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4-Chlorobenzamide

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Identification
Molecular formula
C7H6ClNO
CAS number
7391-98-0
IUPAC name
4-chlorobenzamide
State
State

At room temperature, 4-chlorobenzamide is a solid. It is stable and maintains its form under typical laboratory conditions.

Melting point (Celsius)
166.00
Melting point (Kelvin)
439.15
Boiling point (Celsius)
328.60
Boiling point (Kelvin)
601.80
General information
Molecular weight
155.58g/mol
Molar mass
155.5780g/mol
Density
1.3810g/cm3
Appearence

4-Chlorobenzamide appears as a white to off-white crystalline solid. It is often found in powder form and is known for its stability under standard conditions. The crystals can reflect light, giving them a slightly shiny appearance.

Comment on solubility

Solubility of 4-Chlorobenzamide

4-Chlorobenzamide, with the chemical formula C7H6ClN1O1, exhibits unique solubility characteristics that are essential for various applications in chemistry and pharmaceuticals. Understanding its solubility is crucial for formulation and reaction processes.

Solubility Characteristics

When discussing the solubility of 4-chlorobenzamide, several key points emerge:

  • Polar vs Nonpolar Solvents: 4-Chlorobenzamide is moderately polar due to the presence of both the amide functional group and the electronegative chlorine atom.
  • Solubility in Water: As a result of its polar characteristics, 4-chlorobenzamide has limited solubility in water, making it more compatible with organic solvents.
  • Organic Solvents: It is generally soluble in common organic solvents such as ethanol, acetone, and chloroform, which can enhance its use in various organic synthesis.

To summarize, the solubility of 4-chlorobenzamide can be described as:

  1. Low solubility in water.
  2. Good solubility in organic solvents.

This solubility profile is critical for researchers as it influences the behavior of the compound in different chemical environments and formulations. As noted in various studies, an understanding of solubility can often lead to optimized reactions and better product development strategies.

In conclusion, the unique solubility properties of 4-chlorobenzamide highlight its versatility in both academic research and industrial applications.

Interesting facts

Interesting Facts about 4-Chlorobenzamide

4-Chlorobenzamide is an intriguing compound within the realm of organic chemistry. Its structure consists of a benzene ring substituted with a chlorine atom and an amide functional group, showcasing the fascinating interplay between aromatic and carbonyl chemistry. Here are some key points to consider:

  • Pharmaceutical Significance: This compound serves as a building block for various pharmaceuticals. Its derivatives are studied for their potential as therapeutic agents.
  • Chlorine's Role: The presence of the chlorine atom enhances the compound's reactivity and bioactivity, influencing how it interacts with biological systems.
  • Research Applications: Scientists frequently investigate 4-chlorobenzamide for its role in drug synthesis, particularly in developing anti-inflammatory and analgesic medications.
  • Environmental Considerations: As with many halogenated compounds, there are discussions around its environmental impact, including its persistence in nature and potential toxicity.
  • Analytical Techniques: 4-Chlorobenzamide can be analyzed using techniques such as HPLC (High-Performance Liquid Chromatography) and NMR (Nuclear Magnetic Resonance), providing insights into its structure and behavior.

In summary, 4-chlorobenzamide is more than just a simple compound; it's a significant contributor to both academic research and real-world applications, making it a remarkable topic of study for chemists and students alike.

Synonyms
4-CHLOROBENZAMIDE
619-56-7
Benzamide, 4-chloro-
p-Chlorobenzamide
Benzamide, p-chloro-
p-Chlorobenzoic acid amide
EINECS 210-601-1
UNII-260CV6K0MR
BRN 0774622
260CV6K0MR
AI3-09668
NSC-74687
NSC-406894
DTXSID50210930
4-09-00-00985 (Beilstein Handbook Reference)
NSC 74687
NSC 406894
DTXCID80133421
Benzamide, p-chloro-(6CI,7CI,8CI)
210-601-1
blnvisnjtirahf-uhfffaoysa-n
4-Chloro-benzamide
1219794-65-6
4-ChlorobenzaMide--d4
MFCD00007993
CHEMBL121999
NSC74687
4-chlorobenzenecarboxamide
4-Chlorobenzamide, 98%
SCHEMBL77931
SCHEMBL8269185
BDBM50106192
NSC406894
STL283912
AKOS000266483
CS-W019519
FC33947
SB75806
AC-10270
SY048513
DB-013433
NS00034865
Q27254022
F3147-3719