological activity is essential. The presence of the chloro group and piperidine can significantly influence its pharmacological properties.
Synthesis: The synthesis of such amides often involves condensation reactions between amines and carboxylic acid derivatives. Organic chemists employ a variety of strategies to fine-tune synthesis, which can lead to the development of new derivatives with improved efficacy.
Research Interest: Due to its complex structure, this compound is an ongoing subject of research. Studies often focus on modifications that could enhance its therapeutic profile or reduce side effects.

In the realm of medicinal chemistry, compounds like 4-chloro-N-[2-methyl-1-phenyl-2-(1-piperidyl)propylidene]benzamide showcase the intricate dance between chemical structure and biological activity. As researchers continue to unravel the mysteries of this compound, it serves as a reminder of the potential that lies within the world of organic chemistry, where every configuration can lead to novel applications and discoveries.