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4-Chloroacridine

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Identification
Molecular formula
C13H9ClN2
CAS number
86-37-3
IUPAC name
4-chloroacridin-9-amine
State
State
4-Chloroacridine is usually found in a solid state under room temperature conditions. Its solid form is crystalline and allows for easier handling and storage.
Melting point (Celsius)
223.00
Melting point (Kelvin)
496.15
Boiling point (Celsius)
341.00
Boiling point (Kelvin)
614.15
General information
Molecular weight
214.68g/mol
Molar mass
214.6660g/mol
Density
1.3100g/cm3
Appearence

4-Chloroacridine appears as a crystalline solid that is typically pale yellow in color. Its crystalline form suggests a structured, organized appearance at the microscopic level.

Comment on solubility

Solubility of 4-chloroacridin-9-amine

4-chloroacridin-9-amine, a derivative of acridine, exhibits interesting solubility characteristics that are important for its potential applications in various fields.

Generally, the solubility of 4-chloroacridin-9-amine is affected by several factors:

  • Polarity: The presence of the chlorine atom and the amino group can influence the polarity of the molecule, affecting its solubility in different solvents.
  • Solvent Type: This compound is likely to be more soluble in polar organic solvents compared to non-polar solvents. Solvents such as dimethyl sulfoxide (DMSO) or methanol may enhance its solubility.
  • Hydrogen Bonding: The amino group can participate in hydrogen bonding, which may further increase solubility in polar solvents.
  • Environmental pH: The solubility of 4-chloroacridin-9-amine may vary with pH due to the protonation of the amino group, leading to changes in solubility behavior.

In summary, understanding the solubility of 4-chloroacridin-9-amine is crucial for its application in research and industry, particularly in the fields of pharmaceuticals and materials science. Insight into its solubility dynamics can optimize formulations and lead to more effective utilization of this compound.

Interesting facts

Interesting Facts about 4-Chloroacridin-9-amine

4-Chloroacridin-9-amine is a fascinating chemical compound that belongs to the acridine family, known for its diverse applications in the field of medicinal chemistry. This aromatic amine has piqued the interest of researchers due to its potential as a candidate in various therapeutic areas.

Key Characteristics and Applications

  • Structure and Reactivity: The compound features a chlorinated aromatic system, which significantly influences its reactivity and interaction with biological targets.
  • Antimicrobial Properties: Researchers have explored its potential antimicrobial effects, making it a subject of interest in the development of new antibacterial and antifungal agents.
  • Anticancer Research: Its structural components have been investigated for their ability to inhibit cancer cell proliferation, particularly in certain types of tumors.
  • Research Tool: 4-Chloroacridin-9-amine often serves as a valuable building block in organic synthesis, aiding in the creation of more complex molecules.

One of the compelling aspects of 4-chloroacridin-9-amine is its contribution to the understanding of drug design. As noted by chemists, "the modifications in the acridine nucleus can lead to enhanced pharmacological profiles." This underscores the significance of structural variations in developing new therapeutic agents.

Safety and Handling

Given its chemical nature, it is essential to handle 4-chloroacridin-9-amine with care. Protective measures should be in place to avoid exposure, ensuring safe and responsible use in laboratory settings.

In summary, 4-chloroacridin-9-amine exemplifies the intersection of organic chemistry and pharmacology, showcasing how structural insights can drive innovation in therapeutic development.

Synonyms
ACRIDINE, 9-AMINO-4-CHLORO-
BRN 0172549
23250-40-0
5-Amino-1-chloroacridine (European)
DTXSID00177822
5-22-11-00039 (Beilstein Handbook Reference)
RefChem:317146
DTXCID60100313
CHEMBL148785
SCHEMBL11051320