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4-chloro-N,N,6-trimethyl-pyrimidin-2-amine

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Identification
Molecular formula
C7H10ClN3
CAS number
66215-27-8
IUPAC name
4-chloro-N,N,6-trimethyl-pyrimidin-2-amine
State
State

At room temperature, 4-chloro-N,N,6-trimethyl-pyrimidin-2-amine is generally found in a solid state.

Melting point (Celsius)
70.00
Melting point (Kelvin)
343.15
Boiling point (Celsius)
255.00
Boiling point (Kelvin)
528.15
General information
Molecular weight
185.64g/mol
Molar mass
185.6400g/mol
Density
1.2100g/cm3
Appearence

4-chloro-N,N,6-trimethyl-pyrimidin-2-amine typically appears as a crystalline solid. The color and crystalline nature can vary depending on the purity and specific conditions of storage.

Comment on solubility

Solubility of 4-chloro-N,N,6-trimethyl-pyrimidin-2-amine

The solubility of 4-chloro-N,N,6-trimethyl-pyrimidin-2-amine in various solvents can vary significantly, influenced by its molecular structure and functional groups. Understanding its solubility characteristics is crucial for applications in organic synthesis and medicinal chemistry.

Key Factors Affecting Solubility:

  • Polarity: The presence of electronegative atoms, such as chlorine, contributes to the overall polarity of the molecule, which affects its solubility in polar solvents.
  • Hydrogen Bonding: Functional groups capable of hydrogen bonding can enhance solubility in protic solvents.
  • Hydrophobic Regions: The trimethyl groups, being hydrophobic, may contribute to lower solubility in polar solvents.

In general, compounds like 4-chloro-N,N,6-trimethyl-pyrimidin-2-amine are expected to demonstrate:

  1. Higher solubility in organic solvents (e.g., DMSO, ethanol).
  2. Limited solubility in water due to hydrophobic characteristics.

As with many organic compounds, it is essential to perform experimental solubility tests to gather precise data, as theoretical predictions may not fully capture real-world behavior. Thus, while 4-chloro-N,N,6-trimethyl-pyrimidin-2-amine may exhibit some solubility in various organic media, its behavior in aqueous solutions could be considerably restricted.

Interesting facts

Interesting Facts about 4-chloro-N,N,6-trimethyl-pyrimidin-2-amine

This compound, commonly referred to in the scientific community, has garnered attention for its unique chemical structure and potential applications. Here are some fascinating facts about 4-chloro-N,N,6-trimethyl-pyrimidin-2-amine:

  • Motif in Medicinal Chemistry: Pyrimidines, including this compound, often serve as *core structures* in pharmaceutical compounds. Their ability to participate in a variety of chemical reactions makes them highly valuable.
  • Versatile Intermediates: This compound may act as an *intermediate* in the synthesis of more complex organic structures, contributing significantly to drug development and other chemical facets.
  • Substituent Importance: The presence of *chloro* and *trimethyl* groups enhances its reactivity. These substitutions can influence both the biological activity and the physicochemical properties of the compound.
  • Research Opportunities: As chemists delve deeper into the properties of this compound, there’s a growing interest in its potential roles in *antimicrobial, antiviral,* and *anticancer* research.
  • Cross-disciplinary Relevance: It's not just chemists who are interested in this compound; it also attracts professionals in fields like *organic chemistry, biochemistry,* and *pharmacology*, highlighting its interdisciplinary significance.

Amidst these attributes, the study of 4-chloro-N,N,6-trimethyl-pyrimidin-2-amine serves as a reminder of the intricate relationships between molecular structure and pharmacological activity. As one scientist aptly put it, “Understanding the nuances of compound interactions will unlock new horizons in medicinal chemistry.”
With the ongoing research, this compound not only represents a small part of the vast chemical universe but also the potential for future discoveries that could impact our lives.

Synonyms
4-Chloro-N,N,6-trimethylpyrimidin-2-amine
5734-62-3
(4-chloro-6-methyl-pyrimidin-2-yl)-dimethyl-amine
66WGL1RRIA
2-N,N-DIMETHYLAMINO-4-CHLORO-6-METHYLPYRIMIDINE
4-Chloro-N,N,6-trimethyl-2-pyrimidinamine
EINECS 227-243-7
UNII-66WGL1RRIA
2-Pyrimidinamine, 4-chloro-N,N,6-trimethyl-
MFCD08361624
(4-Chloro-6-methylpyrimidin-2-yl)dimethylamine
SCHEMBL1586905
CHEMBL4086185
DTXSID50205947
AKOS010518885
SB56348
BS-38346
4-chloro-2-dimethylamino-6-methylpyrimidine
DB-117950
NS00033694
F82294
EN300-1290853
Q27264028
F9994-8380
PYRIMIDINE, 4-CHLORO-2-(DIMETHYLAMINO)-6-METHYL-