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Chlorthiamide

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Identification
Molecular formula
C9H11ClN2O3S
CAS number
2439-01-2
IUPAC name
4-chloro-N-methyl-3-(methylsulfamoyl)benzamide
State
State

At room temperature, Chlorthiamide is in a solid state.

Melting point (Celsius)
155.00
Melting point (Kelvin)
428.15
Boiling point (Celsius)
506.60
Boiling point (Kelvin)
779.75
General information
Molecular weight
249.72g/mol
Molar mass
249.7190g/mol
Density
1.3900g/cm3
Appearence

This compound typically exists as an off-white to light yellow solid.

Comment on solubility

Solubility of 4-chloro-N-methyl-3-(methylsulfamoyl)benzamide

The solubility of 4-chloro-N-methyl-3-(methylsulfamoyl)benzamide is an important factor in its practical applications, especially in pharmaceuticals and research. Understanding solubility can often be summarized by considering several key aspects:

  • Polarity: The presence of both a chloride group and a methylsulfamoyl moiety contributes to the polarity of the compound, which typically enhances its solubility in polar solvents, particularly water.
  • Hydrogen Bonding: The potential for hydrogen bonding due to the sulfamoyl functional group may also significantly increase the solubility in aqueous environments. This interaction can lead to favorable solvation energies.
  • Solvent Compatibility: It is anticipated that 4-chloro-N-methyl-3-(methylsulfamoyl)benzamide may have excellent solubility in common organic solvents like methanol and ethanol, but limited solubility in non-polar solvents.
  • Temperature Dependence: Like many organic compounds, solubility may be affected by temperature, where higher temperatures can generally lead to increased solubility.

In summary, while the specific solubility data for 4-chloro-N-methyl-3-(methylsulfamoyl)benzamide should be referenced from experimental sources, the physical and chemical properties suggest it is likely to demonstrate good solubility in polar solvents due to its electronic characteristics and functional groups. As always, thorough experimentation is recommended to obtain precise solubility values.

Interesting facts

Interesting Facts about 4-chloro-N-methyl-3-(methylsulfamoyl)benzamide

4-chloro-N-methyl-3-(methylsulfamoyl)benzamide is a fascinating compound in the realm of organic chemistry, particularly in pharmaceuticals and agrochemicals. This compound belongs to the class of sulfonamides, which are known for their remarkable properties and applications.

Applications

  • Pharmaceutical Uses: This compound is often investigated for its potential as a therapeutic agent due to its structural similarity to several biologically active molecules. It is particularly noted for its activity in inhibiting specific enzymes.
  • Agrochemical Potential: Its role in agriculture cannot be overlooked, as compounds like this are studied for their effectiveness in pest control and as herbicides.

Chemical Properties

One of the striking features of 4-chloro-N-methyl-3-(methylsulfamoyl)benzamide is its ability to form strong hydrogen bonds, contributing to its biological activity. The presence of the chlorine atom and sulfonamide functional group enhances its reactivity and solvent properties. As a result, this compound often serves as a lead compound in drug design.

Research Insights

In recent studies, researchers have focused on:

  • Understanding its mechanism of action within biological systems.
  • Exploring its interactions with proteins and other biomolecules.
  • Modifying its structure to improve efficacy and reduce toxicity.

Overall, 4-chloro-N-methyl-3-(methylsulfamoyl)benzamide exemplifies the intricate connections between chemical structure and biological activity, making it an exciting topic of ongoing research in fields such as medicinal chemistry and environmental science. As one researcher stated, "The journey of discovering new pharmacologically active compounds is often paved with seemingly simple structures that reveal complex interactions."

These properties and potentials make 4-chloro-N-methyl-3-(methylsulfamoyl)benzamide a compound of great interest in the scientific community, paving the way for innovative applications that can address both health and agricultural challenges.

Synonyms
Diapamide
Tiamizide
3688-85-5
4-Chloro-N-methyl-3-(methylsulfamoyl)benzamide
Thiamizide
Tiamizid
Vectren
CI-456
Tiamizida
Diapamide [USAN]
Tiamizidum
Tiamizidum [INN-Latin]
Tiamizida [INN-Spanish]
Tiamizide [INN]
D-1593
CN-36337
CN-36,337
C.I. 456
UNII-887WQB35ME
D 1593
Diapamide (USAN)
NSC 178204
NSC-178204
BRN 2138735
887WQB35ME
BENZAMIDE, 4-CHLORO-N-METHYL-3-(METHYLSULFAMOYL)-
TIAMIZIDE [WHO-DD]
4-Chloro-N-methyl-3-((methylamino)sulfonyl)benzamide
Benzamide, 4-chloro-N-methyl-3-((methylamino)sulfonyl)-
DTXSID30190362
Tiamizidum (INN-Latin)
Tiamizida (INN-Spanish)
Benzamide, 4-chloro-N-methyl-3-[(methylamino)sulfonyl]-
4-chloro-N-methyl-3-[(methylamino)sulfonyl]benzamide
DTXCID40112853
SCHEMBL119354
WLN: 1MVR DG CSWM1
CHEMBL2104271
CI 456
NSC178204
AKOS040751551
NS00007666
D03764
Q27269902
Z30271463