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4-Chloroaniline

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Identification
Molecular formula
C6H6ClN
CAS number
106-47-8
IUPAC name
4-chloroaniline
State
State
At room temperature, 4-chloroaniline is typically found in a solid state. It remains stable under normal conditions but requires careful handling due to its toxic nature.
Melting point (Celsius)
69.60
Melting point (Kelvin)
342.75
Boiling point (Celsius)
232.20
Boiling point (Kelvin)
505.35
General information
Molecular weight
127.57g/mol
Molar mass
127.5680g/mol
Density
1.1361g/cm3
Appearence

4-Chloroaniline is characterized by its off-white to pale yellow crystalline solid form. It often appears as a powder or crystalline solid that darkens upon prolonged exposure to air and light due to oxidation processes.

Comment on solubility

Solubility of 4-chloroaniline

4-chloroaniline, with the chemical formula C6H6ClN, exhibits interesting solubility properties that are influenced by its molecular structure. Primarily, its solubility can be categorized based on the following observations:

  • Polar Nature: The presence of the amino group (-NH2) contributes to its polar character, enhancing its solubility in polar solvents.
  • Organic Solvents: 4-chloroaniline is generally soluble in organic solvents like ethanol, methanol, and acetone, making it viable for use in various organic reactions.
  • Water Solubility: While 4-chloroaniline has limited solubility in water, it is more soluble at higher temperatures. In cold water, it may precipitate due to reduced solvation.

To summarize, the solubility of 4-chloroaniline can be described as moderate in polar solvents and low in water, with temperature playing a significant role in its solubility profile. This characteristic makes it important for its applications in chemical synthesis and other industrial processes.

Interesting facts

Interesting Facts about 4-Chloroaniline

4-Chloroaniline, also known by its IUPAC name 4-chloroaniline, is an important organic compound that finds its applications in various fields, particularly in the synthesis of dyes and pharmaceuticals. Here are some fascinating insights about this compound:

  • Key Intermediate: 4-Chloroaniline serves as a vital intermediate in the production of numerous dyes, providing color and stability to textiles and other materials.
  • Pharmaceutical Relevance: This compound is used in the synthesis of several pharmaceutical agents, showcasing its versatility in medicinal chemistry.
  • Research and Development: It has been a subject of various studies for its potential therapeutic effects, making it an interesting molecule for drug development.
  • Environmental Considerations: Being a chlorinated compound, it has raised discussions regarding environmental safety, prompting research into safer alternatives and the implications of its use in industrial processes.
  • Safety Precautions: 4-Chloroaniline is known to be toxic, and therefore, it is vital for researchers and workers to use proper protective equipment when handling this compound.
  • Analytical Techniques: Its presence in various mixtures can be monitored using advanced analytical techniques such as gas chromatography and high-performance liquid chromatography, illustrating its significance in analytical chemistry.

In summary, 4-chloroaniline is not just a simple chemical; it is a compound with a rich history and substantial industrial relevance, making it a noteworthy topic of study in both chemistry and environmental science.

Synonyms
4-CHLOROANILINE
106-47-8
p-Chloroaniline
4-Chlorobenzenamine
Benzenamine, 4-chloro-
para-Chloroaniline
p-Chloraniline
4-Chlorophenylamine
p-Chlorophenylamine
1-Amino-4-chlorobenzene
4-Aminochlorobenzene
Aniline, 4-chloro-
p-Aminochlorobenzene
Aniline, p-chloro-
4-Amino-1-chlorobenzene
4-Chloro-1-aminobenzene
4-Chloro-phenylamine
4-Chloranilin
p-CA
4-Chlorobenzamine
Benzeneamine, 4-chloro
4-Chlorobenzeneamine
RCRA waste number P024
Caswell No. 182
4-Chloranilin [Czech]
4-chloro aniline
NCI-C02039
CCRIS 131
NSC 36941
CHEBI:20331
4-CHLORO-ANILINE
HSDB 2047
EINECS 203-401-0
EPA Pesticide Chemical Code 017203
UNII-Z553SGH315
DTXSID9020295
AI3-14908
Z553SGH315
MFCD00007835
NSC-36941
P-CHLOROANILINE [MI]
DTXCID50295
4-CHLOROANILINE [HSDB]
SULOFENUR METABOLITE VIII
P-CHLOROANILINE [USP-RS]
PARA-CHLOROANILINE [IARC]
EC 203-401-0
NCGC00091468-02
4-CHLORANILIN (CZECH)
PROGUANIL HYDROCHLORIDE IMPURITY B [EP IMPURITY]
P-CHLOROANILINE (USP-RS)
PARA-CHLOROANILINE (IARC)
CHLORHEXIDINE DIHYDROCHLORIDE IMPURITY P [EP IMPURITY]
4-?Chloroaniline(4-Chlorophenylamine)
Chloroaniline, p-
RCRA waste no. P024
PROGUANIL HYDROCHLORIDE IMPURITY B (EP IMPURITY)
pChloraniline
pChloroaniline
4chloroaniline
CHLORHEXIDINE DIHYDROCHLORIDE IMPURITY P (EP IMPURITY)
4-chioroaniline
4Chloranilin
monochloroaniline
parachloroaniline
4-chloraniline
4Chlorobenzamine
para-choroaniline
4-Choraniline
p-chloro-aniline
Aniline, pchloro
pChlorophenylamine
para-chioroaniline
4- chloroaniline
4-chlorobenazmine
4Chlorobenzenamine
4Chlorophenylamine
pAminochlorobenzene
Aniline, 4chloro
p-chlorobenzenamine
4Aminochlorobenzene
4-chloroaminobenzene
1Amino4chlorobenzene
4Amino1chlorobenzene
4Chloro1aminobenzene
UN2018
Benzenamine, 4chloro
Benzeneamine, 4chloro
(4-chlorophenyl)amine
4-Chloro-phenyl amine
4-Chloro-phenyl-amine
Chloroaminobenzene, p-
(4-chlorophenyl)-amine
4-Chloroaniline, 98%
WLN: ZR DG
SCHEMBL27544
MLS001065589
BIDD:ER0279
BIDD:GT0259
CHEMBL15888
Aniline, 4-chloro-4-chloranilin
NSC36941
4-Chloroaniline, analytical standard
Tox21_400030
4-Chloroaniline(4-Chlorophenylamine)
BDBM50235880
STK301711
AKOS000119173
FC20361
PS-6272
RP10019
4-?Chloroaniline (4-Chlorophenylamine)
USEPA/OPP Pesticide Code: 017203
NCGC00091468-01
NCGC00091468-03
CAS-106-47-8
SMR000568489
NS00010861
4-Chloroaniline, technical, >=97.0% (GC)
EN300-19099
4-Chloroaniline 100 microg/mL in Acetonitrile
4-Chloroaniline, purified by sublimation, >=99%
Q413515
4-Chloroaniline, PESTANAL(R), analytical standard
F2190-0430
Z104472774
4-Chloroaniline, European Pharmacopoeia (EP) Reference Standard
p-Aminochlorobenzene;p-Chloroaniline;4-Chloro-1-aminobenzene
1,4-aminochlorobenzene;4-amino-1-chlorobenzene;4-aminochlorobenzene
p-Chloroaniline, United States Pharmacopeia (USP) Reference Standard
p-Chloroaniline, Pharmaceutical Secondary Standard; Certified Reference Material
203-401-0