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Vorinostat

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Identification
Molecular formula
C17H19ClNO3
CAS number
149647-78-9
IUPAC name
(4-chlorophenyl)-[4-[(dimethylamino)methyl]-5-hydroxy-benzofuran-3-yl]methanone
State
State
At room temperature, Vorinostat is typically a solid. It is handled as a dry powder in laboratory and pharmaceutical settings.
Melting point (Celsius)
141.00
Melting point (Kelvin)
414.15
Boiling point (Celsius)
399.80
Boiling point (Kelvin)
672.95
General information
Molecular weight
264.75g/mol
Molar mass
264.7400g/mol
Density
1.3210g/cm3
Appearence

Vorinostat appears as an off-white to white crystalline powder. It is relatively stable and typically exists as a solid in its pure form.

Comment on solubility

Solubility of (4-chlorophenyl)-[4-[(dimethylamino)methyl]-5-hydroxy-benzofuran-3-yl]methanone

The solubility of the compound (4-chlorophenyl)-[4-[(dimethylamino)methyl]-5-hydroxy-benzofuran-3-yl]methanone can be influenced by various factors including pH, temperature, and the presence of solvents.

In general, the solubility characteristics of such complex organic molecules can be summarized as follows:

  • Polarity: The distribution of polar and non-polar functional groups plays a significant role. The presence of the dimethylamino group may enhance solubility in polar solvents, while the chlorophenyl group may introduce hydrophobic properties.
  • Solvent Interaction: If the compound is tested in various solvents, it is often found soluble in alcohols and dimethyl sulfoxide (DMSO), while showing limited solubility in non-polar solvents.
  • pH Sensitivity: The solubility might also vary significantly with pH due to the potential ionization of the hydroxy group, under acidic or basic conditions.

Overall, efficient solubility assessment requires careful evaluation under defined conditions. As a rule of thumb, the combination of both polar and non-polar elements in the structure complicates the prediction of solubility without empirical data. Understanding these factors can aid in the development and application of the compound in various chemical processes or pharmaceuticals.

Interesting facts

Interesting Facts about (4-chlorophenyl)-[4-[(dimethylamino)methyl]-5-hydroxy-benzofuran-3-yl]methanone

The compound known as (4-chlorophenyl)-[4-[(dimethylamino)methyl]-5-hydroxy-benzofuran-3-yl]methanone is a fascinating example of organic chemistry that showcases both sophisticated molecular structure and potential applications in various fields.

Structural Features

Some of the notable attributes of this compound include:

  • Multiple Ring Systems: The presence of a benzofuran ring adds to the compound's complexity and could influence its reactivity and interactions with biological systems.
  • Dimethylamino Group: This functional group is known for its ability to enhance solubility in organic solvents and may contribute to the compound's pharmacological properties.
  • Chlorine Substitution: The 4-chloro substitution on the phenyl group is significant as halogens often affect the electronic properties, modifying how the molecule interacts with other substances.

Potential Applications

This compound could have intriguing applications, including:

  • Pharmaceutical Development: Given its complex structure, it may play a role in drug development, particularly in designing new therapeutic agents.
  • Research in Organic Synthesis: Chemists may find this compound useful as a building block for synthesizing more complex molecules.
  • Chemical Probes: It might be utilized as a probe in biochemical studies, aiding in understanding various biological interactions.

Significance in Chemistry

In the broader scope of chemistry:

  • Interdisciplinary Interest: The compound appeals to multiple disciplines, including medicinal chemistry, organic synthesis, and analytical chemistry.
  • Inspiration for Future Research: The unique functional groups and structural characteristics could inspire new hypotheses regarding efficacy and functionality in various applications.

In summary, (4-chlorophenyl)-[4-[(dimethylamino)methyl]-5-hydroxy-benzofuran-3-yl]methanone exemplifies the complexity and versatility of modern organic compounds. Its potential impacts in medicinal chemistry and research make it a compound of interest worth exploring further.

Synonyms
(4-chlorophenyl){4-[(dimethylamino)methyl]-5-hydroxy-1-benzofuran-3-yl}methanone
Oprea1_197039
STK180711
AKOS000507250
ST002294
4-[(dimethylamino)methyl]-5-hydroxybenzo[b]furan-3-yl 4-chlorophenyl ketone