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Furosemide

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Identification
Molecular formula
C12H11ClN2O5S
CAS number
54-31-9
IUPAC name
4-chloro-N1-methyl-N1-[(2-methyltetrahydrofuran-2-yl)methyl]benzene-1,3-disulfonamide
State
State

At room temperature, Furosemide is typically found in a solid state, specifically a crystalline powder. It needs to be stored in conditions away from excessive moisture and light.

Melting point (Celsius)
206.50
Melting point (Kelvin)
479.70
Boiling point (Celsius)
450.50
Boiling point (Kelvin)
723.70
General information
Molecular weight
330.74g/mol
Molar mass
330.7420g/mol
Density
1.6673g/cm3
Appearence

Furosemide appears as a white to slightly yellow crystalline powder. It is odorless and tasteless, providing a neutral appearance under standard conditions.

Comment on solubility

Solubility of 4-chloro-N1-methyl-N1-[(2-methyltetrahydrofuran-2-yl)methyl]benzene-1,3-disulfonamide (C12H11ClN2O5S)

The solubility of 4-chloro-N1-methyl-N1-[(2-methyltetrahydrofuran-2-yl)methyl]benzene-1,3-disulfonamide is influenced by several key factors, primarily its molecular structure and the presence of functional groups. Solubility can be described as the extent to which a compound can dissolve in a solvent, typically water or organic solvents.

In the case of this compound, consider the following:

  • Polarity: The presence of sulfonamide groups often leads to an increase in polarity, promoting solubility in polar solvents such as water.
  • Hydrophobic regions: The aromatic benzene rings and hydrophobic hydrocarbons may reduce solubility in highly polar solvents.
  • Solvent interactions: Solubility may also depend on the interactions with solvents; for instance, strong hydrogen bonding between sulfonamide and water can enhance solubility.

It is generally observed that while this compound may exhibit reasonable solubility in polar solvents, it could present challenges in non-polar solvents owing to its hybrid structure. Thus, it is prudent to evaluate the solubility under various conditions:

  1. Test solubility in water to gauge its polar characteristics.
  2. Examine its behavior in organic solvents like ethanol or dimethyl sulfoxide (DMSO).
  3. Consider temperature variations to observe how heat might affect solubility.

Ultimately, the solubility profile of 4-chloro-N1-methyl-N1-[(2-methyltetrahydrofuran-2-yl)methyl]benzene-1,3-disulfonamide could prove to be both intriguing and complex, reflecting the intricate balance between its molecular structure and solvent interactions.

Interesting facts

Interesting Facts about 4-chloro-N1-methyl-N1-[(2-methyltetrahydrofuran-2-yl)methyl]benzene-1,3-disulfonamide

4-chloro-N1-methyl-N1-[(2-methyltetrahydrofuran-2-yl)methyl]benzene-1,3-disulfonamide is a fascinating compound that showcases the complexity of organic chemistry and its applications. Here are some compelling insights:

  • Pharmacological Potential: This compound belongs to the class of sulfonamides, which are well-known for their antibacterial properties. Sulfonamides have been extensively researched for their use in treating a variety of infections, making this compound potentially important in medicinal chemistry.
  • Structure Matters: The unique structural features of this compound, including the presence of a chlorinated benzene ring and a sulfonamide group, contribute to its chemical reactivity and biological activity. The chlorinated groups often enhance the potency of the compound.
  • Reactant Characteristics: As a sulfonamide, this compound can participate in nucleophilic attack reactions, serving as a precursor in the synthesis of other valuable compounds in organic synthesis.
  • Environmental Impact: Understanding the behavior of such synthesized organic compounds is crucial in environmental science, especially regarding their biodegradability and potential ecological impact.

The synthesis and study of 4-chloro-N1-methyl-N1-[(2-methyltetrahydrofuran-2-yl)methyl]benzene-1,3-disulfonamide illustrate the intricate balance between synthetic organic chemistry and its practical applications in pharmaceutical development. As the field progresses, ongoing research may uncover even more valuable uses for this chemical entity.

Synonyms
mefruside
7195-27-9
Mefrusid
Baycaron
Mefrusida
Mefrusal
Mefrusidum
BAY 1500
Mefrusidum [INN-Latin]
Mefrusida [INN-Spanish]
FBA 1500
FDA 1902
BAY-1500
EINECS 230-562-4
X1NS9SNS92
Baycaron (TN)
B 1500
DTXSID0048844
Mefruside [USAN:INN:BAN:JAN]
MEFRUSIDE [INN]
MEFRUSIDE [JAN]
MEFRUSIDE [MI]
MEFRUSIDE [USAN]
1,3-Benzenedisulfonamide, 4-chloro-N1-methyl-N1-((tetrahydro-2-methyl-2-furanyl)methyl)-
MEFRUSIDE [MART.]
MEFRUSIDE [WHO-DD]
4-Chloro-N(sup 1)-methyl-N(sup 1)-(tetrahydro-2-methylfurfuryl)-m-benzenedisulfonamide
N-(4'-Chloro-3'-sulfamoylbenzenesulfonyl)-N-methyl-2-aminomethyl-2-methyltetrahydrofuran
DTXCID7028770
4-Chloro-N-methyl-N-(2-methyltetrahydrofurfuryl)-1,3-benzenesulfonamide
4-chloro-1-N-methyl-1-N-[(2-methyloxolan-2-yl)methyl]benzene-1,3-disulfonamide
1,3-Benzenedisulfonamide, 4-chloro-N(sup 1)-methyl-N(sup 1)-((tetrahydro-2-methyl-2-furanyl)methyl)-
NCGC00183860-01
Mefrusidum (INN-Latin)
Mefrusida (INN-Spanish)
MEFRUSIDE (MART.)
m-Benzenedisulfonamide, 4-chloro-N1-methyl-N1-(tetrahydro-2-methylfurfuryl)-
4-chloro-N1-methyl-N1-((2-methyltetrahydrofuran-2-yl)methyl)benzene-1,3-disulfonamide
m-Benzenedisulfonamide, 4-chloro-N(sup 1)-methyl-N(sup 1)-(tetrahydro-2-methylfurfuryl)-
N-(4-Chloro-3-sulfamoylbenzenesulfonyl)-N-methyl-2-furfurylamine
4-Chloro-N1-methyl-N1-(tetrahydro-2-methylfurfuryl)-m-benzenedisulfonamide
1,3-Benzenedisulfonamide, 4-chloro-N(1-methyl-N1-[(tetrahydro-2-methyl-2-furanyl)methyl]-
1,3-Benzenedisulfonamide, 4-chloro-N(1)-methyl-N(1)-((tetrahydro-2-methyl-2-furanyl)methyl)-
1,3-Benzenedisulfonamide, 4-chloro-N(1)-methyl-N(1)-[(tetrahydro-2-methyl-2-furanyl)methyl]-
UNII-X1NS9SNS92
1,3-Benzenedisulfonamide, 4-chloro-N(1-methyl-N1-((tetrahydro-2-methyl-2-furanyl)methyl)-
4-chloro-N1-methyl-N1-((2-methyloxolan-2-yl)methyl)benzene-1,3-disulfonamide
4-chloro-N1-methyl-N1-[(2-methyloxolan-2-yl)methyl]benzene-1,3-disulfonamide
4-Chloro-N-methyl-N-((2RS)-2-methyltetrahydrofuran-2-ylmethyl)-3-sulfamoylbenzenesulfonamide
4-Chloro-N-methyl-N-[(2RS)-2-methyltetrahydrofuran-2-ylmethyl]-3-sulfamoylbenzenesulfonamide
Oprea1_448045
SCHEMBL49118
Mefruside (JP17/USAN/INN)
CHEMBL2105131
CHEBI:31809
C03BA05
Mefruside 1.0 mg/ml in Methanol
HAA19527
Tox21_113327
AKOS040752989
DB13405
4-chloro-N1-methyl-N1-[(tetrahydro-2-methyl-2-furanyl)methyl]-1,3-benzenedisulfonamide
1ST10578
CAS-7195-27-9
DB-128911
HY-123179
CS-0081664
NS00005886
D01877
Q6807947
230-562-4